Nanomechanical Infrared Spectroscopy with Vibrating Filters for Pharmaceutical Analysis

Maksymilian Kurek; Matthias Carnoy; Peter E Larsen; Line H Nielsen; Ole Hansen; Thomas Rades; Silvan Schmid; Anja Boisen

doi:10.1002/anie.201700052

Nanomechanical Infrared Spectroscopy with Vibrating Filters for Pharmaceutical Analysis

Maksymilian Kurek, Matthias Carnoy, Peter E Larsen, Line H Nielsen, Ole Hansen, Thomas Rades, Silvan Schmid, Anja Boisen

14 Citations (Scopus)

Abstract

Standard infrared spectroscopy techniques are well-developed and widely used. However, they typically require milligrams of sample and can involve time-consuming sample preparation. A promising alternative is represented by nanomechanical infrared spectroscopy (NAM-IR) based on the photothermal response of a nanomechanical resonator, which enables the chemical analysis of picograms of analyte directly from a liquid solution in only a few minutes. Herein, we present NAM-IR using perforated membranes (filters). The method was tested with the pharmaceutical compound indomethacin to successfully perform a chemical and morphological analysis on roughly 100 pg of sample. With an absolute estimated sensitivity of 109±15 fg, the presented method is suitable for ultrasensitive vibrational spectroscopy.

Original language	English
Journal	Angewandte Chemie (International ed. in English)
Volume	56
Issue number	14
Pages (from-to)	3901-3905
Number of pages	5
ISSN	1433-7851
DOIs	https://doi.org/10.1002/anie.201700052
Publication status	Published - 27 Mar 2017

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abstract = "Standard infrared spectroscopy techniques are well-developed and widely used. However, they typically require milligrams of sample and can involve time-consuming sample preparation. A promising alternative is represented by nanomechanical infrared spectroscopy (NAM-IR) based on the photothermal response of a nanomechanical resonator, which enables the chemical analysis of picograms of analyte directly from a liquid solution in only a few minutes. Herein, we present NAM-IR using perforated membranes (filters). The method was tested with the pharmaceutical compound indomethacin to successfully perform a chemical and morphological analysis on roughly 100 pg of sample. With an absolute estimated sensitivity of 109±15 fg, the presented method is suitable for ultrasensitive vibrational spectroscopy.",

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AU - Kurek, Maksymilian

AU - Carnoy, Matthias

AU - Larsen, Peter E

AU - Nielsen, Line H

AU - Hansen, Ole

AU - Rades, Thomas

AU - Schmid, Silvan

AU - Boisen, Anja

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AB - Standard infrared spectroscopy techniques are well-developed and widely used. However, they typically require milligrams of sample and can involve time-consuming sample preparation. A promising alternative is represented by nanomechanical infrared spectroscopy (NAM-IR) based on the photothermal response of a nanomechanical resonator, which enables the chemical analysis of picograms of analyte directly from a liquid solution in only a few minutes. Herein, we present NAM-IR using perforated membranes (filters). The method was tested with the pharmaceutical compound indomethacin to successfully perform a chemical and morphological analysis on roughly 100 pg of sample. With an absolute estimated sensitivity of 109±15 fg, the presented method is suitable for ultrasensitive vibrational spectroscopy.

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Nanomechanical Infrared Spectroscopy with Vibrating Filters for Pharmaceutical Analysis

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