Occupational exposure to endocrine-disrupting chemicals and the risk of uveal melanoma

Thomas Behrens; Elsebeth Lynge; Ian Cree; Jean-Michel Lutz; Mikael Eriksson; Pascal Guénel; Franco Merletti; Maria Morales-Suarez-Varela; Noemia Afonso; Aivars Stengrevics; Andreas Stang; Joëlle Févotte; Svend Sabroe; Agustin Llopis-González; Giuseppe Gorini; Lennart Hardell; Wolfgang Ahrens

doi:10.5271/sjweh.3265

Occupational exposure to endocrine-disrupting chemicals and the risk of uveal melanoma

Thomas Behrens, Elsebeth Lynge, Ian Cree, Jean-Michel Lutz, Mikael Eriksson, Pascal Guénel, Franco Merletti, Maria Morales-Suarez-Varela, Noemia Afonso, Aivars Stengrevics, Andreas Stang, Joëlle Févotte, Svend Sabroe, Agustin Llopis-González, Giuseppe Gorini, Lennart Hardell, Wolfgang Ahrens

Center of Epidemiology and Screening

9 Citations (Scopus)

Abstract

OBJECTIVES: We investigated the association between occupational exposure to endocrine-disrupting chemicals (EDC) and the risk of uveal melanoma using international data of a case-control study from nine European countries. METHODS: After exclusion of proxy interviews, 280 cases and 3084 control subjects were included in the final analysis. Information on possible exposure to EDC was derived from 27 job-specific questionnaires (JSQ), which solicited detailed questions on occupational tasks. Relative risk estimates were based on the JSQ and potential exposure to a group of endocrine-disrupting agents. We constructed several exposure scores, taking into account intensity of exposure, use of personal protective equipment, and exposure duration. We calculated unconditional logistic regression analyses, adjusting for country, age, sex, eye color and a history of ocular damage due to intense ultraviolet (UV) exposure. RESULTS: The overall exposure prevalence to EDC was low reaching a maximum of 11% for heavy metals with endocrine-disrupting properties. Although working in some industries was associated with increased melanoma risk [such as dry cleaning: odds ratio (OR) 6.15, 95% confidence interval (95% CI) 2.0-18.96 and working in the glass manufacturing industry: OR 3.49, 95% CI 1.10-11.10], agent-specific risks were not elevated. The strongest possible risk increase was observed for organic solvents with endocrine-disrupting properties (OR 1.31, 95% CI 0.78-2.21). Calculation of exposure scores did not indicate consistently elevated results with higher score values. Sensitivity analyses did not alter these results. CONCLUSION: Occupational exposure to EDC was not associated with an increased risk for uveal melanoma.

Original language	English
Journal	Scandinavian Journal of Work, Environment & Health
Pages (from-to)	476-83
Number of pages	8
ISSN	0355-3140
DOIs	https://doi.org/10.5271/sjweh.3265
Publication status	Published - Sept 2012

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Behrens, T., Lynge, E., Cree, I., Lutz, J-M., Eriksson, M., Guénel, P., Merletti, F., Morales-Suarez-Varela, M., Afonso, N., Stengrevics, A., Stang, A., Févotte, J., Sabroe, S., Llopis-González, A., Gorini, G., Hardell, L., & Ahrens, W. (2012). Occupational exposure to endocrine-disrupting chemicals and the risk of uveal melanoma. Scandinavian Journal of Work, Environment & Health, 476-83. https://doi.org/10.5271/sjweh.3265

Behrens, T, Lynge, E, Cree, I, Lutz, J-M, Eriksson, M, Guénel, P, Merletti, F, Morales-Suarez-Varela, M, Afonso, N, Stengrevics, A, Stang, A, Févotte, J, Sabroe, S, Llopis-González, A, Gorini, G, Hardell, L & Ahrens, W 2012, 'Occupational exposure to endocrine-disrupting chemicals and the risk of uveal melanoma', Scandinavian Journal of Work, Environment & Health, pp. 476-83. https://doi.org/10.5271/sjweh.3265

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title = "Occupational exposure to endocrine-disrupting chemicals and the risk of uveal melanoma",

abstract = "OBJECTIVES: We investigated the association between occupational exposure to endocrine-disrupting chemicals (EDC) and the risk of uveal melanoma using international data of a case-control study from nine European countries. METHODS: After exclusion of proxy interviews, 280 cases and 3084 control subjects were included in the final analysis. Information on possible exposure to EDC was derived from 27 job-specific questionnaires (JSQ), which solicited detailed questions on occupational tasks. Relative risk estimates were based on the JSQ and potential exposure to a group of endocrine-disrupting agents. We constructed several exposure scores, taking into account intensity of exposure, use of personal protective equipment, and exposure duration. We calculated unconditional logistic regression analyses, adjusting for country, age, sex, eye color and a history of ocular damage due to intense ultraviolet (UV) exposure. RESULTS: The overall exposure prevalence to EDC was low reaching a maximum of 11% for heavy metals with endocrine-disrupting properties. Although working in some industries was associated with increased melanoma risk [such as dry cleaning: odds ratio (OR) 6.15, 95% confidence interval (95% CI) 2.0-18.96 and working in the glass manufacturing industry: OR 3.49, 95% CI 1.10-11.10], agent-specific risks were not elevated. The strongest possible risk increase was observed for organic solvents with endocrine-disrupting properties (OR 1.31, 95% CI 0.78-2.21). Calculation of exposure scores did not indicate consistently elevated results with higher score values. Sensitivity analyses did not alter these results. CONCLUSION: Occupational exposure to EDC was not associated with an increased risk for uveal melanoma.",

author = "Thomas Behrens and Elsebeth Lynge and Ian Cree and Jean-Michel Lutz and Mikael Eriksson and Pascal Gu{\'e}nel and Franco Merletti and Maria Morales-Suarez-Varela and Noemia Afonso and Aivars Stengrevics and Andreas Stang and Jo{\"e}lle F{\'e}votte and Svend Sabroe and Agustin Llopis-Gonz{\'a}lez and Giuseppe Gorini and Lennart Hardell and Wolfgang Ahrens",

year = "2012",

month = sep,

doi = "10.5271/sjweh.3265",

language = "English",

pages = "476--83",

journal = "Scandinavian Journal of Work, Environment & Health",

issn = "0355-3140",

publisher = "Tyoterveyslaitos",

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TY - JOUR

T1 - Occupational exposure to endocrine-disrupting chemicals and the risk of uveal melanoma

AU - Behrens, Thomas

AU - Lynge, Elsebeth

AU - Cree, Ian

AU - Lutz, Jean-Michel

AU - Eriksson, Mikael

AU - Guénel, Pascal

AU - Merletti, Franco

AU - Morales-Suarez-Varela, Maria

AU - Afonso, Noemia

AU - Stengrevics, Aivars

AU - Stang, Andreas

AU - Févotte, Joëlle

AU - Sabroe, Svend

AU - Llopis-González, Agustin

AU - Gorini, Giuseppe

AU - Hardell, Lennart

AU - Ahrens, Wolfgang

PY - 2012/9

Y1 - 2012/9

N2 - OBJECTIVES: We investigated the association between occupational exposure to endocrine-disrupting chemicals (EDC) and the risk of uveal melanoma using international data of a case-control study from nine European countries. METHODS: After exclusion of proxy interviews, 280 cases and 3084 control subjects were included in the final analysis. Information on possible exposure to EDC was derived from 27 job-specific questionnaires (JSQ), which solicited detailed questions on occupational tasks. Relative risk estimates were based on the JSQ and potential exposure to a group of endocrine-disrupting agents. We constructed several exposure scores, taking into account intensity of exposure, use of personal protective equipment, and exposure duration. We calculated unconditional logistic regression analyses, adjusting for country, age, sex, eye color and a history of ocular damage due to intense ultraviolet (UV) exposure. RESULTS: The overall exposure prevalence to EDC was low reaching a maximum of 11% for heavy metals with endocrine-disrupting properties. Although working in some industries was associated with increased melanoma risk [such as dry cleaning: odds ratio (OR) 6.15, 95% confidence interval (95% CI) 2.0-18.96 and working in the glass manufacturing industry: OR 3.49, 95% CI 1.10-11.10], agent-specific risks were not elevated. The strongest possible risk increase was observed for organic solvents with endocrine-disrupting properties (OR 1.31, 95% CI 0.78-2.21). Calculation of exposure scores did not indicate consistently elevated results with higher score values. Sensitivity analyses did not alter these results. CONCLUSION: Occupational exposure to EDC was not associated with an increased risk for uveal melanoma.

AB - OBJECTIVES: We investigated the association between occupational exposure to endocrine-disrupting chemicals (EDC) and the risk of uveal melanoma using international data of a case-control study from nine European countries. METHODS: After exclusion of proxy interviews, 280 cases and 3084 control subjects were included in the final analysis. Information on possible exposure to EDC was derived from 27 job-specific questionnaires (JSQ), which solicited detailed questions on occupational tasks. Relative risk estimates were based on the JSQ and potential exposure to a group of endocrine-disrupting agents. We constructed several exposure scores, taking into account intensity of exposure, use of personal protective equipment, and exposure duration. We calculated unconditional logistic regression analyses, adjusting for country, age, sex, eye color and a history of ocular damage due to intense ultraviolet (UV) exposure. RESULTS: The overall exposure prevalence to EDC was low reaching a maximum of 11% for heavy metals with endocrine-disrupting properties. Although working in some industries was associated with increased melanoma risk [such as dry cleaning: odds ratio (OR) 6.15, 95% confidence interval (95% CI) 2.0-18.96 and working in the glass manufacturing industry: OR 3.49, 95% CI 1.10-11.10], agent-specific risks were not elevated. The strongest possible risk increase was observed for organic solvents with endocrine-disrupting properties (OR 1.31, 95% CI 0.78-2.21). Calculation of exposure scores did not indicate consistently elevated results with higher score values. Sensitivity analyses did not alter these results. CONCLUSION: Occupational exposure to EDC was not associated with an increased risk for uveal melanoma.

U2 - 10.5271/sjweh.3265

DO - 10.5271/sjweh.3265

M3 - Journal article

C2 - 22179223

SN - 0355-3140

SP - 476

EP - 483

JO - Scandinavian Journal of Work, Environment & Health

JF - Scandinavian Journal of Work, Environment & Health

ER -

Occupational exposure to endocrine-disrupting chemicals and the risk of uveal melanoma

Abstract

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