TY - JOUR
T1 - Outcome of peripheral T-cell lymphoma in first complete remission
T2 - a Danish-Swedish population-based study
AU - Cederleuf, Henrik
AU - Hjort Jakobsen, Lasse
AU - Ellin, Fredrik
AU - de Nully Brown, Peter
AU - Stauffer Larsen, Thomas
AU - Bøgsted, Martin
AU - Relander, Thomas
AU - Jerkeman, Mats
AU - El-Galaly, Tarec Christoffer
PY - 2017/12
Y1 - 2017/12
N2 - In the present study, we investigate the outcome of 109 Danish and 123 Swedish patients with nodal PTCL in first complete remission (CR), and examine the impact of imaging-based follow-up (FU) strategies. The patients were selected by the following criteria: (a) newly diagnosed nodal PTCL from 2007 to 2012, (b) age ≥18 years, and (c) CR after CHOP or CHOEP therapy. FU guidelines in Sweden included symptom assessment, clinical examinations and blood tests at 3–4-month intervals for 2 years. FU strategies in Denmark was similar but included routine imaging, usually every 6 months for 2 years. Patients had fully comparable characteristics. Overall survival (OS) estimates for patients in CR were similar for all patients (p =.6) and in PTCL subtypes. In multivariate analysis, country of follow-up had no impact on OS. However, despite continuous CR for ≥2 years, the OS of PTCL remained inferior to a matched general population.
AB - In the present study, we investigate the outcome of 109 Danish and 123 Swedish patients with nodal PTCL in first complete remission (CR), and examine the impact of imaging-based follow-up (FU) strategies. The patients were selected by the following criteria: (a) newly diagnosed nodal PTCL from 2007 to 2012, (b) age ≥18 years, and (c) CR after CHOP or CHOEP therapy. FU guidelines in Sweden included symptom assessment, clinical examinations and blood tests at 3–4-month intervals for 2 years. FU strategies in Denmark was similar but included routine imaging, usually every 6 months for 2 years. Patients had fully comparable characteristics. Overall survival (OS) estimates for patients in CR were similar for all patients (p =.6) and in PTCL subtypes. In multivariate analysis, country of follow-up had no impact on OS. However, despite continuous CR for ≥2 years, the OS of PTCL remained inferior to a matched general population.
KW - Peripheral T-cell lymphoma
KW - population based
KW - routine imaging
U2 - 10.1080/10428194.2017.1300888
DO - 10.1080/10428194.2017.1300888
M3 - Journal article
C2 - 28317459
AN - SCOPUS:85015649605
SN - 1042-8194
VL - 58
SP - 2815
EP - 2823
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 12
ER -