Origins of the many NPY-family receptors in mammals

D Larhammar; A Wraith; M M Berglund; S K Holmberg; I Lundell

Origins of the many NPY-family receptors in mammals

D Larhammar, A Wraith, M M Berglund, S K Holmberg, I Lundell

Functional Genomics

92 Citations (Scopus)

Abstract

The NPY system has a multitude of effects and is particularly well known for its role in appetite regulation. We have found that the five presently known receptors in mammals arose very early in vertebrate evolution before the appearance of jawed vertebrates 400 million years ago. The genes Y(1), Y(2) and Y(5) arose by local duplications and are still present on the same chromosome in human and pig. Duplications of this chromosome led to the Y(1)-like genes Y(4) and y(6). We find evidence for two occasions where receptor subtypes probably arose before peptide genes were duplicated. These observations pertain to the discussion whether ligands or receptors tend to appear first in evolution. The roles of Y(1) and Y(5) in feeding may differ between species demonstrating the importance of performing functional studies in additional mammals to mouse and rat.

Original language	English
Journal	Peptides
Volume	22
Issue number	3
Pages (from-to)	295-307
Number of pages	12
ISSN	0196-9781
Publication status	Published - 2001

Cite this

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title = "Origins of the many NPY-family receptors in mammals",

abstract = "The NPY system has a multitude of effects and is particularly well known for its role in appetite regulation. We have found that the five presently known receptors in mammals arose very early in vertebrate evolution before the appearance of jawed vertebrates 400 million years ago. The genes Y(1), Y(2) and Y(5) arose by local duplications and are still present on the same chromosome in human and pig. Duplications of this chromosome led to the Y(1)-like genes Y(4) and y(6). We find evidence for two occasions where receptor subtypes probably arose before peptide genes were duplicated. These observations pertain to the discussion whether ligands or receptors tend to appear first in evolution. The roles of Y(1) and Y(5) in feeding may differ between species demonstrating the importance of performing functional studies in additional mammals to mouse and rat.",

author = "D Larhammar and A Wraith and Berglund, {M M} and Holmberg, {S K} and I Lundell",

note = "Keywords: Amino Acid Sequence; Amino Acids; Animals; Chromosome Mapping; Databases, Factual; Evolution, Molecular; Gene Duplication; Humans; Ligands; Mice; Models, Genetic; Molecular Sequence Data; Multigene Family; Neuropeptide Y; Phylogeny; Rats; Receptors, Neuropeptide Y; Sequence Homology, Amino Acid; Swine",

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T1 - Origins of the many NPY-family receptors in mammals

AU - Larhammar, D

AU - Wraith, A

AU - Berglund, M M

AU - Holmberg, S K

AU - Lundell, I

N1 - Keywords: Amino Acid Sequence; Amino Acids; Animals; Chromosome Mapping; Databases, Factual; Evolution, Molecular; Gene Duplication; Humans; Ligands; Mice; Models, Genetic; Molecular Sequence Data; Multigene Family; Neuropeptide Y; Phylogeny; Rats; Receptors, Neuropeptide Y; Sequence Homology, Amino Acid; Swine

PY - 2001

Y1 - 2001

N2 - The NPY system has a multitude of effects and is particularly well known for its role in appetite regulation. We have found that the five presently known receptors in mammals arose very early in vertebrate evolution before the appearance of jawed vertebrates 400 million years ago. The genes Y(1), Y(2) and Y(5) arose by local duplications and are still present on the same chromosome in human and pig. Duplications of this chromosome led to the Y(1)-like genes Y(4) and y(6). We find evidence for two occasions where receptor subtypes probably arose before peptide genes were duplicated. These observations pertain to the discussion whether ligands or receptors tend to appear first in evolution. The roles of Y(1) and Y(5) in feeding may differ between species demonstrating the importance of performing functional studies in additional mammals to mouse and rat.

AB - The NPY system has a multitude of effects and is particularly well known for its role in appetite regulation. We have found that the five presently known receptors in mammals arose very early in vertebrate evolution before the appearance of jawed vertebrates 400 million years ago. The genes Y(1), Y(2) and Y(5) arose by local duplications and are still present on the same chromosome in human and pig. Duplications of this chromosome led to the Y(1)-like genes Y(4) and y(6). We find evidence for two occasions where receptor subtypes probably arose before peptide genes were duplicated. These observations pertain to the discussion whether ligands or receptors tend to appear first in evolution. The roles of Y(1) and Y(5) in feeding may differ between species demonstrating the importance of performing functional studies in additional mammals to mouse and rat.

M3 - Journal article

C2 - 11287083

SN - 0196-9781

VL - 22

SP - 295

EP - 307

JO - Peptides

JF - Peptides

IS - 3

ER -

Origins of the many NPY-family receptors in mammals

Abstract

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