Objectively measured physical activity and sedentary time are associated with cardiometabolic risk factors in adults with prediabetes: The PREVIEW Study

Nils Swindell; Kelly Mackintosh; Melitta McNarry; Jeffrey W Stephens; Diewertje Sluik; Mikael Fogelholm; Mathijs Drummen; Ian MacDonald; J Alfredo Martinez; Teodora Handjieva-Darlenska; Sally D Poppitt; Jennie Brand-Miller; Thomas Meinert Larsen; Anne Raben; Gareth Stratton

doi:10.2337/dc17-1057

Objectively measured physical activity and sedentary time are associated with cardiometabolic risk factors in adults with prediabetes: The PREVIEW Study

Nils Swindell, Kelly Mackintosh, Melitta McNarry, Jeffrey W Stephens, Diewertje Sluik, Mikael Fogelholm, Mathijs Drummen, Ian MacDonald, J Alfredo Martinez, Teodora Handjieva-Darlenska, Sally D Poppitt, Jennie Brand-Miller, Thomas Meinert Larsen, Anne Raben, Gareth Stratton

Obesity Research

9 Citations (Scopus)

Abstract

OBJECTIVE The aim of the present cross-sectional study was to examine the association among physical activity (PA), sedentary time (ST), and cardiometabolic risk in adults with prediabetes. RESEARCH DESIGN AND METHODS Participants (n = 2,326; 25-70 years old, 67% female) from eight countries, with a BMI >25 kg · m22 and impaired fasting glucose (5.6-6.9 mmol · L21) or impaired glucose tolerance (7.8-11.0 mmol · L21 at 2 h), participated. Seven-day accelerometry objectively assessed PA levels and ST. RESULTS Multiple linear regression revealed that moderate-To-vigorous PA (MVPA) was negatively associated withHOMAof insulin resistance (HOMA-IR) (standardizedb =20.078 [95% CI20.128,20.027]), waist circumference (WC) (b =20.177 [20.122,20.134]), fasting insulin (b = 20.115 [20.158, 20.072]), 2-h glucose (b = 20.069 [20.112, 20.025]), triglycerides (b = 20.091 [20.138, 20.044]), and CRP (b = 20.086 [20.127, 20.045]). ST was positively associated with HOMA-IR (b = 0.175 [0.114, 0.236]), WC (b = 0.215 [0.026, 0.131]), fasting insulin (b = 0.155 [0.092, 0.219]), triglycerides (b = 0.106 [0.052, 0.16]), CRP (b = 0.106 [0.39, 0.172]), systolic blood pressure (BP) (b = 0.078 [0.026, 0.131]), and diastolic BP (b = 0.106 [0.39, 20.172]). Associations reported between total PA (counts · min21), and all risk factors were comparable or stronger than for MVPA: HOMA-IR (b = 20.151 [20.194, 20.107]), WC (b = 20.179 [20.224, 20.134]), fasting insulin (b = 20.139 [20.183, 20.096]), 2-h glucose (b = 20.088 [20.131, 20.045]), triglycerides (b = 20.117 [20.162, 20.071]), and CRP (b = 20.104 [20.146, 20.062]). CONCLUSIONS In adults with prediabetes, objectively measured PA and ST were associated with cardiometabolic risk markers. Total PA was at least as strongly associated with cardiometabolic risk markers as MVPA, which may imply that the accumulation of total PA over the day is as important as achieving the intensity of MVPA.

Original language	English
Journal	Diabetes Care
Volume	41
Issue number	3
Pages (from-to)	562-569
Number of pages	8
ISSN	1935-5548
DOIs	https://doi.org/10.2337/dc17-1057
Publication status	Published - 1 Mar 2018

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Swindell, N., Mackintosh, K., McNarry, M., Stephens, J. W., Sluik, D., Fogelholm, M., Drummen, M., MacDonald, I., Martinez, J. A., Handjieva-Darlenska, T., Poppitt, S. D., Brand-Miller, J., Larsen, T. M., Raben, A., & Stratton, G. (2018). Objectively measured physical activity and sedentary time are associated with cardiometabolic risk factors in adults with prediabetes: The PREVIEW Study. Diabetes Care, 41(3), 562-569. https://doi.org/10.2337/dc17-1057

Swindell, N, Mackintosh, K, McNarry, M, Stephens, JW, Sluik, D, Fogelholm, M, Drummen, M, MacDonald, I, Martinez, JA, Handjieva-Darlenska, T, Poppitt, SD, Brand-Miller, J, Larsen, TM, Raben, A & Stratton, G 2018, 'Objectively measured physical activity and sedentary time are associated with cardiometabolic risk factors in adults with prediabetes: The PREVIEW Study', Diabetes Care, vol. 41, no. 3, pp. 562-569. https://doi.org/10.2337/dc17-1057

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title = "Objectively measured physical activity and sedentary time are associated with cardiometabolic risk factors in adults with prediabetes: The PREVIEW Study",

abstract = "OBJECTIVE The aim of the present cross-sectional study was to examine the association among physical activity (PA), sedentary time (ST), and cardiometabolic risk in adults with prediabetes. RESEARCH DESIGN AND METHODS Participants (n = 2,326; 25-70 years old, 67% female) from eight countries, with a BMI >25 kg · m22 and impaired fasting glucose (5.6-6.9 mmol · L21) or impaired glucose tolerance (7.8-11.0 mmol · L21 at 2 h), participated. Seven-day accelerometry objectively assessed PA levels and ST. RESULTS Multiple linear regression revealed that moderate-To-vigorous PA (MVPA) was negatively associated withHOMAof insulin resistance (HOMA-IR) (standardizedb =20.078 [95% CI20.128,20.027]), waist circumference (WC) (b =20.177 [20.122,20.134]), fasting insulin (b = 20.115 [20.158, 20.072]), 2-h glucose (b = 20.069 [20.112, 20.025]), triglycerides (b = 20.091 [20.138, 20.044]), and CRP (b = 20.086 [20.127, 20.045]). ST was positively associated with HOMA-IR (b = 0.175 [0.114, 0.236]), WC (b = 0.215 [0.026, 0.131]), fasting insulin (b = 0.155 [0.092, 0.219]), triglycerides (b = 0.106 [0.052, 0.16]), CRP (b = 0.106 [0.39, 0.172]), systolic blood pressure (BP) (b = 0.078 [0.026, 0.131]), and diastolic BP (b = 0.106 [0.39, 20.172]). Associations reported between total PA (counts · min21), and all risk factors were comparable or stronger than for MVPA: HOMA-IR (b = 20.151 [20.194, 20.107]), WC (b = 20.179 [20.224, 20.134]), fasting insulin (b = 20.139 [20.183, 20.096]), 2-h glucose (b = 20.088 [20.131, 20.045]), triglycerides (b = 20.117 [20.162, 20.071]), and CRP (b = 20.104 [20.146, 20.062]). CONCLUSIONS In adults with prediabetes, objectively measured PA and ST were associated with cardiometabolic risk markers. Total PA was at least as strongly associated with cardiometabolic risk markers as MVPA, which may imply that the accumulation of total PA over the day is as important as achieving the intensity of MVPA.",

keywords = "Journal Article",

author = "Nils Swindell and Kelly Mackintosh and Melitta McNarry and Stephens, {Jeffrey W} and Diewertje Sluik and Mikael Fogelholm and Mathijs Drummen and Ian MacDonald and Martinez, {J Alfredo} and Teodora Handjieva-Darlenska and Poppitt, {Sally D} and Jennie Brand-Miller and Larsen, {Thomas Meinert} and Anne Raben and Gareth Stratton",

note = "CURIS 2018 NEXS 088",

year = "2018",

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doi = "10.2337/dc17-1057",

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TY - JOUR

T1 - Objectively measured physical activity and sedentary time are associated with cardiometabolic risk factors in adults with prediabetes

T2 - The PREVIEW Study

AU - Swindell, Nils

AU - Mackintosh, Kelly

AU - McNarry, Melitta

AU - Stephens, Jeffrey W

AU - Sluik, Diewertje

AU - Fogelholm, Mikael

AU - Drummen, Mathijs

AU - MacDonald, Ian

AU - Martinez, J Alfredo

AU - Handjieva-Darlenska, Teodora

AU - Poppitt, Sally D

AU - Brand-Miller, Jennie

AU - Larsen, Thomas Meinert

AU - Raben, Anne

AU - Stratton, Gareth

N1 - CURIS 2018 NEXS 088

PY - 2018/3/1

Y1 - 2018/3/1

N2 - OBJECTIVE The aim of the present cross-sectional study was to examine the association among physical activity (PA), sedentary time (ST), and cardiometabolic risk in adults with prediabetes. RESEARCH DESIGN AND METHODS Participants (n = 2,326; 25-70 years old, 67% female) from eight countries, with a BMI >25 kg · m22 and impaired fasting glucose (5.6-6.9 mmol · L21) or impaired glucose tolerance (7.8-11.0 mmol · L21 at 2 h), participated. Seven-day accelerometry objectively assessed PA levels and ST. RESULTS Multiple linear regression revealed that moderate-To-vigorous PA (MVPA) was negatively associated withHOMAof insulin resistance (HOMA-IR) (standardizedb =20.078 [95% CI20.128,20.027]), waist circumference (WC) (b =20.177 [20.122,20.134]), fasting insulin (b = 20.115 [20.158, 20.072]), 2-h glucose (b = 20.069 [20.112, 20.025]), triglycerides (b = 20.091 [20.138, 20.044]), and CRP (b = 20.086 [20.127, 20.045]). ST was positively associated with HOMA-IR (b = 0.175 [0.114, 0.236]), WC (b = 0.215 [0.026, 0.131]), fasting insulin (b = 0.155 [0.092, 0.219]), triglycerides (b = 0.106 [0.052, 0.16]), CRP (b = 0.106 [0.39, 0.172]), systolic blood pressure (BP) (b = 0.078 [0.026, 0.131]), and diastolic BP (b = 0.106 [0.39, 20.172]). Associations reported between total PA (counts · min21), and all risk factors were comparable or stronger than for MVPA: HOMA-IR (b = 20.151 [20.194, 20.107]), WC (b = 20.179 [20.224, 20.134]), fasting insulin (b = 20.139 [20.183, 20.096]), 2-h glucose (b = 20.088 [20.131, 20.045]), triglycerides (b = 20.117 [20.162, 20.071]), and CRP (b = 20.104 [20.146, 20.062]). CONCLUSIONS In adults with prediabetes, objectively measured PA and ST were associated with cardiometabolic risk markers. Total PA was at least as strongly associated with cardiometabolic risk markers as MVPA, which may imply that the accumulation of total PA over the day is as important as achieving the intensity of MVPA.

AB - OBJECTIVE The aim of the present cross-sectional study was to examine the association among physical activity (PA), sedentary time (ST), and cardiometabolic risk in adults with prediabetes. RESEARCH DESIGN AND METHODS Participants (n = 2,326; 25-70 years old, 67% female) from eight countries, with a BMI >25 kg · m22 and impaired fasting glucose (5.6-6.9 mmol · L21) or impaired glucose tolerance (7.8-11.0 mmol · L21 at 2 h), participated. Seven-day accelerometry objectively assessed PA levels and ST. RESULTS Multiple linear regression revealed that moderate-To-vigorous PA (MVPA) was negatively associated withHOMAof insulin resistance (HOMA-IR) (standardizedb =20.078 [95% CI20.128,20.027]), waist circumference (WC) (b =20.177 [20.122,20.134]), fasting insulin (b = 20.115 [20.158, 20.072]), 2-h glucose (b = 20.069 [20.112, 20.025]), triglycerides (b = 20.091 [20.138, 20.044]), and CRP (b = 20.086 [20.127, 20.045]). ST was positively associated with HOMA-IR (b = 0.175 [0.114, 0.236]), WC (b = 0.215 [0.026, 0.131]), fasting insulin (b = 0.155 [0.092, 0.219]), triglycerides (b = 0.106 [0.052, 0.16]), CRP (b = 0.106 [0.39, 0.172]), systolic blood pressure (BP) (b = 0.078 [0.026, 0.131]), and diastolic BP (b = 0.106 [0.39, 20.172]). Associations reported between total PA (counts · min21), and all risk factors were comparable or stronger than for MVPA: HOMA-IR (b = 20.151 [20.194, 20.107]), WC (b = 20.179 [20.224, 20.134]), fasting insulin (b = 20.139 [20.183, 20.096]), 2-h glucose (b = 20.088 [20.131, 20.045]), triglycerides (b = 20.117 [20.162, 20.071]), and CRP (b = 20.104 [20.146, 20.062]). CONCLUSIONS In adults with prediabetes, objectively measured PA and ST were associated with cardiometabolic risk markers. Total PA was at least as strongly associated with cardiometabolic risk markers as MVPA, which may imply that the accumulation of total PA over the day is as important as achieving the intensity of MVPA.

KW - Journal Article

U2 - 10.2337/dc17-1057

DO - 10.2337/dc17-1057

M3 - Journal article

C2 - 29158249

SN - 0149-5992

VL - 41

SP - 562

EP - 569

JO - Diabetes Care

JF - Diabetes Care

IS - 3

ER -

Objectively measured physical activity and sedentary time are associated with cardiometabolic risk factors in adults with prediabetes: The PREVIEW Study

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