No association between striatal dopamine transporter binding and body mass index: A multi-center European study in healthy volunteers

Elsmarieke van de Giessen; Swen Hesse; Matthan W A Caan; Franziska Zientek; John C Dickson; Livia Tossici-Bolt; Terez Sera; Susanne Asenbaum; Renaud Guignard; Umit O Akdemir; Karen Birgitte Moos Knudsen; Flavio Nobili; Marco Pagani; Thierry Vander Borght; Koen Van Laere; Andrea Varrone; Klaus Tatsch; Jan Booij; Osama Sabri

doi:10.1016/j.neuroimage.2012.09.011

No association between striatal dopamine transporter binding and body mass index: A multi-center European study in healthy volunteers

Elsmarieke van de Giessen, Swen Hesse, Matthan W A Caan, Franziska Zientek, John C Dickson, Livia Tossici-Bolt, Terez Sera, Susanne Asenbaum, Renaud Guignard, Umit O Akdemir, Karen Birgitte Moos Knudsen, Flavio Nobili, Marco Pagani, Thierry Vander Borght, Koen Van Laere, Andrea Varrone, Klaus Tatsch, Jan Booij, Osama Sabri

Department of Clinical Medicine

35 Citations (Scopus)

Abstract

Introduction: Dopamine is one among several neurotransmitters that regulate food intake and overeating. Thus, it has been linked to the pathophysiology of obesity and high body mass index (BMI). Striatal dopamine D₂ receptor availability is lower in obesity and there are indications that striatal dopamine transporter (DAT) availability is also decreased. In this study, we tested whether BMI and striatal DAT availability are associated. Methods: The study included 123 healthy individuals from a large European multi-center database. They had a BMI range of 18.2-41.1kg/m² and were scanned using [¹²³I]FP-CIT SPECT imaging. Scans were analyzed with both region-of-interest and voxel-based analysis to determine the binding potential for DAT availability in the caudate nucleus and putamen. A direct relation between BMI and DAT availability was assessed and groups with high and low BMI were compared for DAT availability. Results: No association between BMI and striatal DAT availability was found. Conclusion: The lack of an association between BMI and striatal DAT availability suggests that the regulation of striatal synaptic dopamine levels by DAT plays no or a limited role in the pathophysiology of overweight and obesity.

Original language	English
Journal	NeuroImage
Volume	64
Pages (from-to)	61-7
Number of pages	7
ISSN	1053-8119
DOIs	https://doi.org/10.1016/j.neuroimage.2012.09.011
Publication status	Published - 1 Jan 2013

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van de Giessen, E., Hesse, S., Caan, M. W. A., Zientek, F., Dickson, J. C., Tossici-Bolt, L., Sera, T., Asenbaum, S., Guignard, R., Akdemir, U. O., Knudsen, K. B. M., Nobili, F., Pagani, M., Vander Borght, T., Van Laere, K., Varrone, A., Tatsch, K., Booij, J., & Sabri, O. (2013). No association between striatal dopamine transporter binding and body mass index: A multi-center European study in healthy volunteers. NeuroImage, 64, 61-7. https://doi.org/10.1016/j.neuroimage.2012.09.011

van de Giessen, E, Hesse, S, Caan, MWA, Zientek, F, Dickson, JC, Tossici-Bolt, L, Sera, T, Asenbaum, S, Guignard, R, Akdemir, UO, Knudsen, KBM, Nobili, F, Pagani, M, Vander Borght, T, Van Laere, K, Varrone, A, Tatsch, K, Booij, J & Sabri, O 2013, 'No association between striatal dopamine transporter binding and body mass index: A multi-center European study in healthy volunteers', NeuroImage, vol. 64, pp. 61-7. https://doi.org/10.1016/j.neuroimage.2012.09.011

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title = "No association between striatal dopamine transporter binding and body mass index: A multi-center European study in healthy volunteers",

abstract = "Introduction: Dopamine is one among several neurotransmitters that regulate food intake and overeating. Thus, it has been linked to the pathophysiology of obesity and high body mass index (BMI). Striatal dopamine D2 receptor availability is lower in obesity and there are indications that striatal dopamine transporter (DAT) availability is also decreased. In this study, we tested whether BMI and striatal DAT availability are associated. Methods: The study included 123 healthy individuals from a large European multi-center database. They had a BMI range of 18.2-41.1kg/m2 and were scanned using [123I]FP-CIT SPECT imaging. Scans were analyzed with both region-of-interest and voxel-based analysis to determine the binding potential for DAT availability in the caudate nucleus and putamen. A direct relation between BMI and DAT availability was assessed and groups with high and low BMI were compared for DAT availability. Results: No association between BMI and striatal DAT availability was found. Conclusion: The lack of an association between BMI and striatal DAT availability suggests that the regulation of striatal synaptic dopamine levels by DAT plays no or a limited role in the pathophysiology of overweight and obesity.",

author = "{van de Giessen}, Elsmarieke and Swen Hesse and Caan, {Matthan W A} and Franziska Zientek and Dickson, {John C} and Livia Tossici-Bolt and Terez Sera and Susanne Asenbaum and Renaud Guignard and Akdemir, {Umit O} and Knudsen, {Karen Birgitte Moos} and Flavio Nobili and Marco Pagani and {Vander Borght}, Thierry and {Van Laere}, Koen and Andrea Varrone and Klaus Tatsch and Jan Booij and Osama Sabri",

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doi = "10.1016/j.neuroimage.2012.09.011",

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T1 - No association between striatal dopamine transporter binding and body mass index

T2 - A multi-center European study in healthy volunteers

AU - van de Giessen, Elsmarieke

AU - Hesse, Swen

AU - Caan, Matthan W A

AU - Zientek, Franziska

AU - Dickson, John C

AU - Tossici-Bolt, Livia

AU - Sera, Terez

AU - Asenbaum, Susanne

AU - Guignard, Renaud

AU - Akdemir, Umit O

AU - Knudsen, Karen Birgitte Moos

AU - Nobili, Flavio

AU - Pagani, Marco

AU - Vander Borght, Thierry

AU - Van Laere, Koen

AU - Varrone, Andrea

AU - Tatsch, Klaus

AU - Booij, Jan

AU - Sabri, Osama

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Introduction: Dopamine is one among several neurotransmitters that regulate food intake and overeating. Thus, it has been linked to the pathophysiology of obesity and high body mass index (BMI). Striatal dopamine D2 receptor availability is lower in obesity and there are indications that striatal dopamine transporter (DAT) availability is also decreased. In this study, we tested whether BMI and striatal DAT availability are associated. Methods: The study included 123 healthy individuals from a large European multi-center database. They had a BMI range of 18.2-41.1kg/m2 and were scanned using [123I]FP-CIT SPECT imaging. Scans were analyzed with both region-of-interest and voxel-based analysis to determine the binding potential for DAT availability in the caudate nucleus and putamen. A direct relation between BMI and DAT availability was assessed and groups with high and low BMI were compared for DAT availability. Results: No association between BMI and striatal DAT availability was found. Conclusion: The lack of an association between BMI and striatal DAT availability suggests that the regulation of striatal synaptic dopamine levels by DAT plays no or a limited role in the pathophysiology of overweight and obesity.

AB - Introduction: Dopamine is one among several neurotransmitters that regulate food intake and overeating. Thus, it has been linked to the pathophysiology of obesity and high body mass index (BMI). Striatal dopamine D2 receptor availability is lower in obesity and there are indications that striatal dopamine transporter (DAT) availability is also decreased. In this study, we tested whether BMI and striatal DAT availability are associated. Methods: The study included 123 healthy individuals from a large European multi-center database. They had a BMI range of 18.2-41.1kg/m2 and were scanned using [123I]FP-CIT SPECT imaging. Scans were analyzed with both region-of-interest and voxel-based analysis to determine the binding potential for DAT availability in the caudate nucleus and putamen. A direct relation between BMI and DAT availability was assessed and groups with high and low BMI were compared for DAT availability. Results: No association between BMI and striatal DAT availability was found. Conclusion: The lack of an association between BMI and striatal DAT availability suggests that the regulation of striatal synaptic dopamine levels by DAT plays no or a limited role in the pathophysiology of overweight and obesity.

U2 - 10.1016/j.neuroimage.2012.09.011

DO - 10.1016/j.neuroimage.2012.09.011

M3 - Journal article

C2 - 22982354

SN - 1053-8119

VL - 64

SP - 61

EP - 67

JO - NeuroImage

JF - NeuroImage

ER -

No association between striatal dopamine transporter binding and body mass index: A multi-center European study in healthy volunteers

Abstract

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