Neuroendocrine control of Drosophila larval light preference

Naoki Yamanaka; Nuria M. Romero; Francisco A. Martin; Kim Furbo Rewitz; Mu Sun; Michael B. O´Connor; Pierre Léopold

doi:10.1126/science.1241210

Neuroendocrine control of Drosophila larval light preference

Naoki Yamanaka, Nuria M. Romero, Francisco A. Martin, Kim Furbo Rewitz, Mu Sun, Michael B. O´Connor, Pierre Léopold

Cell and Neurobiology

65 Citations (Scopus)

Abstract

Animal development is coupled with innate behaviors that maximize chances of survival. Here, we show that the prothoracicotropic hormone (PTTH), a neuropeptide that controls the developmental transition from juvenile stage to sexual maturation, also regulates light avoidance in Drosophila melanogaster larvae. PTTH, through its receptor Torso, acts on two light sensors???the Bolwig???s organ and the peripheral class IV dendritic arborization neurons???to regulate light avoidance. We found that PTTH concomitantly promotes steroidogenesis and light avoidance at the end of larval stage, driving animals toward a darker environment to initiate the immobile maturation phase. Thus, PTTH controls the decisions of when and where animals undergo metamorphosis, optimizing conditions for adult development.

Original language	English
Journal	Science
Volume	341
Issue number	6150
Pages (from-to)	1113-1116
Number of pages	4
ISSN	0036-8075
DOIs	https://doi.org/10.1126/science.1241210
Publication status	Published - 6 Sept 2013

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10.1126/science.1241210

http://www.sciencemag.org/content/341/6150/1113.abstract

Cite this

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title = "Neuroendocrine control of Drosophila larval light preference",

abstract = "Animal development is coupled with innate behaviors that maximize chances of survival. Here, we show that the prothoracicotropic hormone (PTTH), a neuropeptide that controls the developmental transition from juvenile stage to sexual maturation, also regulates light avoidance in Drosophila melanogaster larvae. PTTH, through its receptor Torso, acts on two light sensors???the Bolwig???s organ and the peripheral class IV dendritic arborization neurons???to regulate light avoidance. We found that PTTH concomitantly promotes steroidogenesis and light avoidance at the end of larval stage, driving animals toward a darker environment to initiate the immobile maturation phase. Thus, PTTH controls the decisions of when and where animals undergo metamorphosis, optimizing conditions for adult development.",

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T1 - Neuroendocrine control of Drosophila larval light preference

AU - Yamanaka, Naoki

AU - Romero, Nuria M.

AU - Martin, Francisco A.

AU - Rewitz, Kim Furbo

AU - Sun, Mu

AU - O´Connor, Michael B.

AU - Léopold, Pierre

PY - 2013/9/6

Y1 - 2013/9/6

N2 - Animal development is coupled with innate behaviors that maximize chances of survival. Here, we show that the prothoracicotropic hormone (PTTH), a neuropeptide that controls the developmental transition from juvenile stage to sexual maturation, also regulates light avoidance in Drosophila melanogaster larvae. PTTH, through its receptor Torso, acts on two light sensors???the Bolwig???s organ and the peripheral class IV dendritic arborization neurons???to regulate light avoidance. We found that PTTH concomitantly promotes steroidogenesis and light avoidance at the end of larval stage, driving animals toward a darker environment to initiate the immobile maturation phase. Thus, PTTH controls the decisions of when and where animals undergo metamorphosis, optimizing conditions for adult development.

AB - Animal development is coupled with innate behaviors that maximize chances of survival. Here, we show that the prothoracicotropic hormone (PTTH), a neuropeptide that controls the developmental transition from juvenile stage to sexual maturation, also regulates light avoidance in Drosophila melanogaster larvae. PTTH, through its receptor Torso, acts on two light sensors???the Bolwig???s organ and the peripheral class IV dendritic arborization neurons???to regulate light avoidance. We found that PTTH concomitantly promotes steroidogenesis and light avoidance at the end of larval stage, driving animals toward a darker environment to initiate the immobile maturation phase. Thus, PTTH controls the decisions of when and where animals undergo metamorphosis, optimizing conditions for adult development.

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DO - 10.1126/science.1241210

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