Network biology concepts in complex disease comorbidities

TY - JOUR

T1 - Network biology concepts in complex disease comorbidities

AU - Hu, Jessica Xin

AU - Thomas, Cecilia Engel

AU - Brunak, Søren

PY - 2016/10/1

Y1 - 2016/10/1

N2 - The co-occurrence of diseases can inform the underlying network biology of shared and multifunctional genes and pathways. In addition, comorbidities help to elucidate the effects of external exposures, such as diet, lifestyle and patient care. With worldwide health transaction data now often being collected electronically, disease co-occurrences are starting to be quantitatively characterized. Linking network dynamics to the real-life, non-ideal patient in whom diseases co-occur and interact provides a valuable basis for generating hypotheses on molecular disease mechanisms, and provides knowledge that can facilitate drug repurposing and the development of targeted therapeutic strategies.

AB - The co-occurrence of diseases can inform the underlying network biology of shared and multifunctional genes and pathways. In addition, comorbidities help to elucidate the effects of external exposures, such as diet, lifestyle and patient care. With worldwide health transaction data now often being collected electronically, disease co-occurrences are starting to be quantitatively characterized. Linking network dynamics to the real-life, non-ideal patient in whom diseases co-occur and interact provides a valuable basis for generating hypotheses on molecular disease mechanisms, and provides knowledge that can facilitate drug repurposing and the development of targeted therapeutic strategies.

U2 - 10.1038/nrg.2016.87

DO - 10.1038/nrg.2016.87

M3 - Review

C2 - 27498692

SN - 1471-0056

VL - 17

SP - 615

EP - 629

JO - Nature Reviews. Genetics

JF - Nature Reviews. Genetics

ER -