TY - JOUR
T1 - Occurrence of cancer in a cohort of 183 persons with constitutional chromosome 7 abnormalities
AU - Hasle, H
AU - Olsen, J H
AU - Hansen, J
AU - Friedrich, U
AU - Tommerup, Niels
N1 - Keywords: Adult; Aged; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human, Pair 7; Cohort Studies; Denmark; Female; Follow-Up Studies; Genes, Tumor Suppressor; Humans; Karyotyping; Male; Middle Aged; Neoplasms; Risk
PY - 1998
Y1 - 1998
N2 - Cytogenetic abnormalities in human malignancies frequently involve chromosome 7. The existence of several tumor suppressor genes on the long arm of chromosome 7 has been suggested in both epithelial and hematologic malignancies. From the Danish Cytogenetic Register, we identified 183 persons with constitutional abnormalities involving chromosome 7, including 16 patients with Williams syndrome. By linkage to the Danish Cancer Registry, we found five persons with cancer, including one thyroid carcinoma, three carcinomas of the digestive tract, and one malignant melanoma. There were no cases of leukemia. The overall risk of developing cancer was not increased.
AB - Cytogenetic abnormalities in human malignancies frequently involve chromosome 7. The existence of several tumor suppressor genes on the long arm of chromosome 7 has been suggested in both epithelial and hematologic malignancies. From the Danish Cytogenetic Register, we identified 183 persons with constitutional abnormalities involving chromosome 7, including 16 patients with Williams syndrome. By linkage to the Danish Cancer Registry, we found five persons with cancer, including one thyroid carcinoma, three carcinomas of the digestive tract, and one malignant melanoma. There were no cases of leukemia. The overall risk of developing cancer was not increased.
M3 - Journal article
C2 - 9689928
SN - 2210-7762
VL - 105
SP - 39
EP - 42
JO - Cancer genetics and cytogenetics
JF - Cancer genetics and cytogenetics
IS - 1
ER -
