Nordic guidelines 2014 for diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms

Eva Tiensuu Janson; Halfdan Sorbye; Staffan Welin; Birgitte Federspiel; Henning Grønbæk; Per Hellman; Morten Ladekarl; Seppo W Langer; Jann Mortensen; Camilla Schalin-Jäntti; Anders Sundin; Anna Sundlöv; Espen Thiis-Evensen; Ulrich Knigge

doi:10.3109/0284186x.2014.941999

Nordic guidelines 2014 for diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms

Eva Tiensuu Janson, Halfdan Sorbye, Staffan Welin, Birgitte Federspiel, Henning Grønbæk, Per Hellman, Morten Ladekarl, Seppo W Langer, Jann Mortensen, Camilla Schalin-Jäntti, Anders Sundin, Anna Sundlöv, Espen Thiis-Evensen, Ulrich Knigge

70 Citations (Scopus)

Abstract

BACKGROUND: The diagnostic work-up and treatment of patients with neuroendocrine neoplasms (NENs) has undergone major recent advances and new methods are currently introduced into the clinic. An update of the WHO classification has resulted in a new nomenclature dividing NENs into neuroendocrine tumours (NETs) including G1 (Ki67 index ≤ 2%) and G2 (Ki67 index 3-20%) tumours and neuroendocrine carcinomas (NECs) with Ki67 index > 20%, G3. Aim. These Nordic guidelines summarise the Nordic Neuroendocrine Tumour Group's current view on how to diagnose and treat NEN-patients and are meant to be useful in the daily practice for clinicians handling these patients.

Original language	English
Journal	Acta Oncologica
Volume	53
Issue number	10
Pages (from-to)	1284-1297
Number of pages	14
ISSN	0284-186X
DOIs	https://doi.org/10.3109/0284186x.2014.941999
Publication status	Published - 1 Oct 2014

Keywords

Antineoplastic Agents
Carcinoma, Neuroendocrine
Diagnostic Imaging
Gastrointestinal Neoplasms
Humans
Liver Neoplasms
Neuroendocrine Tumors
Pancreatic Neoplasms
Prognosis
Tumor Markers, Biological

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Janson, E. T., Sorbye, H., Welin, S., Federspiel, B., Grønbæk, H., Hellman, P., Ladekarl, M., Langer, S. W., Mortensen, J., Schalin-Jäntti, C., Sundin, A., Sundlöv, A., Thiis-Evensen, E., & Knigge, U. (2014). Nordic guidelines 2014 for diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms. Acta Oncologica, 53(10), 1284-1297. https://doi.org/10.3109/0284186x.2014.941999

Janson, ET, Sorbye, H, Welin, S, Federspiel, B, Grønbæk, H, Hellman, P, Ladekarl, M, Langer, SW , Mortensen, J, Schalin-Jäntti, C, Sundin, A, Sundlöv, A, Thiis-Evensen, E & Knigge, U 2014, 'Nordic guidelines 2014 for diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms', Acta Oncologica, vol. 53, no. 10, pp. 1284-1297. https://doi.org/10.3109/0284186x.2014.941999

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abstract = "BACKGROUND: The diagnostic work-up and treatment of patients with neuroendocrine neoplasms (NENs) has undergone major recent advances and new methods are currently introduced into the clinic. An update of the WHO classification has resulted in a new nomenclature dividing NENs into neuroendocrine tumours (NETs) including G1 (Ki67 index ≤ 2%) and G2 (Ki67 index 3-20%) tumours and neuroendocrine carcinomas (NECs) with Ki67 index > 20%, G3. Aim. These Nordic guidelines summarise the Nordic Neuroendocrine Tumour Group's current view on how to diagnose and treat NEN-patients and are meant to be useful in the daily practice for clinicians handling these patients.",

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AU - Sorbye, Halfdan

AU - Welin, Staffan

AU - Federspiel, Birgitte

AU - Grønbæk, Henning

AU - Hellman, Per

AU - Ladekarl, Morten

AU - Langer, Seppo W

AU - Mortensen, Jann

AU - Schalin-Jäntti, Camilla

AU - Sundin, Anders

AU - Sundlöv, Anna

AU - Thiis-Evensen, Espen

AU - Knigge, Ulrich

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N2 - BACKGROUND: The diagnostic work-up and treatment of patients with neuroendocrine neoplasms (NENs) has undergone major recent advances and new methods are currently introduced into the clinic. An update of the WHO classification has resulted in a new nomenclature dividing NENs into neuroendocrine tumours (NETs) including G1 (Ki67 index ≤ 2%) and G2 (Ki67 index 3-20%) tumours and neuroendocrine carcinomas (NECs) with Ki67 index > 20%, G3. Aim. These Nordic guidelines summarise the Nordic Neuroendocrine Tumour Group's current view on how to diagnose and treat NEN-patients and are meant to be useful in the daily practice for clinicians handling these patients.

AB - BACKGROUND: The diagnostic work-up and treatment of patients with neuroendocrine neoplasms (NENs) has undergone major recent advances and new methods are currently introduced into the clinic. An update of the WHO classification has resulted in a new nomenclature dividing NENs into neuroendocrine tumours (NETs) including G1 (Ki67 index ≤ 2%) and G2 (Ki67 index 3-20%) tumours and neuroendocrine carcinomas (NECs) with Ki67 index > 20%, G3. Aim. These Nordic guidelines summarise the Nordic Neuroendocrine Tumour Group's current view on how to diagnose and treat NEN-patients and are meant to be useful in the daily practice for clinicians handling these patients.

KW - Antineoplastic Agents

KW - Carcinoma, Neuroendocrine

KW - Diagnostic Imaging

KW - Gastrointestinal Neoplasms

KW - Humans

KW - Liver Neoplasms

KW - Neuroendocrine Tumors

KW - Pancreatic Neoplasms

KW - Prognosis

KW - Tumor Markers, Biological

U2 - 10.3109/0284186x.2014.941999

DO - 10.3109/0284186x.2014.941999

M3 - Review

C2 - 25140861

SN - 1100-1704

VL - 53

SP - 1284

EP - 1297

JO - Acta Oncologica, Supplement

JF - Acta Oncologica, Supplement

IS - 10

ER -

Nordic guidelines 2014 for diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms

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