Narcolepsy and pregnancy: a retrospective European evaluation of 249 pregnancies

Eszter Maurovich-Horvat; David Kemlink; Birgit Högl; Birgit Frauscher; Laura Ehrmann; Peter Geisler; Katharina Ettenhuber; Geert Mayer; Rosa Peraita-Adrados; Elena Calvo; Gert Jan Lammers; Astrid Van der Heide; Luigi Ferini-Strambi; Giuseppe Plazzi; Francesca Poli; Yves Dauvilliers; Poul Jennum; Helle Leonthin; Johannes Mathis; Aleksandra Wierzbicka; Francisco J Puertas; Pierre A Beitinger; Isabelle Arnulf; Renata L Riha; Maria Tormášiová; Jana Slonková; Sona Nevšímalová; Karel Sonka; European Narcolepsy Network

doi:10.1111/jsr.12047

Narcolepsy and pregnancy: a retrospective European evaluation of 249 pregnancies

Eszter Maurovich-Horvat, David Kemlink, Birgit Högl, Birgit Frauscher, Laura Ehrmann, Peter Geisler, Katharina Ettenhuber, Geert Mayer, Rosa Peraita-Adrados, Elena Calvo, Gert Jan Lammers, Astrid Van der Heide, Luigi Ferini-Strambi, Giuseppe Plazzi, Francesca Poli, Yves Dauvilliers, Poul Jennum, Helle Leonthin, Johannes Mathis, Aleksandra WierzbickaFrancisco J Puertas, Pierre A Beitinger, Isabelle Arnulf, Renata L Riha, Maria Tormášiová, Jana Slonková, Sona Nevšímalová, Karel Sonka, European Narcolepsy Network

37 Citations (Scopus)

Abstract

In a retrospective cohort study undertaken in 12 European countries, 249 female narcoleptic patients with cataplexy (n = 216) and without cataplexy (n = 33) completed a self-administrated questionnaire regarding pregnancy and childbirth. The cohort was divided further into patients whose symptoms of narcolepsy started before or during pregnancy (308 pregnancies) and those in whom the first symptoms of narcolepsy appeared after delivery (106 pregnancies). Patients with narcolepsy during pregnancy were older during their first pregnancy (P < 0.001) and had a higher body mass index (BMI) prior to pregnancy (P < 0.01). Weight gain during pregnancy was higher in narcoleptic patients with cataplexy (P < 0.01). More patients with narcolepsy-cataplexy during pregnancy had impaired glucose metabolism and anaemia. Three patients experienced cataplexy during delivery. The rate of caesarean sections was higher in the narcolepsy-cataplexy group compared to the narcolepsy group (P < 0.05). The mean birth weight and gestational age of neonates were within the normal range and did not differ across groups. Neonatal care was affected adversely by symptoms of narcolepsy in 60.1% of those with narcolepsy during pregnancy. This study reports more obstetric complications in patients with narcolepsy-cataplexy during pregnancy; however, these were not severe. This group also had a higher BMI and higher incidence of impaired glucose metabolism during pregnancy. Caesarian section was conducted more frequently in narcolepsy-cataplexy patients, despite cataplexy being a rare event during delivery. Furthermore, symptoms of narcolepsy may render care of the infant more difficult.

Original language	English
Journal	Journal of Sleep Research Online
Volume	22
Issue number	5
Pages (from-to)	496-512
Number of pages	17
ISSN	1365-2869
DOIs	https://doi.org/10.1111/jsr.12047
Publication status	Published - Oct 2013

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Maurovich-Horvat, E., Kemlink, D., Högl, B., Frauscher, B., Ehrmann, L., Geisler, P., Ettenhuber, K., Mayer, G., Peraita-Adrados, R., Calvo, E., Lammers, G. J., Van der Heide, A., Ferini-Strambi, L., Plazzi, G., Poli, F., Dauvilliers, Y., Jennum, P., Leonthin, H., Mathis, J., ... Network, E. N. (2013). Narcolepsy and pregnancy: a retrospective European evaluation of 249 pregnancies . Journal of Sleep Research Online, 22(5), 496-512. https://doi.org/10.1111/jsr.12047

Maurovich-Horvat, E, Kemlink, D, Högl, B, Frauscher, B, Ehrmann, L, Geisler, P, Ettenhuber, K, Mayer, G, Peraita-Adrados, R, Calvo, E, Lammers, GJ, Van der Heide, A, Ferini-Strambi, L, Plazzi, G, Poli, F, Dauvilliers, Y, Jennum, P, Leonthin, H, Mathis, J, Wierzbicka, A, Puertas, FJ, Beitinger, PA, Arnulf, I, Riha, RL, Tormášiová, M, Slonková, J, Nevšímalová, S, Sonka, K & Network, EN 2013, 'Narcolepsy and pregnancy: a retrospective European evaluation of 249 pregnancies ', Journal of Sleep Research Online, vol. 22, no. 5, pp. 496-512. https://doi.org/10.1111/jsr.12047

@article{cbaf649184004a03a44df1c73d985497,

title = "Narcolepsy and pregnancy: a retrospective European evaluation of 249 pregnancies ",

abstract = "In a retrospective cohort study undertaken in 12 European countries, 249 female narcoleptic patients with cataplexy (n = 216) and without cataplexy (n = 33) completed a self-administrated questionnaire regarding pregnancy and childbirth. The cohort was divided further into patients whose symptoms of narcolepsy started before or during pregnancy (308 pregnancies) and those in whom the first symptoms of narcolepsy appeared after delivery (106 pregnancies). Patients with narcolepsy during pregnancy were older during their first pregnancy (P < 0.001) and had a higher body mass index (BMI) prior to pregnancy (P < 0.01). Weight gain during pregnancy was higher in narcoleptic patients with cataplexy (P < 0.01). More patients with narcolepsy-cataplexy during pregnancy had impaired glucose metabolism and anaemia. Three patients experienced cataplexy during delivery. The rate of caesarean sections was higher in the narcolepsy-cataplexy group compared to the narcolepsy group (P < 0.05). The mean birth weight and gestational age of neonates were within the normal range and did not differ across groups. Neonatal care was affected adversely by symptoms of narcolepsy in 60.1% of those with narcolepsy during pregnancy. This study reports more obstetric complications in patients with narcolepsy-cataplexy during pregnancy; however, these were not severe. This group also had a higher BMI and higher incidence of impaired glucose metabolism during pregnancy. Caesarian section was conducted more frequently in narcolepsy-cataplexy patients, despite cataplexy being a rare event during delivery. Furthermore, symptoms of narcolepsy may render care of the infant more difficult.",

author = "Eszter Maurovich-Horvat and David Kemlink and Birgit H{\"o}gl and Birgit Frauscher and Laura Ehrmann and Peter Geisler and Katharina Ettenhuber and Geert Mayer and Rosa Peraita-Adrados and Elena Calvo and Lammers, {Gert Jan} and {Van der Heide}, Astrid and Luigi Ferini-Strambi and Giuseppe Plazzi and Francesca Poli and Yves Dauvilliers and Poul Jennum and Helle Leonthin and Johannes Mathis and Aleksandra Wierzbicka and Puertas, {Francisco J} and Beitinger, {Pierre A} and Isabelle Arnulf and Riha, {Renata L} and Maria Torm{\'a}{\v s}iov{\'a} and Jana Slonkov{\'a} and Sona Nev{\v s}{\'i}malov{\'a} and Karel Sonka and Network, {European Narcolepsy}",

year = "2013",

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doi = "10.1111/jsr.12047",

language = "English",

volume = "22",

pages = "496--512",

journal = "Journal of Sleep Research",

issn = "1365-2869",

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TY - JOUR

T1 - Narcolepsy and pregnancy

T2 - a retrospective European evaluation of 249 pregnancies

AU - Maurovich-Horvat, Eszter

AU - Kemlink, David

AU - Högl, Birgit

AU - Frauscher, Birgit

AU - Ehrmann, Laura

AU - Geisler, Peter

AU - Ettenhuber, Katharina

AU - Mayer, Geert

AU - Peraita-Adrados, Rosa

AU - Calvo, Elena

AU - Lammers, Gert Jan

AU - Van der Heide, Astrid

AU - Ferini-Strambi, Luigi

AU - Plazzi, Giuseppe

AU - Poli, Francesca

AU - Dauvilliers, Yves

AU - Jennum, Poul

AU - Leonthin, Helle

AU - Mathis, Johannes

AU - Wierzbicka, Aleksandra

AU - Puertas, Francisco J

AU - Beitinger, Pierre A

AU - Arnulf, Isabelle

AU - Riha, Renata L

AU - Tormášiová, Maria

AU - Slonková, Jana

AU - Nevšímalová, Sona

AU - Sonka, Karel

AU - Network, European Narcolepsy

PY - 2013/10

Y1 - 2013/10

N2 - In a retrospective cohort study undertaken in 12 European countries, 249 female narcoleptic patients with cataplexy (n = 216) and without cataplexy (n = 33) completed a self-administrated questionnaire regarding pregnancy and childbirth. The cohort was divided further into patients whose symptoms of narcolepsy started before or during pregnancy (308 pregnancies) and those in whom the first symptoms of narcolepsy appeared after delivery (106 pregnancies). Patients with narcolepsy during pregnancy were older during their first pregnancy (P < 0.001) and had a higher body mass index (BMI) prior to pregnancy (P < 0.01). Weight gain during pregnancy was higher in narcoleptic patients with cataplexy (P < 0.01). More patients with narcolepsy-cataplexy during pregnancy had impaired glucose metabolism and anaemia. Three patients experienced cataplexy during delivery. The rate of caesarean sections was higher in the narcolepsy-cataplexy group compared to the narcolepsy group (P < 0.05). The mean birth weight and gestational age of neonates were within the normal range and did not differ across groups. Neonatal care was affected adversely by symptoms of narcolepsy in 60.1% of those with narcolepsy during pregnancy. This study reports more obstetric complications in patients with narcolepsy-cataplexy during pregnancy; however, these were not severe. This group also had a higher BMI and higher incidence of impaired glucose metabolism during pregnancy. Caesarian section was conducted more frequently in narcolepsy-cataplexy patients, despite cataplexy being a rare event during delivery. Furthermore, symptoms of narcolepsy may render care of the infant more difficult.

AB - In a retrospective cohort study undertaken in 12 European countries, 249 female narcoleptic patients with cataplexy (n = 216) and without cataplexy (n = 33) completed a self-administrated questionnaire regarding pregnancy and childbirth. The cohort was divided further into patients whose symptoms of narcolepsy started before or during pregnancy (308 pregnancies) and those in whom the first symptoms of narcolepsy appeared after delivery (106 pregnancies). Patients with narcolepsy during pregnancy were older during their first pregnancy (P < 0.001) and had a higher body mass index (BMI) prior to pregnancy (P < 0.01). Weight gain during pregnancy was higher in narcoleptic patients with cataplexy (P < 0.01). More patients with narcolepsy-cataplexy during pregnancy had impaired glucose metabolism and anaemia. Three patients experienced cataplexy during delivery. The rate of caesarean sections was higher in the narcolepsy-cataplexy group compared to the narcolepsy group (P < 0.05). The mean birth weight and gestational age of neonates were within the normal range and did not differ across groups. Neonatal care was affected adversely by symptoms of narcolepsy in 60.1% of those with narcolepsy during pregnancy. This study reports more obstetric complications in patients with narcolepsy-cataplexy during pregnancy; however, these were not severe. This group also had a higher BMI and higher incidence of impaired glucose metabolism during pregnancy. Caesarian section was conducted more frequently in narcolepsy-cataplexy patients, despite cataplexy being a rare event during delivery. Furthermore, symptoms of narcolepsy may render care of the infant more difficult.

U2 - 10.1111/jsr.12047

DO - 10.1111/jsr.12047

M3 - Journal article

C2 - 23560595

SN - 1365-2869

VL - 22

SP - 496

EP - 512

JO - Journal of Sleep Research

JF - Journal of Sleep Research

IS - 5

ER -

Narcolepsy and pregnancy: a retrospective European evaluation of 249 pregnancies

Abstract

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