New insights into the diagnosis of hidradenitis suppurativa: Clinical presentations and phenotypes

TY - JOUR

T1 - New insights into the diagnosis of hidradenitis suppurativa

T2 - Clinical presentations and phenotypes

AU - van der Zee, Hessel H

AU - Jemec, Gregor B E

N1 - Copyright © 2015 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

PY - 2015/11

Y1 - 2015/11

N2 - Current classifications for hidradenitis suppurativa (HS), such as the Hurley staging system, are not very specific. The absence of rigorous classifications is incongruous with the clinical variability of the condition. There is no pathognomonic sign for HS that leads to a diagnosis that is unquestionable. Consequently, diagnosis is made largely through clinical presentation of the condition. The use of several validated tools assists in confirming the diagnosis and the severity of the disease. In future investigations, the identification of phenotypes and clinical subtypes--taking into account genetic variants--will serve to identify subpopulations of patients who are responsive to particular therapies, thereby improving the overall therapeutic picture for patients with HS. There is a potential for personalized, tailored delivery of therapy in the HS setting.

AB - Current classifications for hidradenitis suppurativa (HS), such as the Hurley staging system, are not very specific. The absence of rigorous classifications is incongruous with the clinical variability of the condition. There is no pathognomonic sign for HS that leads to a diagnosis that is unquestionable. Consequently, diagnosis is made largely through clinical presentation of the condition. The use of several validated tools assists in confirming the diagnosis and the severity of the disease. In future investigations, the identification of phenotypes and clinical subtypes--taking into account genetic variants--will serve to identify subpopulations of patients who are responsive to particular therapies, thereby improving the overall therapeutic picture for patients with HS. There is a potential for personalized, tailored delivery of therapy in the HS setting.

KW - Adult

KW - Anti-Infective Agents

KW - Anti-Inflammatory Agents

KW - Biopsy, Needle

KW - Female

KW - Genetic Predisposition to Disease

KW - Hidradenitis Suppurativa

KW - Humans

KW - Immunohistochemistry

KW - Male

KW - Phenotype

KW - Sensitivity and Specificity

KW - Severity of Illness Index

KW - Treatment Outcome

KW - Young Adult

KW - Comparative Study

KW - Journal Article

KW - Review

U2 - 10.1016/j.jaad.2015.07.047

DO - 10.1016/j.jaad.2015.07.047

M3 - Journal article

C2 - 26470610

SN - 0190-9622

VL - 73

SP - S23-6

JO - American Academy of Dermatology. Journal

JF - American Academy of Dermatology. Journal

IS - 5 Suppl 1

ER -