TY - JOUR
T1 - Neurocognitive development in first episode psychosis 5 years follow-up
T2 - associations between illness severity and cognitive course
AU - Barder, Helene Eidsmo
AU - Sundet, Kjetil
AU - Rund, Bjørn Rishovd
AU - Evensen, Julie
AU - Haahr, Ulrik
AU - Ten Velden Hegelstad, Wenche
AU - Joa, Inge
AU - Johannessen, Jan Olav
AU - Langeveld, Hans
AU - Larsen, T K
AU - Melle, Ingrid
AU - Opjordsmoen, Stein
AU - Røssberg, Jan Ivar
AU - Simonsen, Erik
AU - Vaglum, Per
AU - McGlashan, Thomas
AU - Friis, Svein
N1 - Copyright © 2013 Elsevier B.V. All rights reserved.
PY - 2013/9
Y1 - 2013/9
N2 - Cognitive deficits are documented in first-episode psychosis (FEP), but the continuing course is not fully understood. The present study examines the longitudinal development of neurocognitive function in a five year follow-up of FEP-patients, focusing on the relation to illness severity, as measured by relapses and diagnostic subgroups. The study is an extension of previous findings from the TIPS-project, reporting stability over the first two years. Sixty-two FEP patients (53% male, age 28 ± 9 years) were neuropsychologically examined at baseline and at 1, 2, and 5 year follow-ups. The test battery was divided into five indices; Verbal Learning, Executive Function, Impulsivity, Motor Speed, and Working Memory. To investigate the effect of illness severity, the sample was divided in groups based on number of relapses, and diagnostic subgroups, respectively. Impulsivity and Working Memory improved significantly in the first two years, followed by no change over the next three years. Motor Speed decreased significantly from 2 to 5 years. Number of relapses was significantly related to Verbal Learning and Working Memory, showing a small decrease and less improvement, respectively, in patients with two or more episodes. No significant association was found with diagnostic group. Neurocognitive stability as well as change was found in a sample of FEP-patients examined repeatedly over 5 years. Of potential greater importance for understanding how psychotic illnesses progress, is the finding of significant associations between neurocognition and number of relapses but not diagnostic group, indicating that neurocognition is more related to recurring psychotic episodes than to the descriptive diagnosis per se.
AB - Cognitive deficits are documented in first-episode psychosis (FEP), but the continuing course is not fully understood. The present study examines the longitudinal development of neurocognitive function in a five year follow-up of FEP-patients, focusing on the relation to illness severity, as measured by relapses and diagnostic subgroups. The study is an extension of previous findings from the TIPS-project, reporting stability over the first two years. Sixty-two FEP patients (53% male, age 28 ± 9 years) were neuropsychologically examined at baseline and at 1, 2, and 5 year follow-ups. The test battery was divided into five indices; Verbal Learning, Executive Function, Impulsivity, Motor Speed, and Working Memory. To investigate the effect of illness severity, the sample was divided in groups based on number of relapses, and diagnostic subgroups, respectively. Impulsivity and Working Memory improved significantly in the first two years, followed by no change over the next three years. Motor Speed decreased significantly from 2 to 5 years. Number of relapses was significantly related to Verbal Learning and Working Memory, showing a small decrease and less improvement, respectively, in patients with two or more episodes. No significant association was found with diagnostic group. Neurocognitive stability as well as change was found in a sample of FEP-patients examined repeatedly over 5 years. Of potential greater importance for understanding how psychotic illnesses progress, is the finding of significant associations between neurocognition and number of relapses but not diagnostic group, indicating that neurocognition is more related to recurring psychotic episodes than to the descriptive diagnosis per se.
KW - Adolescent
KW - Adult
KW - Aged
KW - Attitude
KW - Cognition Disorders
KW - Executive Function
KW - Female
KW - Humans
KW - Longitudinal Studies
KW - Male
KW - Memory, Short-Term
KW - Middle Aged
KW - Motor Activity
KW - Multivariate Analysis
KW - Neuropsychological Tests
KW - Psychotic Disorders
KW - Severity of Illness Index
KW - Time Factors
KW - Verbal Learning
KW - Young Adult
U2 - 10.1016/j.schres.2013.06.016
DO - 10.1016/j.schres.2013.06.016
M3 - Journal article
C2 - 23810121
SN - 0920-9964
VL - 149
SP - 63
EP - 69
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1-3
ER -