TY - JOUR
T1 - Natriuretic pro-peptides in idiopathic intracranial hypertension
AU - Skau, Maren Cecilie Kloppenbor
AU - Gøtze, Jens Peter
AU - Rehfeld, Jens F.
AU - Jensen, Rigmor Højland
N1 - Copyright 2010 Elsevier B.V. All rights reserved.
PY - 2010/9/24
Y1 - 2010/9/24
N2 - Idiopathic intracranial hypertension is a disorder of unknown pathogenesis. Natriuretic peptides may be involved in intracranial pressure regulation, but cerebrospinal fluid (CNS) and plasma concentrations in this disorder are unknown. We evaluated venous and intrathecal concentrations of ANP, BNP and CNP precursor peptides in 40 patients with idiopathic intracranial hypertension and in 20 controls. Natriuretic pro-peptides were quantitated using processing-independent assays. In CSF, no differences in peptide concentrations between patients and controls were found (proANP: 239 ± 23 vs 231 ± 22. pmol/L, proBNP: < 2 pmol/L in all, proCNP: 1079 ± 318 vs 1138 ± 323. pmol/L). In plasma, proCNP was lower in IIH compared with controls (35.3 ± 4.8 pmol/L vs 43.8 ± 5.9. pmol/L, p<0.0001). Moreover, plasma proBNP was significantly lower in patients compared with controls (47.1 ± 21.4pmol/L vs 59.2 ± 22.0. pmol/L, p=0.045). There were no associations between peptide concentrations and ICP and BMI, respectively. Plasma proANP and proCNP increased during 3. months follow-up (p=0.01 and p=0.006), n=12. We suggest that decreased plasma proCNP concentration in idiopathic intracranial hypertension may reflect endothelial dysregulation of vascular tone and may be a marker in this disease. Further studies of proCNP and endothelial function are needed to establish such role.
AB - Idiopathic intracranial hypertension is a disorder of unknown pathogenesis. Natriuretic peptides may be involved in intracranial pressure regulation, but cerebrospinal fluid (CNS) and plasma concentrations in this disorder are unknown. We evaluated venous and intrathecal concentrations of ANP, BNP and CNP precursor peptides in 40 patients with idiopathic intracranial hypertension and in 20 controls. Natriuretic pro-peptides were quantitated using processing-independent assays. In CSF, no differences in peptide concentrations between patients and controls were found (proANP: 239 ± 23 vs 231 ± 22. pmol/L, proBNP: < 2 pmol/L in all, proCNP: 1079 ± 318 vs 1138 ± 323. pmol/L). In plasma, proCNP was lower in IIH compared with controls (35.3 ± 4.8 pmol/L vs 43.8 ± 5.9. pmol/L, p<0.0001). Moreover, plasma proBNP was significantly lower in patients compared with controls (47.1 ± 21.4pmol/L vs 59.2 ± 22.0. pmol/L, p=0.045). There were no associations between peptide concentrations and ICP and BMI, respectively. Plasma proANP and proCNP increased during 3. months follow-up (p=0.01 and p=0.006), n=12. We suggest that decreased plasma proCNP concentration in idiopathic intracranial hypertension may reflect endothelial dysregulation of vascular tone and may be a marker in this disease. Further studies of proCNP and endothelial function are needed to establish such role.
U2 - 10.1016/j.regpep.2010.05.009
DO - 10.1016/j.regpep.2010.05.009
M3 - Journal article
SN - 0167-0115
VL - 164
SP - 71
EP - 77
JO - Regulatory Peptides
JF - Regulatory Peptides
IS - 2-3
ER -