Novel Mechanisms in mTORC1-regulated Muscle Plasticity

Agnete Louise Bjerregaard Madsen

Novel Mechanisms in mTORC1-regulated Muscle Plasticity

Agnete Louise Bjerregaard Madsen

Abstract

Balanced activity of the anabolic mTORC1 signalling cascade is central to maintain skeletal muscle mass and health. Hence, it is important to understand its regulation in response to different stimuli.

In study 1, we found that mTORC1 targets were regulated differentially, depending on the stimulus such as insulin, amino acids or passive stretch in mouse muscles.

In study 2, the catabolic and anabolic signalling network in muscle was assessed by taking a global approach. Our analysis revealed a complex and intertwined network that will provide a valuable resource for future research. From this resource, a muscle-specific protein was identified as a novel target of mTORC1, linking mTORC1 to the regulation of muscle oxidative capacity in response to exercise.

Altogether, the results of this PhD thesis provide novel insights into the differentiated regulation of mTORC1 targets upon various stimuli, and they may contribute considerably in the investigation of new therapeutic targets to sustain muscle mass and health.

Original language	English

Place of Publication	Copenhagen
Publisher	Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen
Number of pages	87
ISBN (Print)	978-87-7209-211-9
Publication status	Published - 2018

Keywords

Faculty of Science
mTORC1
AMPK
ULK1
Autophagy
Skeletal muscle
Muscle plasticity
Molecular mechanisms
Cross-talk between anabolic and catabolic signalling pathways
Physical activity

Cite this

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title = "Novel Mechanisms in mTORC1-regulated Muscle Plasticity",

abstract = "Balanced activity of the anabolic mTORC1 signalling cascade is central to maintain skeletal muscle mass and health. Hence, it is important to understand its regulation in response to different stimuli.In study 1, we found that mTORC1 targets were regulated differentially, depending on the stimulus such as insulin, amino acids or passive stretch in mouse muscles.In study 2, the catabolic and anabolic signalling network in muscle was assessed by taking a global approach. Our analysis revealed a complex and intertwined network that will provide a valuable resource for future research. From this resource, a muscle-specific protein was identified as a novel target of mTORC1, linking mTORC1 to the regulation of muscle oxidative capacity in response to exercise.Altogether, the results of this PhD thesis provide novel insights into the differentiated regulation of mTORC1 targets upon various stimuli, and they may contribute considerably in the investigation of new therapeutic targets to sustain muscle mass and health.",

keywords = "Faculty of Science, mTORC1, AMPK, ULK1, Autophagy, Skeletal muscle, Muscle plasticity, Molecular mechanisms, Cross-talk between anabolic and catabolic signalling pathways, Physical activity",

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note = "CURIS 2018 NEXS 413",

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T1 - Novel Mechanisms in mTORC1-regulated Muscle Plasticity

AU - Madsen, Agnete Louise Bjerregaard

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PY - 2018

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N2 - Balanced activity of the anabolic mTORC1 signalling cascade is central to maintain skeletal muscle mass and health. Hence, it is important to understand its regulation in response to different stimuli.In study 1, we found that mTORC1 targets were regulated differentially, depending on the stimulus such as insulin, amino acids or passive stretch in mouse muscles.In study 2, the catabolic and anabolic signalling network in muscle was assessed by taking a global approach. Our analysis revealed a complex and intertwined network that will provide a valuable resource for future research. From this resource, a muscle-specific protein was identified as a novel target of mTORC1, linking mTORC1 to the regulation of muscle oxidative capacity in response to exercise.Altogether, the results of this PhD thesis provide novel insights into the differentiated regulation of mTORC1 targets upon various stimuli, and they may contribute considerably in the investigation of new therapeutic targets to sustain muscle mass and health.

AB - Balanced activity of the anabolic mTORC1 signalling cascade is central to maintain skeletal muscle mass and health. Hence, it is important to understand its regulation in response to different stimuli.In study 1, we found that mTORC1 targets were regulated differentially, depending on the stimulus such as insulin, amino acids or passive stretch in mouse muscles.In study 2, the catabolic and anabolic signalling network in muscle was assessed by taking a global approach. Our analysis revealed a complex and intertwined network that will provide a valuable resource for future research. From this resource, a muscle-specific protein was identified as a novel target of mTORC1, linking mTORC1 to the regulation of muscle oxidative capacity in response to exercise.Altogether, the results of this PhD thesis provide novel insights into the differentiated regulation of mTORC1 targets upon various stimuli, and they may contribute considerably in the investigation of new therapeutic targets to sustain muscle mass and health.

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KW - mTORC1

KW - AMPK

KW - ULK1

KW - Autophagy

KW - Skeletal muscle

KW - Muscle plasticity

KW - Molecular mechanisms

KW - Cross-talk between anabolic and catabolic signalling pathways

KW - Physical activity

M3 - Ph.D. thesis

SN - 978-87-7209-211-9

BT - Novel Mechanisms in mTORC1-regulated Muscle Plasticity

PB - Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen

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ER -

Novel Mechanisms in mTORC1-regulated Muscle Plasticity

Abstract

Keywords

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