NUT carcinoma presenting in the palate: a case report

TY - JOUR

T1 - NUT carcinoma presenting in the palate

T2 - a case report

AU - Bjornstrup, Libana Raffoul

AU - Reibel, Jesper

AU - Kiss, Katalin

AU - Schioedt, Morten

N1 - © 2017 APMIS. Published by John Wiley & Sons Ltd.

PY - 2017/10

Y1 - 2017/10

N2 - NUT carcinomas (NC) are rare and aggressive tumours characterized by chromosomal rearrangements of the gene encoding for nuclear protein of the testis (NUT) located on chromosome 15q14. This article presents a case of a 60-year-old woman diagnosed with NC presenting as a fast growing primary tumour in the right palate. Further evaluation revealed a tumour mass in the lungs and widespread metastases. A review of the literature did not reveal earlier cases presenting in the palate. In order to improve early diagnosis it is suggested to perform immunohistochemical testing for NUT in all poorly differentiated carcinomas without glandular differentiation arising in the chest, and head and neck (Clin Cancer Res, 18, 2012, 5773).

AB - NUT carcinomas (NC) are rare and aggressive tumours characterized by chromosomal rearrangements of the gene encoding for nuclear protein of the testis (NUT) located on chromosome 15q14. This article presents a case of a 60-year-old woman diagnosed with NC presenting as a fast growing primary tumour in the right palate. Further evaluation revealed a tumour mass in the lungs and widespread metastases. A review of the literature did not reveal earlier cases presenting in the palate. In order to improve early diagnosis it is suggested to perform immunohistochemical testing for NUT in all poorly differentiated carcinomas without glandular differentiation arising in the chest, and head and neck (Clin Cancer Res, 18, 2012, 5773).

KW - Case Reports

U2 - 10.1111/apm.12710

DO - 10.1111/apm.12710

M3 - Journal article

C2 - 28544145

SN - 0903-465X

VL - 125

SP - 933

EP - 936

JO - APMIS. Supplementum

JF - APMIS. Supplementum

IS - 10

ER -