No effect of melatonin on oxidative stress after laparoscopic cholecystectomy: a randomized placebo-controlled trial

B. Kucukakin; M. Klein; Jens Lykkesfeldt; R.J. Reiter; J. Rosenberg; Ismayil Gögenür

doi:10.1111/j.1399-6576.2010.02294.x

No effect of melatonin on oxidative stress after laparoscopic cholecystectomy: a randomized placebo-controlled trial

B. Kucukakin, M. Klein, Jens Lykkesfeldt, R.J. Reiter, J. Rosenberg, Ismayil Gögenür

21 Citations (Scopus)

Abstract

Background Melatonin, an endogenous circadian regulator, also has antioxidant and anti-inflammatory properties. The aim of this study was to evaluate the antioxidative effect of melatonin in patients undergoing laparoscopic cholecystectomy. Methods Patients were randomized to receive 10 mg melatonin or placebo during surgery. Blood samples for analysis of malondialdehyde (MDA), ascorbic acid (AA), total ascorbic acid (TAA) dehydroascorbic acid (DHA) and C-reactive protein (CRP) were collected pre-operatively and at 5 min, 6 h and 24 h after operation. Results Twenty patients received melatonin and 21 patients received placebo during surgery. No significant differences were observed between the groups in the oxidative stress variables MDA, TAA, AA and DHA or in the inflammatory variable CRP (repeated-measures ANOVA, P > 0.05 for all variables). Conclusions Administration of 10 mg melatonin did not reduce variables of oxidative stress in patients undergoing elective laparoscopic cholecystectomy

Original language	English
Journal	Acta Anaesthesiologica Scandinavica
Volume	54
Issue number	9
Pages (from-to)	1121-1127
Number of pages	7
ISSN	0001-5172
DOIs	https://doi.org/10.1111/j.1399-6576.2010.02294.x
Publication status	Published - Oct 2010

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@article{09fd3fd769844a61b06331b5efa0eabd,

title = "No effect of melatonin on oxidative stress after laparoscopic cholecystectomy: a randomized placebo-controlled trial",

abstract = "Background Melatonin, an endogenous circadian regulator, also has antioxidant and anti-inflammatory properties. The aim of this study was to evaluate the antioxidative effect of melatonin in patients undergoing laparoscopic cholecystectomy. Methods Patients were randomized to receive 10 mg melatonin or placebo during surgery. Blood samples for analysis of malondialdehyde (MDA), ascorbic acid (AA), total ascorbic acid (TAA) dehydroascorbic acid (DHA) and C-reactive protein (CRP) were collected pre-operatively and at 5 min, 6 h and 24 h after operation. Results Twenty patients received melatonin and 21 patients received placebo during surgery. No significant differences were observed between the groups in the oxidative stress variables MDA, TAA, AA and DHA or in the inflammatory variable CRP (repeated-measures ANOVA, P > 0.05 for all variables). Conclusions Administration of 10 mg melatonin did not reduce variables of oxidative stress in patients undergoing elective laparoscopic cholecystectomy",

author = "B. Kucukakin and M. Klein and Jens Lykkesfeldt and R.J. Reiter and J. Rosenberg and Ismayil G{\"o}gen{\"u}r",

year = "2010",

month = oct,

doi = "10.1111/j.1399-6576.2010.02294.x",

language = "English",

volume = "54",

pages = "1121--1127",

journal = "Acta Anaesthesiologica Scandinavica",

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TY - JOUR

T1 - No effect of melatonin on oxidative stress after laparoscopic cholecystectomy: a randomized placebo-controlled trial

AU - Kucukakin, B.

AU - Klein, M.

AU - Lykkesfeldt, Jens

AU - Reiter, R.J.

AU - Rosenberg, J.

AU - Gögenür, Ismayil

PY - 2010/10

Y1 - 2010/10

N2 - Background Melatonin, an endogenous circadian regulator, also has antioxidant and anti-inflammatory properties. The aim of this study was to evaluate the antioxidative effect of melatonin in patients undergoing laparoscopic cholecystectomy. Methods Patients were randomized to receive 10 mg melatonin or placebo during surgery. Blood samples for analysis of malondialdehyde (MDA), ascorbic acid (AA), total ascorbic acid (TAA) dehydroascorbic acid (DHA) and C-reactive protein (CRP) were collected pre-operatively and at 5 min, 6 h and 24 h after operation. Results Twenty patients received melatonin and 21 patients received placebo during surgery. No significant differences were observed between the groups in the oxidative stress variables MDA, TAA, AA and DHA or in the inflammatory variable CRP (repeated-measures ANOVA, P > 0.05 for all variables). Conclusions Administration of 10 mg melatonin did not reduce variables of oxidative stress in patients undergoing elective laparoscopic cholecystectomy

AB - Background Melatonin, an endogenous circadian regulator, also has antioxidant and anti-inflammatory properties. The aim of this study was to evaluate the antioxidative effect of melatonin in patients undergoing laparoscopic cholecystectomy. Methods Patients were randomized to receive 10 mg melatonin or placebo during surgery. Blood samples for analysis of malondialdehyde (MDA), ascorbic acid (AA), total ascorbic acid (TAA) dehydroascorbic acid (DHA) and C-reactive protein (CRP) were collected pre-operatively and at 5 min, 6 h and 24 h after operation. Results Twenty patients received melatonin and 21 patients received placebo during surgery. No significant differences were observed between the groups in the oxidative stress variables MDA, TAA, AA and DHA or in the inflammatory variable CRP (repeated-measures ANOVA, P > 0.05 for all variables). Conclusions Administration of 10 mg melatonin did not reduce variables of oxidative stress in patients undergoing elective laparoscopic cholecystectomy

U2 - 10.1111/j.1399-6576.2010.02294.x

DO - 10.1111/j.1399-6576.2010.02294.x

M3 - Journal article

SN - 0001-5172

VL - 54

SP - 1121

EP - 1127

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

IS - 9

ER -