Network-based drugs and biomarkers

Janine Terra Erler; Rune Linding

doi:10.1002/path.2646

Network-based drugs and biomarkers

57 Citations (Scopus)

Abstract

The structure and dynamics of protein signalling networks governs cell decision processes and the formation of tissue boundaries. Complex diseases such as cancer and diabetes are diseases of such networks. Therefore approaches that can give insight into how these networks change during disease progression are crucial for better understanding, detection and intervention. The era of network medicine has begun; however, there are fundamental principles associated with molecular networks that are essential to consider for this field to succeed. Here, we introduce network biology and some of its associated technologies. We then focus on the multivariate nature of cellular networks and how this has implications for biomarker and drug discovery using cancer metastasis as an example.

Original language	English
Journal	Journal of Pathology
Volume	220
Issue number	2
Pages (from-to)	290-6
Number of pages	7
ISSN	0022-3417
DOIs	https://doi.org/10.1002/path.2646
Publication status	Published - Jan 2010
Externally published	Yes

Keywords

Antineoplastic Agents
Biological Markers
Drug Discovery
Humans
Models, Biological
Neoplasm Metastasis
Signal Transduction
Systems Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/path.2646

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/path.2646

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KW - Biological Markers

KW - Drug Discovery

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KW - Models, Biological

KW - Neoplasm Metastasis

KW - Signal Transduction

KW - Systems Biology

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Network-based drugs and biomarkers

Abstract

Keywords

UN SDGs

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