Neuropeptide Y and its involvement in chronic pain

Marta Diaz-delCastillo; David P D Woldbye; Anne Marie Heegaard

doi:10.1016/j.neuroscience.2017.08.050

Neuropeptide Y and its involvement in chronic pain

Marta Diaz-delCastillo, David P D Woldbye, Anne Marie Heegaard

Neuropharm and Genetics

19 Citations (Scopus)

Abstract

Chronic pain is a serious condition that significantly impairs the quality of life, affecting an estimate of 1.5 billion people worldwide. Despite the physiological, emotional and financial burden of chronic pain, there is still a lack of efficient treatments. Neuropeptide Y (NPY) is a highly conserved endogenous peptide in the central and peripheral nervous systems of all mammals, which has been implicated in both pro- and antinociceptive effects. NPY is expressed in the superficial laminae of the dorsal horn of the spinal cord, where it appears to mediate its antinociceptive actions via the Y1 and Y2 receptors. Intrathecal administration of NPY in animal models of neuropathic, inflammatory or postoperative pain has been shown to cause analgesia, even though its exact mechanisms are still unclear. It remains to be seen whether these promising central antinociceptive effects of NPY can be transferred into a future treatment for chronic pain.

Original language	English
Journal	Neuroscience
Volume	387
Pages (from-to)	162-169
Number of pages	8
ISSN	0306-4522
DOIs	https://doi.org/10.1016/j.neuroscience.2017.08.050
Publication status	Published - 1 Sept 2018

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10.1016/j.neuroscience.2017.08.050

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abstract = "Chronic pain is a serious condition that significantly impairs the quality of life, affecting an estimate of 1.5 billion people worldwide. Despite the physiological, emotional and financial burden of chronic pain, there is still a lack of efficient treatments. Neuropeptide Y (NPY) is a highly conserved endogenous peptide in the central and peripheral nervous systems of all mammals, which has been implicated in both pro- and antinociceptive effects. NPY is expressed in the superficial laminae of the dorsal horn of the spinal cord, where it appears to mediate its antinociceptive actions via the Y1 and Y2 receptors. Intrathecal administration of NPY in animal models of neuropathic, inflammatory or postoperative pain has been shown to cause analgesia, even though its exact mechanisms are still unclear. It remains to be seen whether these promising central antinociceptive effects of NPY can be transferred into a future treatment for chronic pain.",

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AU - Woldbye, David P D

AU - Heegaard, Anne Marie

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Neuropeptide Y and its involvement in chronic pain

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