Occupational exposure to solvents and acute myeloid leukemia: a population-based, case-control study in four Nordic countries

Madar Talibov; Susanna Lehtinen-Jacks; Jan Ivar Martinsen; Kristina Kjærheim; Elsebeth Lynge; Pär Sparén; Laufey Tryggvadottir; Elisabete Weiderpass; Timo Kauppinen; Pentti Kyyrönen; Eero Pukkala

doi:10.5271/sjweh.3436

Occupational exposure to solvents and acute myeloid leukemia: a population-based, case-control study in four Nordic countries

Madar Talibov, Susanna Lehtinen-Jacks, Jan Ivar Martinsen, Kristina Kjærheim, Elsebeth Lynge, Pär Sparén, Laufey Tryggvadottir, Elisabete Weiderpass, Timo Kauppinen, Pentti Kyyrönen, Eero Pukkala

Center of Epidemiology and Screening

10 Citations (Scopus)

Abstract

OBJECTIVE: The aim of the current study was to assess the relation between occupational exposure to solvents and the risk of acute myeloid leukemia (AML).

METHODS: Altogether, this study comprises 15 332 incident cases of AML diagnosed in Finland, Norway, Sweden and Iceland from 1961-2005 and 76 660 controls matched by year of birth, sex, and country. Occupational records were linked with Nordic Occupational Cancer Study job exposure matrix (JEM) to estimate quantitative values for 26 occupational exposure factors. Hazard ratios (HR) with 95% confidence intervals (95% CI) were estimated by using conditional logistic regression models.

RESULTS: We did not observe statistically significantly increased risk for exposure to any of the solvents. HR estimates for high levels of toluene (HR 1.35, 95% CI 0.74-2.46), aromatic hydrocarbon solvents (ARHC) (HR 1.18, 95% CI 0.76-1.86), and moderate-to-high levels of trichloroethylene were slightly but non-significantly elevated. We did not observe an association between benzene exposure and AML in this study.

CONCLUSIONS: This study did not provide clear evidence for an association between occupational solvent exposure and AML. There was some indication for an excess risk in the groups of workers exposed to toluene, trichloroethylene and ARHC.

Original language	English
Journal	Scandinavian Journal of Work, Environment & Health
Volume	40
Issue number	5
Pages (from-to)	511-7
Number of pages	7
ISSN	0355-3140
DOIs	https://doi.org/10.5271/sjweh.3436
Publication status	Published - Sept 2014

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Talibov, M., Lehtinen-Jacks, S., Martinsen, J. I., Kjærheim, K., Lynge, E., Sparén, P., Tryggvadottir, L., Weiderpass, E., Kauppinen, T., Kyyrönen, P., & Pukkala, E. (2014). Occupational exposure to solvents and acute myeloid leukemia: a population-based, case-control study in four Nordic countries. Scandinavian Journal of Work, Environment & Health, 40(5), 511-7. https://doi.org/10.5271/sjweh.3436

Occupational exposure to solvents and acute myeloid leukemia : a population-based, case-control study in four Nordic countries. / Talibov, Madar; Lehtinen-Jacks, Susanna; Martinsen, Jan Ivar et al.

In: Scandinavian Journal of Work, Environment & Health, Vol. 40, No. 5, 09.2014, p. 511-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Talibov, M, Lehtinen-Jacks, S, Martinsen, JI, Kjærheim, K, Lynge, E, Sparén, P, Tryggvadottir, L, Weiderpass, E, Kauppinen, T, Kyyrönen, P & Pukkala, E 2014, 'Occupational exposure to solvents and acute myeloid leukemia: a population-based, case-control study in four Nordic countries', Scandinavian Journal of Work, Environment & Health, vol. 40, no. 5, pp. 511-7. https://doi.org/10.5271/sjweh.3436

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abstract = "OBJECTIVE: The aim of the current study was to assess the relation between occupational exposure to solvents and the risk of acute myeloid leukemia (AML).METHODS: Altogether, this study comprises 15 332 incident cases of AML diagnosed in Finland, Norway, Sweden and Iceland from 1961-2005 and 76 660 controls matched by year of birth, sex, and country. Occupational records were linked with Nordic Occupational Cancer Study job exposure matrix (JEM) to estimate quantitative values for 26 occupational exposure factors. Hazard ratios (HR) with 95% confidence intervals (95% CI) were estimated by using conditional logistic regression models.RESULTS: We did not observe statistically significantly increased risk for exposure to any of the solvents. HR estimates for high levels of toluene (HR 1.35, 95% CI 0.74-2.46), aromatic hydrocarbon solvents (ARHC) (HR 1.18, 95% CI 0.76-1.86), and moderate-to-high levels of trichloroethylene were slightly but non-significantly elevated. We did not observe an association between benzene exposure and AML in this study.CONCLUSIONS: This study did not provide clear evidence for an association between occupational solvent exposure and AML. There was some indication for an excess risk in the groups of workers exposed to toluene, trichloroethylene and ARHC.",

author = "Madar Talibov and Susanna Lehtinen-Jacks and Martinsen, {Jan Ivar} and Kristina Kj{\ae}rheim and Elsebeth Lynge and P{\"a}r Spar{\'e}n and Laufey Tryggvadottir and Elisabete Weiderpass and Timo Kauppinen and Pentti Kyyr{\"o}nen and Eero Pukkala",

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T1 - Occupational exposure to solvents and acute myeloid leukemia

T2 - a population-based, case-control study in four Nordic countries

AU - Talibov, Madar

AU - Lehtinen-Jacks, Susanna

AU - Martinsen, Jan Ivar

AU - Kjærheim, Kristina

AU - Lynge, Elsebeth

AU - Sparén, Pär

AU - Tryggvadottir, Laufey

AU - Weiderpass, Elisabete

AU - Kauppinen, Timo

AU - Kyyrönen, Pentti

AU - Pukkala, Eero

PY - 2014/9

Y1 - 2014/9

N2 - OBJECTIVE: The aim of the current study was to assess the relation between occupational exposure to solvents and the risk of acute myeloid leukemia (AML).METHODS: Altogether, this study comprises 15 332 incident cases of AML diagnosed in Finland, Norway, Sweden and Iceland from 1961-2005 and 76 660 controls matched by year of birth, sex, and country. Occupational records were linked with Nordic Occupational Cancer Study job exposure matrix (JEM) to estimate quantitative values for 26 occupational exposure factors. Hazard ratios (HR) with 95% confidence intervals (95% CI) were estimated by using conditional logistic regression models.RESULTS: We did not observe statistically significantly increased risk for exposure to any of the solvents. HR estimates for high levels of toluene (HR 1.35, 95% CI 0.74-2.46), aromatic hydrocarbon solvents (ARHC) (HR 1.18, 95% CI 0.76-1.86), and moderate-to-high levels of trichloroethylene were slightly but non-significantly elevated. We did not observe an association between benzene exposure and AML in this study.CONCLUSIONS: This study did not provide clear evidence for an association between occupational solvent exposure and AML. There was some indication for an excess risk in the groups of workers exposed to toluene, trichloroethylene and ARHC.

AB - OBJECTIVE: The aim of the current study was to assess the relation between occupational exposure to solvents and the risk of acute myeloid leukemia (AML).METHODS: Altogether, this study comprises 15 332 incident cases of AML diagnosed in Finland, Norway, Sweden and Iceland from 1961-2005 and 76 660 controls matched by year of birth, sex, and country. Occupational records were linked with Nordic Occupational Cancer Study job exposure matrix (JEM) to estimate quantitative values for 26 occupational exposure factors. Hazard ratios (HR) with 95% confidence intervals (95% CI) were estimated by using conditional logistic regression models.RESULTS: We did not observe statistically significantly increased risk for exposure to any of the solvents. HR estimates for high levels of toluene (HR 1.35, 95% CI 0.74-2.46), aromatic hydrocarbon solvents (ARHC) (HR 1.18, 95% CI 0.76-1.86), and moderate-to-high levels of trichloroethylene were slightly but non-significantly elevated. We did not observe an association between benzene exposure and AML in this study.CONCLUSIONS: This study did not provide clear evidence for an association between occupational solvent exposure and AML. There was some indication for an excess risk in the groups of workers exposed to toluene, trichloroethylene and ARHC.

U2 - 10.5271/sjweh.3436

DO - 10.5271/sjweh.3436

M3 - Journal article

C2 - 24840289

SN - 0355-3140

VL - 40

SP - 511

EP - 517

JO - Scandinavian Journal of Work, Environment & Health

JF - Scandinavian Journal of Work, Environment & Health

IS - 5

ER -

Occupational exposure to solvents and acute myeloid leukemia: a population-based, case-control study in four Nordic countries

Abstract

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