Naturally acquired antibodies to the glutamate-rich protein are associated with protection against Plasmodium falciparum malaria

TY - JOUR

T1 - Naturally acquired antibodies to the glutamate-rich protein are associated with protection against Plasmodium falciparum malaria

AU - Dodoo, D

AU - Theisen, M

AU - Kurtzhals, J A

AU - Akanmori, B D

AU - Koram, K A

AU - Jepsen, S

AU - Nkrumah, F K

AU - Theander, T G

AU - Hviid, L

N1 - Keywords: Adolescent; Animals; Antibodies, Protozoan; Child; Child, Preschool; Female; Humans; Immunoglobulin G; Immunoglobulin M; Malaria, Falciparum; Male; Plasmodium falciparum; Protozoan Proteins; Recombinant Proteins

PY - 2000

Y1 - 2000

N2 - The development of effective malaria vaccines depends on the identification of targets of well-defined protective immune responses. Data and samples from a longitudinal study of a cohort of children from coastal Ghana were used to investigate the role of antibody responses to 3 regions of the Plasmodium falciparum glutamate-rich protein (GLURP). The data show that levels of the GLURP-specific IgG that occurs in the nonrepeat region of the antigen are significantly correlated with clinical protection from P. falciparum malaria, after correction for the confounding effect of age. Furthermore, levels of cytophilic antibodies were found to be of particular importance for protection, lending support to the hypothesis that antibody-dependent cellular inhibition is the important element in GLURP-specific protective immunity.

AB - The development of effective malaria vaccines depends on the identification of targets of well-defined protective immune responses. Data and samples from a longitudinal study of a cohort of children from coastal Ghana were used to investigate the role of antibody responses to 3 regions of the Plasmodium falciparum glutamate-rich protein (GLURP). The data show that levels of the GLURP-specific IgG that occurs in the nonrepeat region of the antigen are significantly correlated with clinical protection from P. falciparum malaria, after correction for the confounding effect of age. Furthermore, levels of cytophilic antibodies were found to be of particular importance for protection, lending support to the hypothesis that antibody-dependent cellular inhibition is the important element in GLURP-specific protective immunity.

U2 - 10.1086/315341

DO - 10.1086/315341

M3 - Journal article

C2 - 10720556

SN - 0022-1899

VL - 181

SP - 1202

EP - 1205

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 3

ER -