Near-haploid and low-hypodiploid acute lymphoblastic leukemia: Two distinct subtypes with consistently poor prognosis

TY - JOUR

T1 - Near-haploid and low-hypodiploid acute lymphoblastic leukemia

T2 - Two distinct subtypes with consistently poor prognosis

AU - Safavi, Setareh

AU - Paulsson, Kajsa

PY - 2017/1/26

Y1 - 2017/1/26

N2 - Hypodiploidy <40 chromosomes is an uncommon genetic feature of acute lymphoblastic leukemia (ALL) in both children and adults. It has long been clear by cytogenetic analyses, and recently confirmed by mutational profiling, that these cases may be further subdivided into 2 subtypes: near-haploid ALL with 24 to 30 chromosomes and low-hypodiploid ALL with 31 to 39 chromosomes. Both groups are associated with a very poor prognosis, and these patients are among those who could benefit most from novel treatments.

AB - Hypodiploidy <40 chromosomes is an uncommon genetic feature of acute lymphoblastic leukemia (ALL) in both children and adults. It has long been clear by cytogenetic analyses, and recently confirmed by mutational profiling, that these cases may be further subdivided into 2 subtypes: near-haploid ALL with 24 to 30 chromosomes and low-hypodiploid ALL with 31 to 39 chromosomes. Both groups are associated with a very poor prognosis, and these patients are among those who could benefit most from novel treatments.

U2 - 10.1182/blood-2016-10-743765

DO - 10.1182/blood-2016-10-743765

M3 - Review

C2 - 27903530

AN - SCOPUS:85014910236

SN - 0006-4971

VL - 129

SP - 420

EP - 423

JO - Blood

JF - Blood

IS - 4

ER -