Nuclear Gene Indicates Coat-Color Polymorphism in Mammoths

Holger Römpler; Nadin Rohland; Carles Lalueza-Fox; Eske Willerslev; Tatyana Kuznetsova; Gernot Rabeder; Jaume Bertranpetit; Torsten Schöneberg; Michael Hofreiter

doi:10.1126/science.1128994

Nuclear Gene Indicates Coat-Color Polymorphism in Mammoths

Holger Römpler, Nadin Rohland, Carles Lalueza-Fox, Eske Willerslev, Tatyana Kuznetsova, Gernot Rabeder, Jaume Bertranpetit, Torsten Schöneberg, Michael Hofreiter

111 Citations (Scopus)

Abstract

By amplifying the melanocortin type 1 receptor from the woollymammoth, we can report the complete nucleotide sequence of anuclear-encoded gene from an extinct species. We found two allelesand show that one allele produces a functional protein whereasthe other one encodes a protein with strongly reduced activity.This finding suggests that mammoths may have been polymorphicin coat color, with both dark- and light-haired individualsco-occurring.

Original language	English
Journal	Science
Volume	313
Issue number	5783
Pages (from-to)	62
ISSN	0036-8075
DOIs	https://doi.org/10.1126/science.1128994
Publication status	Published - 2006

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title = "Nuclear Gene Indicates Coat-Color Polymorphism in Mammoths",

abstract = "By amplifying the melanocortin type 1 receptor from the woolly mammoth, we can report the complete nucleotide sequence of a nuclear-encoded gene from an extinct species. We found two alleles and show that one allele produces a functional protein whereas the other one encodes a protein with strongly reduced activity. This finding suggests that mammoths may have been polymorphic in coat color, with both dark- and light-haired individuals co-occurring. ",

author = "Holger R{\"o}mpler and Nadin Rohland and Carles Lalueza-Fox and Eske Willerslev and Tatyana Kuznetsova and Gernot Rabeder and Jaume Bertranpetit and Torsten Sch{\"o}neberg and Michael Hofreiter",

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T1 - Nuclear Gene Indicates Coat-Color Polymorphism in Mammoths

AU - Römpler, Holger

AU - Rohland, Nadin

AU - Lalueza-Fox, Carles

AU - Willerslev, Eske

AU - Kuznetsova, Tatyana

AU - Rabeder, Gernot

AU - Bertranpetit, Jaume

AU - Schöneberg, Torsten

AU - Hofreiter, Michael

PY - 2006

Y1 - 2006

N2 - By amplifying the melanocortin type 1 receptor from the woolly mammoth, we can report the complete nucleotide sequence of a nuclear-encoded gene from an extinct species. We found two alleles and show that one allele produces a functional protein whereas the other one encodes a protein with strongly reduced activity. This finding suggests that mammoths may have been polymorphic in coat color, with both dark- and light-haired individuals co-occurring.

AB - By amplifying the melanocortin type 1 receptor from the woolly mammoth, we can report the complete nucleotide sequence of a nuclear-encoded gene from an extinct species. We found two alleles and show that one allele produces a functional protein whereas the other one encodes a protein with strongly reduced activity. This finding suggests that mammoths may have been polymorphic in coat color, with both dark- and light-haired individuals co-occurring.

U2 - 10.1126/science.1128994

DO - 10.1126/science.1128994

M3 - Journal article

SN - 0036-8075

VL - 313

SP - 62

JO - Science

JF - Science

IS - 5783

ER -

Nuclear Gene Indicates Coat-Color Polymorphism in Mammoths

Abstract

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