Oligoclonal band phenotypes in MS differ in their HLA class II association, while specific KIR ligands at HLA class I show association to MS in general

Marte W Gustavsen; Marte K Viken; Elisabeth G Celius; Tone Berge; Inger-Lise Mero; Pål Berg-Hansen; Jan H Aarseth; Kjell-Morten Myhr; Helle B Søndergaard; Finn Sellebjerg; Annette B Oturai; Jan Hillert; Lars Alfredsson; Tomas Olsson; Ingrid Kockum; Benedicte A Lie; Hanne F Harbo

doi:10.1016/j.jneuroim.2014.06.024

Oligoclonal band phenotypes in MS differ in their HLA class II association, while specific KIR ligands at HLA class I show association to MS in general

Marte W Gustavsen, Marte K Viken, Elisabeth G Celius, Tone Berge, Inger-Lise Mero, Pål Berg-Hansen, Jan H Aarseth, Kjell-Morten Myhr, Helle B Søndergaard, Finn Sellebjerg, Annette B Oturai, Jan Hillert, Lars Alfredsson, Tomas Olsson, Ingrid Kockum, Benedicte A Lie, Hanne F Harbo

Department of Clinical Medicine

4 Citations (Scopus)

Abstract

Multiple sclerosis (MS) patients have been reported to have different HLA class II allele profiles depending on oligoclonal bands (OCBs) in the cerebrospinal fluid, but HLA class I alleles and killer cell immunoglobulin-like receptor (KIR) ligands have not been studied. We investigated the association of HLA alleles and KIR ligands according to OCB status in MS patients (n=3876). Specific KIR ligands were associated with patients when compared to controls (n=3148), supporting a role for NK cells in MS pathogenesis. HLA class I alleles and KIR ligands did not differ between OCB phenotypes, but HLA class II associations were convincingly replicated.

Original language	English
Journal	Journal of Neuroimmunology
Volume	274
Issue number	1-2
Pages (from-to)	174-179
Number of pages	6
ISSN	0165-5728
DOIs	https://doi.org/10.1016/j.jneuroim.2014.06.024
Publication status	Published - 15 Sept 2014

Keywords

Adult
Female
HLA-DRB1 Chains
Haplotypes
Histocompatibility Antigens Class I
Histocompatibility Antigens Class II
Humans
Killer Cells, Natural
Ligands
Male
Multiple Sclerosis, Relapsing-Remitting
Oligoclonal Bands
Phenotype
Receptors, KIR2DL1
Receptors, KIR2DL2
Receptors, KIR2DL3
Registries

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10.1016/j.jneuroim.2014.06.024

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Gustavsen, M. W., Viken, M. K., Celius, E. G., Berge, T., Mero, I-L., Berg-Hansen, P., Aarseth, J. H., Myhr, K-M., Søndergaard, H. B., Sellebjerg, F., Oturai, A. B., Hillert, J., Alfredsson, L., Olsson, T., Kockum, I., Lie, B. A., & Harbo, H. F. (2014). Oligoclonal band phenotypes in MS differ in their HLA class II association, while specific KIR ligands at HLA class I show association to MS in general. Journal of Neuroimmunology, 274(1-2), 174-179. https://doi.org/10.1016/j.jneuroim.2014.06.024

Oligoclonal band phenotypes in MS differ in their HLA class II association, while specific KIR ligands at HLA class I show association to MS in general. / Gustavsen, Marte W; Viken, Marte K; Celius, Elisabeth G et al.

In: Journal of Neuroimmunology, Vol. 274, No. 1-2, 15.09.2014, p. 174-179.

Research output: Contribution to journal › Journal article › Research › peer-review

Gustavsen, MW, Viken, MK, Celius, EG, Berge, T, Mero, I-L, Berg-Hansen, P, Aarseth, JH, Myhr, K-M, Søndergaard, HB, Sellebjerg, F, Oturai, AB, Hillert, J, Alfredsson, L, Olsson, T, Kockum, I, Lie, BA & Harbo, HF 2014, 'Oligoclonal band phenotypes in MS differ in their HLA class II association, while specific KIR ligands at HLA class I show association to MS in general', Journal of Neuroimmunology, vol. 274, no. 1-2, pp. 174-179. https://doi.org/10.1016/j.jneuroim.2014.06.024

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abstract = "Multiple sclerosis (MS) patients have been reported to have different HLA class II allele profiles depending on oligoclonal bands (OCBs) in the cerebrospinal fluid, but HLA class I alleles and killer cell immunoglobulin-like receptor (KIR) ligands have not been studied. We investigated the association of HLA alleles and KIR ligands according to OCB status in MS patients (n=3876). Specific KIR ligands were associated with patients when compared to controls (n=3148), supporting a role for NK cells in MS pathogenesis. HLA class I alleles and KIR ligands did not differ between OCB phenotypes, but HLA class II associations were convincingly replicated.",

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AU - Gustavsen, Marte W

AU - Viken, Marte K

AU - Celius, Elisabeth G

AU - Berge, Tone

AU - Mero, Inger-Lise

AU - Berg-Hansen, Pål

AU - Aarseth, Jan H

AU - Myhr, Kjell-Morten

AU - Søndergaard, Helle B

AU - Sellebjerg, Finn

AU - Oturai, Annette B

AU - Hillert, Jan

AU - Alfredsson, Lars

AU - Olsson, Tomas

AU - Kockum, Ingrid

AU - Lie, Benedicte A

AU - Harbo, Hanne F

PY - 2014/9/15

Y1 - 2014/9/15

N2 - Multiple sclerosis (MS) patients have been reported to have different HLA class II allele profiles depending on oligoclonal bands (OCBs) in the cerebrospinal fluid, but HLA class I alleles and killer cell immunoglobulin-like receptor (KIR) ligands have not been studied. We investigated the association of HLA alleles and KIR ligands according to OCB status in MS patients (n=3876). Specific KIR ligands were associated with patients when compared to controls (n=3148), supporting a role for NK cells in MS pathogenesis. HLA class I alleles and KIR ligands did not differ between OCB phenotypes, but HLA class II associations were convincingly replicated.

AB - Multiple sclerosis (MS) patients have been reported to have different HLA class II allele profiles depending on oligoclonal bands (OCBs) in the cerebrospinal fluid, but HLA class I alleles and killer cell immunoglobulin-like receptor (KIR) ligands have not been studied. We investigated the association of HLA alleles and KIR ligands according to OCB status in MS patients (n=3876). Specific KIR ligands were associated with patients when compared to controls (n=3148), supporting a role for NK cells in MS pathogenesis. HLA class I alleles and KIR ligands did not differ between OCB phenotypes, but HLA class II associations were convincingly replicated.

KW - Adult

KW - Female

KW - HLA-DRB1 Chains

KW - Haplotypes

KW - Histocompatibility Antigens Class I

KW - Histocompatibility Antigens Class II

KW - Humans

KW - Killer Cells, Natural

KW - Ligands

KW - Male

KW - Multiple Sclerosis, Relapsing-Remitting

KW - Oligoclonal Bands

KW - Phenotype

KW - Receptors, KIR2DL1

KW - Receptors, KIR2DL2

KW - Receptors, KIR2DL3

KW - Registries

U2 - 10.1016/j.jneuroim.2014.06.024

DO - 10.1016/j.jneuroim.2014.06.024

M3 - Journal article

C2 - 25037176

SN - 0165-5728

VL - 274

SP - 174

EP - 179

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Oligoclonal band phenotypes in MS differ in their HLA class II association, while specific KIR ligands at HLA class I show association to MS in general

Abstract

Keywords

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