Oral manganese for liver imaging at three different field strengths

Henrik S. Thomsen; Vibeke Loegager; Henrik Noergaard; Elizaveta Chabanova; Jakob M. Moller; Jesper Sonne

doi:10.1016/j.acra.2004.01.004

Oral manganese for liver imaging at three different field strengths

Henrik S. Thomsen^*, Vibeke Loegager, Henrik Noergaard, Elizaveta Chabanova, Jakob M. Moller, Jesper Sonne

^*Corresponding author for this work

Department of Clinical Medicine

13 Citations (Scopus)

Abstract

Rationale and Objectives. To study the magnetic resonance imaging signal intensity of the liver and gall bladder before and after ingestion of a new oral manganese containing contrast medium at three different field strengths. Materials and Methods. Twelve healthy male volunteers (mean age, 24.9 years; range, 20-39 years) underwent abdominal magnetic resonance imaging (T ₂W COR, T₁W COR, T₁W TRA) at 0.23T, 0.6T, and 1.5 T before and after the contrast administration. The duration of fasting was identical before the two studies. Volunteers were randomized into two equal groups (n = 6) to ingest either half or full strength CMC-001 providing either 0.8 or 1.6.g MnCl₂ plus absorption promoters. The CMC-001 dose was dissolved in 400 mL water and ingested 21/2 hours before imaging. The resulting images were evaluated with regard to visualization of the liver and the gall bladder by three radiologists. The signal intensity of the liver was also measured. Blood and urine samples were collected before and after ingestion of CMC-001. Results. The intake of CMC-001 caused a significant increase in the signal intensity of the liver at all three field strengths and at both dosages (up to 90%) on the T₁W images. The internal structure of the liver was significantly better delineated. The bile in gall bladder was bright after ingestion of the low dose, but dark after the full dose. On the T₂W images, CMC-001 lowered the signal intensity of liver with up to 30%. CMC-001 had a slight metallic taste, but of no importance according to the volunteers. No systematic adverse reactions caused by the contrast medium were registered. No changes in the blood levels of various routine parameters were measured. Conclusion. It is possible to increase the signal intensity of the liver significantly by oral intake of essential nutritional elements including manganese. The imaging window is more than 2 hours.

Original language	English
Journal	Academic Radiology
Volume	11
Issue number	6
Pages (from-to)	630-636
Number of pages	7
ISSN	1076-6332
DOIs	https://doi.org/10.1016/j.acra.2004.01.004
Publication status	Published - 1 Jan 2004

Keywords

Contrast media
Gall bladder
Liver
Magnetic resonance imaging (MRI)
Oral manganese

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10.1016/j.acra.2004.01.004

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title = "Oral manganese for liver imaging at three different field strengths",

abstract = "Rationale and Objectives. To study the magnetic resonance imaging signal intensity of the liver and gall bladder before and after ingestion of a new oral manganese containing contrast medium at three different field strengths. Materials and Methods. Twelve healthy male volunteers (mean age, 24.9 years; range, 20-39 years) underwent abdominal magnetic resonance imaging (T 2W COR, T1W COR, T1W TRA) at 0.23T, 0.6T, and 1.5 T before and after the contrast administration. The duration of fasting was identical before the two studies. Volunteers were randomized into two equal groups (n = 6) to ingest either half or full strength CMC-001 providing either 0.8 or 1.6.g MnCl2 plus absorption promoters. The CMC-001 dose was dissolved in 400 mL water and ingested 21/2 hours before imaging. The resulting images were evaluated with regard to visualization of the liver and the gall bladder by three radiologists. The signal intensity of the liver was also measured. Blood and urine samples were collected before and after ingestion of CMC-001. Results. The intake of CMC-001 caused a significant increase in the signal intensity of the liver at all three field strengths and at both dosages (up to 90%) on the T1W images. The internal structure of the liver was significantly better delineated. The bile in gall bladder was bright after ingestion of the low dose, but dark after the full dose. On the T2W images, CMC-001 lowered the signal intensity of liver with up to 30%. CMC-001 had a slight metallic taste, but of no importance according to the volunteers. No systematic adverse reactions caused by the contrast medium were registered. No changes in the blood levels of various routine parameters were measured. Conclusion. It is possible to increase the signal intensity of the liver significantly by oral intake of essential nutritional elements including manganese. The imaging window is more than 2 hours.",

keywords = "Contrast media, Gall bladder, Liver, Magnetic resonance imaging (MRI), Oral manganese",

author = "Thomsen, {Henrik S.} and Vibeke Loegager and Henrik Noergaard and Elizaveta Chabanova and Moller, {Jakob M.} and Jesper Sonne",

year = "2004",

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doi = "10.1016/j.acra.2004.01.004",

language = "English",

volume = "11",

pages = "630--636",

journal = "Academic Radiology",

issn = "1076-6332",

publisher = "Elsevier",

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TY - JOUR

T1 - Oral manganese for liver imaging at three different field strengths

AU - Thomsen, Henrik S.

AU - Loegager, Vibeke

AU - Noergaard, Henrik

AU - Chabanova, Elizaveta

AU - Moller, Jakob M.

AU - Sonne, Jesper

PY - 2004/1/1

Y1 - 2004/1/1

N2 - Rationale and Objectives. To study the magnetic resonance imaging signal intensity of the liver and gall bladder before and after ingestion of a new oral manganese containing contrast medium at three different field strengths. Materials and Methods. Twelve healthy male volunteers (mean age, 24.9 years; range, 20-39 years) underwent abdominal magnetic resonance imaging (T 2W COR, T1W COR, T1W TRA) at 0.23T, 0.6T, and 1.5 T before and after the contrast administration. The duration of fasting was identical before the two studies. Volunteers were randomized into two equal groups (n = 6) to ingest either half or full strength CMC-001 providing either 0.8 or 1.6.g MnCl2 plus absorption promoters. The CMC-001 dose was dissolved in 400 mL water and ingested 21/2 hours before imaging. The resulting images were evaluated with regard to visualization of the liver and the gall bladder by three radiologists. The signal intensity of the liver was also measured. Blood and urine samples were collected before and after ingestion of CMC-001. Results. The intake of CMC-001 caused a significant increase in the signal intensity of the liver at all three field strengths and at both dosages (up to 90%) on the T1W images. The internal structure of the liver was significantly better delineated. The bile in gall bladder was bright after ingestion of the low dose, but dark after the full dose. On the T2W images, CMC-001 lowered the signal intensity of liver with up to 30%. CMC-001 had a slight metallic taste, but of no importance according to the volunteers. No systematic adverse reactions caused by the contrast medium were registered. No changes in the blood levels of various routine parameters were measured. Conclusion. It is possible to increase the signal intensity of the liver significantly by oral intake of essential nutritional elements including manganese. The imaging window is more than 2 hours.

AB - Rationale and Objectives. To study the magnetic resonance imaging signal intensity of the liver and gall bladder before and after ingestion of a new oral manganese containing contrast medium at three different field strengths. Materials and Methods. Twelve healthy male volunteers (mean age, 24.9 years; range, 20-39 years) underwent abdominal magnetic resonance imaging (T 2W COR, T1W COR, T1W TRA) at 0.23T, 0.6T, and 1.5 T before and after the contrast administration. The duration of fasting was identical before the two studies. Volunteers were randomized into two equal groups (n = 6) to ingest either half or full strength CMC-001 providing either 0.8 or 1.6.g MnCl2 plus absorption promoters. The CMC-001 dose was dissolved in 400 mL water and ingested 21/2 hours before imaging. The resulting images were evaluated with regard to visualization of the liver and the gall bladder by three radiologists. The signal intensity of the liver was also measured. Blood and urine samples were collected before and after ingestion of CMC-001. Results. The intake of CMC-001 caused a significant increase in the signal intensity of the liver at all three field strengths and at both dosages (up to 90%) on the T1W images. The internal structure of the liver was significantly better delineated. The bile in gall bladder was bright after ingestion of the low dose, but dark after the full dose. On the T2W images, CMC-001 lowered the signal intensity of liver with up to 30%. CMC-001 had a slight metallic taste, but of no importance according to the volunteers. No systematic adverse reactions caused by the contrast medium were registered. No changes in the blood levels of various routine parameters were measured. Conclusion. It is possible to increase the signal intensity of the liver significantly by oral intake of essential nutritional elements including manganese. The imaging window is more than 2 hours.

KW - Contrast media

KW - Gall bladder

KW - Liver

KW - Magnetic resonance imaging (MRI)

KW - Oral manganese

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U2 - 10.1016/j.acra.2004.01.004

DO - 10.1016/j.acra.2004.01.004

M3 - Journal article

C2 - 15172365

AN - SCOPUS:2542483591

SN - 1076-6332

VL - 11

SP - 630

EP - 636

JO - Academic Radiology

JF - Academic Radiology

IS - 6

ER -

Oral manganese for liver imaging at three different field strengths

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Keywords

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