No effect of the angiotensin receptor blocker candesartan on cerebrovascular autoregulation in rats during very high and low sodium intake

Sigurdur T. Sigurdsson, Peter Bie, Arne H. Nielsen, Svend Strandgaard, Olaf B. Paulson*

*Corresponding author for this work

Abstract

Autoregulation of cerebral blood flow (CBF) denotes that CBF is constant despite fluctuation of blood pressure within wide limits. Inhibition of the renin–angiotensin system (RAS) is known to decrease the lower and upper limits of CBF autoregulation. We have previously shown that this includes inhibition by the angiotensin receptor blocker (ARB) candesartan. In the present study we investigated the influence of the ARB candesartan on the lower limit of CBF autoregulation in two groups of Sprague-Dawley rats, on high (4.0% Na+) and low (0.004% Na+) sodium diet, respectively. Control animals were given the same diet, but no ARB. CBF was studied with the laser Doppler method. Blood pressure was lowered by controlled bleeding. Results revealed that both high and low sodium diet with low and high renin levels respectively block the influence of candesartan on CBF autoregulation. This was expected in rats on a high salt diet with a low renin level, but unexpected in rats with a low salt intake with a high renin level.

Original languageEnglish
JournalJRAAS - Journal of the Renin-Angiotensin-Aldosterone System
Volume20
Issue number3
Pages (from-to)1-6
ISSN1470-3203
DOIs
Publication statusPublished - Jul 2019

Keywords

  • autoregulation
  • cerebral blood flow
  • laser Doppler flow measurement
  • Renin–angiotensin system
  • sodium intake

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