Neo-antigen specific memory T-cell responses in healthy individuals

Morten Orebo Holmström; Hans Carl Hasselbalch; Mads Hald Andersen

doi:10.1080/2162402x.2019.1599640

Neo-antigen specific memory T-cell responses in healthy individuals

Morten Orebo Holmström^*, Hans Carl Hasselbalch, Mads Hald Andersen

^*Corresponding author for this work

Department of Clinical Medicine

1 Citation (Scopus)

Abstract

The driver mutations in exon 9 of the calreticulin protein have only been identified in patients with myeloid cancers. We recently demonstrated that healthy individuals display strong and frequent T-cell responses towards this mutation. This memory T-cell response is likely evidence of the elimination of mutated cells in healthy individuals.

Original language	English
Article number	1599640
Journal	OncoImmunology
Volume	8
Issue number	7
Number of pages	2
ISSN	2162-4011
DOIs	https://doi.org/10.1080/2162402x.2019.1599640
Publication status	Published - 2019

Keywords

calreticulin
cancer immunoediting
hematological cancer
memory T-cells
Neoantigens

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/2162402x.2019.1599640

2162402X.2019.1599640?needAccess=trueFinal published version, 993 KB

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title = "Neo-antigen specific memory T-cell responses in healthy individuals",

abstract = "The driver mutations in exon 9 of the calreticulin protein have only been identified in patients with myeloid cancers. We recently demonstrated that healthy individuals display strong and frequent T-cell responses towards this mutation. This memory T-cell response is likely evidence of the elimination of mutated cells in healthy individuals.",

keywords = "calreticulin, cancer immunoediting, hematological cancer, memory T-cells, Neoantigens",

author = "Holmstr{\"o}m, {Morten Orebo} and Hasselbalch, {Hans Carl} and Andersen, {Mads Hald}",

year = "2019",

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T1 - Neo-antigen specific memory T-cell responses in healthy individuals

AU - Holmström, Morten Orebo

AU - Hasselbalch, Hans Carl

AU - Andersen, Mads Hald

PY - 2019

Y1 - 2019

N2 - The driver mutations in exon 9 of the calreticulin protein have only been identified in patients with myeloid cancers. We recently demonstrated that healthy individuals display strong and frequent T-cell responses towards this mutation. This memory T-cell response is likely evidence of the elimination of mutated cells in healthy individuals.

AB - The driver mutations in exon 9 of the calreticulin protein have only been identified in patients with myeloid cancers. We recently demonstrated that healthy individuals display strong and frequent T-cell responses towards this mutation. This memory T-cell response is likely evidence of the elimination of mutated cells in healthy individuals.

KW - calreticulin

KW - cancer immunoediting

KW - hematological cancer

KW - memory T-cells

KW - Neoantigens

U2 - 10.1080/2162402x.2019.1599640

DO - 10.1080/2162402x.2019.1599640

M3 - Letter

C2 - 31143522

AN - SCOPUS:85064717366

SN - 2162-4011

VL - 8

JO - OncoImmunology

JF - OncoImmunology

IS - 7

M1 - 1599640

ER -

Neo-antigen specific memory T-cell responses in healthy individuals

Abstract

Keywords

UN SDGs

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