Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetes

P V Højberg; Pär-Ola Mikael Zander; Tina Vilsbøll; F K Knop; T Krarup; Anders Vølund; Jens Møller Holst; S Madsbad

doi:10.1007/s00125-008-0943-x

Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetes

P V Højberg, Pär-Ola Mikael Zander, Tina Vilsbøll, F K Knop, T Krarup, Anders Vølund, Jens Møller Holst, S Madsbad

Department of Clinical Medicine

69 Citations (Scopus)

Abstract

The ability of glucagon-like peptide-1 (GLP-1) to enhance beta cell responsiveness to i.v. glucose is impaired in patients with type 2 diabetes mellitus compared with healthy individuals. We investigated whether 4 weeks of near normalisation of blood glucose (BG) improves the potentiation of glucose-stimulated insulin secretion by GLP-1.

Original language	English
Journal	Diabetologia
Volume	51
Issue number	4
Pages (from-to)	632-40
Number of pages	9
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s00125-008-0943-x https://doi.org/10.1007/s00125-008-0943-x
Publication status	Published - 1 Apr 2008

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Højberg, P. V., Zander, P-O. M., Vilsbøll, T., Knop, F. K., Krarup, T., Vølund, A., Holst, J. M., & Madsbad, S. (2008). Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetes. Diabetologia, 51(4), 632-40. https://doi.org/10.1007/s00125-008-0943-x, https://doi.org/10.1007/s00125-008-0943-x

Højberg, PV, Zander, P-OM, Vilsbøll, T , Knop, FK, Krarup, T, Vølund, A, Holst, JM & Madsbad, S 2008, 'Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetes', Diabetologia, vol. 51, no. 4, pp. 632-40. https://doi.org/10.1007/s00125-008-0943-x, https://doi.org/10.1007/s00125-008-0943-x

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AU - Knop, F K

AU - Krarup, T

AU - Vølund, Anders

AU - Holst, Jens Møller

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AB - The ability of glucagon-like peptide-1 (GLP-1) to enhance beta cell responsiveness to i.v. glucose is impaired in patients with type 2 diabetes mellitus compared with healthy individuals. We investigated whether 4 weeks of near normalisation of blood glucose (BG) improves the potentiation of glucose-stimulated insulin secretion by GLP-1.

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Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetes

Abstract

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