Near-Neighbor Interactions in the NS3-4A Protease of HCV Impact Replicative Fitness of Drug-Resistant Viral Variants

Nadezhda T. Doncheva; Francisco S. Domingues; David R. McGivern; Tetsuro Shimakami; Stefan Zeuzem; Thomas Lengauer; Christian M. Lange; Mario Albrecht; Christoph Welsch

doi:10.1016/j.jmb.2019.04.034

Near-Neighbor Interactions in the NS3-4A Protease of HCV Impact Replicative Fitness of Drug-Resistant Viral Variants

Nadezhda T. Doncheva, Francisco S. Domingues, David R. McGivern, Tetsuro Shimakami, Stefan Zeuzem, Thomas Lengauer, Christian M. Lange, Mario Albrecht, Christoph Welsch

1 Citation (Scopus)

Original language	English
Journal	Journal of Molecular Biology
Volume	431
Issue number	12
Pages (from-to)	2354-2368
ISSN	0022-2836
DOIs	https://doi.org/10.1016/j.jmb.2019.04.034
Publication status	Published - 31 May 2019
Externally published	Yes

Keywords

hepatitis C virus
subtype
viral variant fitness
residue networks
molecular determinants

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jmb.2019.04.034

Cite this

@article{82cb0ce4a4a04893a28ce6a3e57cdd2b,

title = "Near-Neighbor Interactions in the NS3-4A Protease of HCV Impact Replicative Fitness of Drug-Resistant Viral Variants",

keywords = "hepatitis C virus, subtype, viral variant fitness, residue networks, molecular determinants",

author = "Doncheva, {Nadezhda T.} and Domingues, {Francisco S.} and McGivern, {David R.} and Tetsuro Shimakami and Stefan Zeuzem and Thomas Lengauer and Lange, {Christian M.} and Mario Albrecht and Christoph Welsch",

year = "2019",

month = may,

day = "31",

doi = "10.1016/j.jmb.2019.04.034",

language = "English",

volume = "431",

pages = "2354--2368",

journal = "Journal of Molecular Biology",

issn = "0022-2836",

publisher = "Academic Press",

number = "12",

}

TY - JOUR

T1 - Near-Neighbor Interactions in the NS3-4A Protease of HCV Impact Replicative Fitness of Drug-Resistant Viral Variants

AU - Doncheva, Nadezhda T.

AU - Domingues, Francisco S.

AU - McGivern, David R.

AU - Shimakami, Tetsuro

AU - Zeuzem, Stefan

AU - Lengauer, Thomas

AU - Lange, Christian M.

AU - Albrecht, Mario

AU - Welsch, Christoph

PY - 2019/5/31

Y1 - 2019/5/31

KW - hepatitis C virus

KW - subtype

KW - viral variant fitness

KW - residue networks

KW - molecular determinants

U2 - 10.1016/j.jmb.2019.04.034

DO - 10.1016/j.jmb.2019.04.034

M3 - Journal article

C2 - 31051172

SN - 0022-2836

VL - 431

SP - 2354

EP - 2368

JO - Journal of Molecular Biology

JF - Journal of Molecular Biology

IS - 12

ER -

Near-Neighbor Interactions in the NS3-4A Protease of HCV Impact Replicative Fitness of Drug-Resistant Viral Variants

Keywords

UN SDGs

Access to Document

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Cite this