No association between iron status and self-reported health-related quality of life in 16,375 Danish blood donors: results from the Danish Blood Donor Study

TY - JOUR

T1 - No association between iron status and self-reported health-related quality of life in 16,375 Danish blood donors

T2 - results from the Danish Blood Donor Study

AU - Rigas, Andreas S

AU - Pedersen, Ole B

AU - Sørensen, Cecilie J

AU - Sørensen, Erik

AU - Kotze, Sebastian Ranzi

AU - Petersen, Mikkel S

AU - Thørner, Lise Wegner

AU - Hjalgrim, Henrik

AU - Erikstrup, Christian

AU - Ullum, Henrik

N1 - © 2015 AABB.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - BACKGROUND Health-related quality of life (HRQL) represents people's subjective assessment of their mental and physical well-being. HRQL is highly predictive of future health. The effect of iron deficiency without anemia induced by blood donation on HRQL is presently unknown. The aim was to explore the relationship between iron status and self-reported mental component score (MCS; SF-12) and physical component score (PCS; SF-12) in Danish blood donors. STUDY DESIGN AND METHODS Complete relevant data, including the 12-item short-form health survey (SF-12), plasma ferritin levels, age, body mass index, smoking status, C-reactive protein levels, number of donations in the previous 3 years, and PCS and MCS, were available for 8692 men and 7683 women enrolled from March 1, 2010, to December 31, 2010. Multivariable linear and logistic (cutoff at the 10th percentile) regression analyses were used to assess the relationship between iron deficiency (ferritin<15 ng/mL) and MCS and PCS, respectively. Analyses were performed separately for men and women. RESULTS There was no significant relationship between iron deficiency and self-reported mental or physical health. CONCLUSION This study found no association between iron stores and self-reported HRQL among Danish blood donors.

AB - BACKGROUND Health-related quality of life (HRQL) represents people's subjective assessment of their mental and physical well-being. HRQL is highly predictive of future health. The effect of iron deficiency without anemia induced by blood donation on HRQL is presently unknown. The aim was to explore the relationship between iron status and self-reported mental component score (MCS; SF-12) and physical component score (PCS; SF-12) in Danish blood donors. STUDY DESIGN AND METHODS Complete relevant data, including the 12-item short-form health survey (SF-12), plasma ferritin levels, age, body mass index, smoking status, C-reactive protein levels, number of donations in the previous 3 years, and PCS and MCS, were available for 8692 men and 7683 women enrolled from March 1, 2010, to December 31, 2010. Multivariable linear and logistic (cutoff at the 10th percentile) regression analyses were used to assess the relationship between iron deficiency (ferritin<15 ng/mL) and MCS and PCS, respectively. Analyses were performed separately for men and women. RESULTS There was no significant relationship between iron deficiency and self-reported mental or physical health. CONCLUSION This study found no association between iron stores and self-reported HRQL among Danish blood donors.

KW - Adolescent

KW - Adult

KW - Age Factors

KW - Aged

KW - Blood Donors

KW - Body Mass Index

KW - C-Reactive Protein

KW - Cohort Studies

KW - Denmark

KW - Female

KW - Ferritins

KW - Humans

KW - Iron

KW - Male

KW - Mental Health

KW - Middle Aged

KW - Quality of Life

KW - Self Report

KW - Clinical Trial

KW - Journal Article

KW - Multicenter Study

KW - Research Support, Non-U.S. Gov't

U2 - 10.1111/trf.13085

DO - 10.1111/trf.13085

M3 - Journal article

C2 - 25851623

SN - 0041-1132

VL - 55

SP - 1752

EP - 1756

JO - Transfusion

JF - Transfusion

IS - 7

ER -