New insights into the formation and resolution of ultra-fine anaphase bridges

TY - JOUR

T1 - New insights into the formation and resolution of ultra-fine anaphase bridges

AU - Chan, Kok Lung

AU - Hickson, Ian D

N1 - Copyright © 2011 Elsevier Ltd. All rights reserved.

PY - 2011/10

Y1 - 2011/10

N2 - Recent data indicate an unexpected requirement for proteins that were hitherto considered to be dedicated to DNA repair to facilitate the faithful disjunction of sister chromatids in anaphase. These include the Bloom's syndrome gene product, BLM and its partners, as well as a number of proteins that are important for preventing Fanconi anemia (FA) in man. As part of an analysis of the roles of these proteins in mitosis, we identified a novel class of anaphase bridge structure, called an ultra-fine anaphase bridge (UFB). These UFBs are also defined by the presence of a SNF2 family protein called PICH. In this review, we will discuss the possible sources of UFBs, and how the BLM, PICH and FA proteins might serve to process these structures in order to maintain genome stability.

AB - Recent data indicate an unexpected requirement for proteins that were hitherto considered to be dedicated to DNA repair to facilitate the faithful disjunction of sister chromatids in anaphase. These include the Bloom's syndrome gene product, BLM and its partners, as well as a number of proteins that are important for preventing Fanconi anemia (FA) in man. As part of an analysis of the roles of these proteins in mitosis, we identified a novel class of anaphase bridge structure, called an ultra-fine anaphase bridge (UFB). These UFBs are also defined by the presence of a SNF2 family protein called PICH. In this review, we will discuss the possible sources of UFBs, and how the BLM, PICH and FA proteins might serve to process these structures in order to maintain genome stability.

KW - Anaphase

KW - Humans

KW - Models, Genetic

U2 - 10.1016/j.semcdb.2011.07.001

DO - 10.1016/j.semcdb.2011.07.001

M3 - Review

C2 - 21782962

SN - 1084-9521

VL - 22

SP - 906

EP - 912

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

IS - 8

ER -