Organomegaly in Mali before and after praziquantel treatment. A possible association with Schistosoma haematobium

Chalotte Willemann Stecher; Henry Madsen; Shona Wilson; Moussa Sacko; Christian Wejse; Adama D. Keita; Aly Landouré; Mamadou S. Traoré; Per Kallestrup; Eskild Petersen; Birgitte Vennervald

doi:10.1016/j.heliyon.2017.e00440

Organomegaly in Mali before and after praziquantel treatment. A possible association with Schistosoma haematobium

Chalotte Willemann Stecher^*, Henry Madsen, Shona Wilson, Moussa Sacko, Christian Wejse, Adama D. Keita, Aly Landouré, Mamadou S. Traoré, Per Kallestrup, Eskild Petersen, Birgitte Vennervald

^*Corresponding author for this work

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Abstract

Continuous exposure to schistosome-infested water results in acute and chronic morbidity in all ages. We analysed occurence of organomegaly via ultrasonography and investigated a possible additive effect of dual-dose drug administration in 401 Schistosoma haematobium infected individuals from a highly endemic area in Mali. Mean intensity of infection at baseline (22.0 eggs per 10 ml) was reduced to 0.22 eggs per 10 ml 9 weeks after treatment (both treatments combined). Odds of persistent infection among those given dual-dose treatment was 41% of that in people given single dose (b = 0.41; p = 0.05; 95% CI 0.17–1.00), but after two years, 70.7% of the 157 participants, who completed the survey, were re-infected with no significant difference in prevalence and intensity of infection between treatment groups. Resolution of organomegaly occurred in all age groups after treatment. A novel association between Schistosoma haematobium infection and moderate portal vein enlargement was found in 35% (n: 55). Severe portal vein diameter enlargement was found in 3.2%. After two years, moderate hepatomegaly was present in 50.6%, moderate splenomegaly in 45.6% and moderate portal vein diameter enlargement in 19%. A subsequent dose of PZQ did not provide any additional long-term advantages.

Original language	English
Article number	e00440
Journal	Heliyon
Volume	3
Issue number	11
Number of pages	20
ISSN	2405-8440
DOIs	https://doi.org/10.1016/j.heliyon.2017.e00440
Publication status	Published - Nov 2017

Keywords

Infectious disease

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Organomegaly in Mali before and after praziquantel treatment. A possible association with Schistosoma haematobiumFinal published version, 259 KBLicence: CC BY

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@article{df55842cdca84c22ae3b823e3168aa9a,

title = "Organomegaly in Mali before and after praziquantel treatment. A possible association with Schistosoma haematobium",

abstract = "Continuous exposure to schistosome-infested water results in acute and chronic morbidity in all ages. We analysed occurence of organomegaly via ultrasonography and investigated a possible additive effect of dual-dose drug administration in 401 Schistosoma haematobium infected individuals from a highly endemic area in Mali. Mean intensity of infection at baseline (22.0 eggs per 10 ml) was reduced to 0.22 eggs per 10 ml 9 weeks after treatment (both treatments combined). Odds of persistent infection among those given dual-dose treatment was 41% of that in people given single dose (b = 0.41; p = 0.05; 95% CI 0.17–1.00), but after two years, 70.7% of the 157 participants, who completed the survey, were re-infected with no significant difference in prevalence and intensity of infection between treatment groups. Resolution of organomegaly occurred in all age groups after treatment. A novel association between Schistosoma haematobium infection and moderate portal vein enlargement was found in 35% (n: 55). Severe portal vein diameter enlargement was found in 3.2%. After two years, moderate hepatomegaly was present in 50.6%, moderate splenomegaly in 45.6% and moderate portal vein diameter enlargement in 19%. A subsequent dose of PZQ did not provide any additional long-term advantages.",

keywords = "Infectious disease",

author = "Stecher, {Chalotte Willemann} and Henry Madsen and Shona Wilson and Moussa Sacko and Christian Wejse and Keita, {Adama D.} and Aly Landour{\'e} and Traor{\'e}, {Mamadou S.} and Per Kallestrup and Eskild Petersen and Birgitte Vennervald",

year = "2017",

month = nov,

doi = "10.1016/j.heliyon.2017.e00440",

language = "English",

volume = "3",

journal = "Heliyon",

issn = "2405-8440",

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TY - JOUR

T1 - Organomegaly in Mali before and after praziquantel treatment. A possible association with Schistosoma haematobium

AU - Stecher, Chalotte Willemann

AU - Madsen, Henry

AU - Wilson, Shona

AU - Sacko, Moussa

AU - Wejse, Christian

AU - Keita, Adama D.

AU - Landouré, Aly

AU - Traoré, Mamadou S.

AU - Kallestrup, Per

AU - Petersen, Eskild

AU - Vennervald, Birgitte

PY - 2017/11

Y1 - 2017/11

N2 - Continuous exposure to schistosome-infested water results in acute and chronic morbidity in all ages. We analysed occurence of organomegaly via ultrasonography and investigated a possible additive effect of dual-dose drug administration in 401 Schistosoma haematobium infected individuals from a highly endemic area in Mali. Mean intensity of infection at baseline (22.0 eggs per 10 ml) was reduced to 0.22 eggs per 10 ml 9 weeks after treatment (both treatments combined). Odds of persistent infection among those given dual-dose treatment was 41% of that in people given single dose (b = 0.41; p = 0.05; 95% CI 0.17–1.00), but after two years, 70.7% of the 157 participants, who completed the survey, were re-infected with no significant difference in prevalence and intensity of infection between treatment groups. Resolution of organomegaly occurred in all age groups after treatment. A novel association between Schistosoma haematobium infection and moderate portal vein enlargement was found in 35% (n: 55). Severe portal vein diameter enlargement was found in 3.2%. After two years, moderate hepatomegaly was present in 50.6%, moderate splenomegaly in 45.6% and moderate portal vein diameter enlargement in 19%. A subsequent dose of PZQ did not provide any additional long-term advantages.

AB - Continuous exposure to schistosome-infested water results in acute and chronic morbidity in all ages. We analysed occurence of organomegaly via ultrasonography and investigated a possible additive effect of dual-dose drug administration in 401 Schistosoma haematobium infected individuals from a highly endemic area in Mali. Mean intensity of infection at baseline (22.0 eggs per 10 ml) was reduced to 0.22 eggs per 10 ml 9 weeks after treatment (both treatments combined). Odds of persistent infection among those given dual-dose treatment was 41% of that in people given single dose (b = 0.41; p = 0.05; 95% CI 0.17–1.00), but after two years, 70.7% of the 157 participants, who completed the survey, were re-infected with no significant difference in prevalence and intensity of infection between treatment groups. Resolution of organomegaly occurred in all age groups after treatment. A novel association between Schistosoma haematobium infection and moderate portal vein enlargement was found in 35% (n: 55). Severe portal vein diameter enlargement was found in 3.2%. After two years, moderate hepatomegaly was present in 50.6%, moderate splenomegaly in 45.6% and moderate portal vein diameter enlargement in 19%. A subsequent dose of PZQ did not provide any additional long-term advantages.

KW - Infectious disease

U2 - 10.1016/j.heliyon.2017.e00440

DO - 10.1016/j.heliyon.2017.e00440

M3 - Journal article

C2 - 29264407

AN - SCOPUS:85033726971

SN - 2405-8440

VL - 3

JO - Heliyon

JF - Heliyon

IS - 11

M1 - e00440

ER -

Organomegaly in Mali before and after praziquantel treatment. A possible association with Schistosoma haematobium

Abstract

Keywords

UN SDGs

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