Neonatal Cytokine Profile in the Airway Mucosal Lining Fluid is skewed by Maternal Atopy

Nilofar Vahman Følsgaard; Bo Lund Krogsgaard Chawes; Morten Arendt Rasmussen; Anne Louise Bischoff; Charlotte G. Carson; Jakob Stokholm; Louise Lindkvist Pedersen; Trevor T. Hansel; Klaus Bønnelykke; Susanne Brix; Hans Bisgaard

doi:10.1164/rccm.201108-1471oc

Neonatal Cytokine Profile in the Airway Mucosal Lining Fluid is skewed by Maternal Atopy

Nilofar Vahman Følsgaard, Bo Lund Krogsgaard Chawes, Morten Arendt Rasmussen, Anne Louise Bischoff, Charlotte G. Carson, Jakob Stokholm, Louise Lindkvist Pedersen, Trevor T. Hansel, Klaus Bønnelykke, Susanne Brix, Hans Bisgaard

Department of Clinical Medicine

45 Citations (Scopus)

Abstract

Rationale: Heredity from mother or father may impact differently in complexdiseases, suchasatopy.Maternal atopy isastronger risk factor than paternal atopy for the development of atopy in the offspring.We hypothesized that mother's and father's atopy would have a differential imprinting on the cytokines and chemokines in the upper airway mucosal lining fluid of healthy neonates. Objectives: To study parental atopic imprinting on the cytokines and chemokines in the upper airway mucosal lining fluid of healthy neonates. Methods: Eighteen cytokines and chemokineswere quantified in nasal mucosal lining fluid in 309 neonates from the novel unselected Copenhagen Prospective Study on Asthma in Childhood (COPSAC) birth cohort. Measurements and Main Results:Maternal, but not paternal, atopic status (asthma, hay fever, or eczema with or without sensitization) was associated with general down-regulation of all 18 mediators assessed by principal component analysis (overall P = 0.015). Conclusions:Maternalatopy,butnotpaternal atopy,showedastrong linkage with a suppressed mucosal cytokine and chemokine signature in asymptomatic neonates, suggesting imprinting by the maternal milieu in utero or perinatal life.

Original language	English
Journal	American Journal of Respiratory and Critical Care Medicine
Volume	185
Issue number	3
Pages (from-to)	275-280
Number of pages	6
ISSN	1073-449X
DOIs	https://doi.org/10.1164/rccm.201108-1471oc
Publication status	Published - 1 Feb 2012

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Neonatal cytokine profile in the airway mucosal liningFinal published version, 233 KB

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Følsgaard, N. V., Chawes, B. L. K., Rasmussen, M. A., Bischoff, A. L., Carson, C. G., Stokholm, J., Pedersen, L. L., Hansel, T. T., Bønnelykke, K., Brix, S., & Bisgaard, H. (2012). Neonatal Cytokine Profile in the Airway Mucosal Lining Fluid is skewed by Maternal Atopy. American Journal of Respiratory and Critical Care Medicine, 185(3), 275-280. https://doi.org/10.1164/rccm.201108-1471oc

Neonatal Cytokine Profile in the Airway Mucosal Lining Fluid is skewed by Maternal Atopy. / Følsgaard, Nilofar Vahman; Chawes, Bo Lund Krogsgaard ; Rasmussen, Morten Arendt et al.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 185, No. 3, 01.02.2012, p. 275-280.

Research output: Contribution to journal › Journal article › Research › peer-review

Følsgaard, NV, Chawes, BLK , Rasmussen, MA, Bischoff, AL, Carson, CG, Stokholm, J, Pedersen, LL, Hansel, TT, Bønnelykke, K, Brix, S & Bisgaard, H 2012, 'Neonatal Cytokine Profile in the Airway Mucosal Lining Fluid is skewed by Maternal Atopy', American Journal of Respiratory and Critical Care Medicine, vol. 185, no. 3, pp. 275-280. https://doi.org/10.1164/rccm.201108-1471oc

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abstract = "Rationale: Heredity from mother or father may impact differently in complexdiseases, suchasatopy.Maternal atopy isastronger risk factor than paternal atopy for the development of atopy in the offspring.We hypothesized that mother's and father's atopy would have a differential imprinting on the cytokines and chemokines in the upper airway mucosal lining fluid of healthy neonates. Objectives: To study parental atopic imprinting on the cytokines and chemokines in the upper airway mucosal lining fluid of healthy neonates. Methods: Eighteen cytokines and chemokineswere quantified in nasal mucosal lining fluid in 309 neonates from the novel unselected Copenhagen Prospective Study on Asthma in Childhood (COPSAC) birth cohort. Measurements and Main Results:Maternal, but not paternal, atopic status (asthma, hay fever, or eczema with or without sensitization) was associated with general down-regulation of all 18 mediators assessed by principal component analysis (overall P = 0.015). Conclusions:Maternalatopy,butnotpaternal atopy,showedastrong linkage with a suppressed mucosal cytokine and chemokine signature in asymptomatic neonates, suggesting imprinting by the maternal milieu in utero or perinatal life.",

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AU - Følsgaard, Nilofar Vahman

AU - Chawes, Bo Lund Krogsgaard

AU - Rasmussen, Morten Arendt

AU - Bischoff, Anne Louise

AU - Carson, Charlotte G.

AU - Stokholm, Jakob

AU - Pedersen, Louise Lindkvist

AU - Hansel, Trevor T.

AU - Bønnelykke, Klaus

AU - Brix, Susanne

AU - Bisgaard, Hans

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N2 - Rationale: Heredity from mother or father may impact differently in complexdiseases, suchasatopy.Maternal atopy isastronger risk factor than paternal atopy for the development of atopy in the offspring.We hypothesized that mother's and father's atopy would have a differential imprinting on the cytokines and chemokines in the upper airway mucosal lining fluid of healthy neonates. Objectives: To study parental atopic imprinting on the cytokines and chemokines in the upper airway mucosal lining fluid of healthy neonates. Methods: Eighteen cytokines and chemokineswere quantified in nasal mucosal lining fluid in 309 neonates from the novel unselected Copenhagen Prospective Study on Asthma in Childhood (COPSAC) birth cohort. Measurements and Main Results:Maternal, but not paternal, atopic status (asthma, hay fever, or eczema with or without sensitization) was associated with general down-regulation of all 18 mediators assessed by principal component analysis (overall P = 0.015). Conclusions:Maternalatopy,butnotpaternal atopy,showedastrong linkage with a suppressed mucosal cytokine and chemokine signature in asymptomatic neonates, suggesting imprinting by the maternal milieu in utero or perinatal life.

AB - Rationale: Heredity from mother or father may impact differently in complexdiseases, suchasatopy.Maternal atopy isastronger risk factor than paternal atopy for the development of atopy in the offspring.We hypothesized that mother's and father's atopy would have a differential imprinting on the cytokines and chemokines in the upper airway mucosal lining fluid of healthy neonates. Objectives: To study parental atopic imprinting on the cytokines and chemokines in the upper airway mucosal lining fluid of healthy neonates. Methods: Eighteen cytokines and chemokineswere quantified in nasal mucosal lining fluid in 309 neonates from the novel unselected Copenhagen Prospective Study on Asthma in Childhood (COPSAC) birth cohort. Measurements and Main Results:Maternal, but not paternal, atopic status (asthma, hay fever, or eczema with or without sensitization) was associated with general down-regulation of all 18 mediators assessed by principal component analysis (overall P = 0.015). Conclusions:Maternalatopy,butnotpaternal atopy,showedastrong linkage with a suppressed mucosal cytokine and chemokine signature in asymptomatic neonates, suggesting imprinting by the maternal milieu in utero or perinatal life.

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Neonatal Cytokine Profile in the Airway Mucosal Lining Fluid is skewed by Maternal Atopy

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