Neisseria meningitidis. Lipopolysakkariders patofysiologiske rolle ved meningokoksygdom og septisk shock

Mie Østergaard Pedersen; Dan Sonne Pedersen; Michael Pedersen; Milena Penkowa

Neisseria meningitidis. Lipopolysakkariders patofysiologiske rolle ved meningokoksygdom og septisk shock

Translated title of the contribution: Neisseria meningitidis. The pathophysiological role of lipopolysaccharides in association with meningococcal disease and septic shock

Mie Østergaard Pedersen, Dan Sonne Pedersen, Michael Pedersen, Milena Penkowa

1 Citation (Scopus)

Abstract

A major pro-inflammatory and toxic component of N. meningitidis is lipopolysaccharide (LPS). LPS contributes to severe symptoms of meningococcal disease, septic shock and severe coagulopathy, in part by increasing pro-inflammatory mechanisms and reactive oxygen species. Recent technologies have increased the likelihood of developing an anti-meningococcal immunization strategy based upon the virulence of LPS which may lead to a vaccination against this important pathogen including serogroup B disease. This review summarizes recent findings that may provide a safe, effective prophylaxis and therapy.
Udgivelsesdato: 2008-Feb-4

Translated title of the contribution	Neisseria meningitidis. The pathophysiological role of lipopolysaccharides in association with meningococcal disease and septic shock
Original language	Danish
Journal	Ugeskrift for læger
Volume	170
Issue number	6
Pages (from-to)	421-6
Number of pages	5
ISSN	0041-5782
Publication status	Published - 2008

Cite this

@article{98d89040f91211ddb219000ea68e967b,

title = "Neisseria meningitidis. Lipopolysakkariders patofysiologiske rolle ved meningokoksygdom og septisk shock",

abstract = "A major pro-inflammatory and toxic component of N. meningitidis is lipopolysaccharide (LPS). LPS contributes to severe symptoms of meningococcal disease, septic shock and severe coagulopathy, in part by increasing pro-inflammatory mechanisms and reactive oxygen species. Recent technologies have increased the likelihood of developing an anti-meningococcal immunization strategy based upon the virulence of LPS which may lead to a vaccination against this important pathogen including serogroup B disease. This review summarizes recent findings that may provide a safe, effective prophylaxis and therapy. Udgivelsesdato: 2008-Feb-4",

author = "Pedersen, {Mie {\O}stergaard} and Pedersen, {Dan Sonne} and Michael Pedersen and Milena Penkowa",

note = "Keywords: Anti-Bacterial Agents; Humans; Lipopolysaccharides; Meningococcal Infections; Meningococcal Vaccines; Neisseria meningitidis; Neisseria meningitidis, Serogroup B; Shock, Septic; Virulence",

year = "2008",

language = "Dansk",

volume = "170",

pages = "421--6",

journal = "Ugeskrift for Laeger",

issn = "0041-5782",

publisher = "Almindelige Danske Laegeforening",

number = "6",

}

TY - JOUR

T1 - Neisseria meningitidis. Lipopolysakkariders patofysiologiske rolle ved meningokoksygdom og septisk shock

AU - Pedersen, Mie Østergaard

AU - Pedersen, Dan Sonne

AU - Pedersen, Michael

AU - Penkowa, Milena

N1 - Keywords: Anti-Bacterial Agents; Humans; Lipopolysaccharides; Meningococcal Infections; Meningococcal Vaccines; Neisseria meningitidis; Neisseria meningitidis, Serogroup B; Shock, Septic; Virulence

PY - 2008

Y1 - 2008

N2 - A major pro-inflammatory and toxic component of N. meningitidis is lipopolysaccharide (LPS). LPS contributes to severe symptoms of meningococcal disease, septic shock and severe coagulopathy, in part by increasing pro-inflammatory mechanisms and reactive oxygen species. Recent technologies have increased the likelihood of developing an anti-meningococcal immunization strategy based upon the virulence of LPS which may lead to a vaccination against this important pathogen including serogroup B disease. This review summarizes recent findings that may provide a safe, effective prophylaxis and therapy. Udgivelsesdato: 2008-Feb-4

AB - A major pro-inflammatory and toxic component of N. meningitidis is lipopolysaccharide (LPS). LPS contributes to severe symptoms of meningococcal disease, septic shock and severe coagulopathy, in part by increasing pro-inflammatory mechanisms and reactive oxygen species. Recent technologies have increased the likelihood of developing an anti-meningococcal immunization strategy based upon the virulence of LPS which may lead to a vaccination against this important pathogen including serogroup B disease. This review summarizes recent findings that may provide a safe, effective prophylaxis and therapy. Udgivelsesdato: 2008-Feb-4

M3 - Tidsskriftartikel

C2 - 18252172

SN - 0041-5782

VL - 170

SP - 421

EP - 426

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 6

ER -