Myocardial perfusion at rest in patients with Diabetes Mellitus Type 1 compared with healthy controls assessed with Multi Detector Computed Tomography

Christina Byrne; Tonny Jensen; Henrik Øder Hjortkjær; Ulrik Madvig Mogensen; Jørgen Tobias Kühl; Andreas Fuchs; Jannik Hilsted; Børge G Nordestgaard; Lars Køber; K F Kofoed

doi:10.1016/j.diabres.2014.10.011

Myocardial perfusion at rest in patients with Diabetes Mellitus Type 1 compared with healthy controls assessed with Multi Detector Computed Tomography

Christina Byrne, Tonny Jensen, Henrik Øder Hjortkjær, Ulrik Madvig Mogensen, Jørgen Tobias Kühl, Andreas Fuchs, Jannik Hilsted, Børge G Nordestgaard, Lars Køber, K F Kofoed

Department of Clinical Medicine

5 Citations (Scopus)

Abstract

AIM: Type 1 diabetes mellitus (T1DM) is associated with an increased risk of ischemic heart disease (IHD). The relative contribution of structural and functional abnormalities of the coronary circulation determining clinically manifested IHD remains unknown. The aim of this study was to assess potential differences in myocardial perfusion at rest and coronary atherosclerosis between asymptomatic T1DM patients and healthy controls.

METHODS: Left ventricular (LV) myocardial perfusion at rest measured as LV myocardial Attenuation Density/LV blood pool Attenuation Density (MyoAD-ratio) and coronary artery atherosclerosis were evaluated with 320-multidetector computed tomography angiography in 57 asymptomatic T1DM patients and 114 sex and age matched controls.

RESULTS: In both groups median age was 53 years (p5,p95: 42,67) and 59.6% were men. Median duration of diabetes in the T1DM group was 35 years (p5,p95: 17,49). Median coronary calcium score was higher in T1DM patients (51 vs. 2, p=0.037) compared with controls. However, a similar frequency of >50% stenosis in one or more coronary arteries was found in T1DM patients and controls (18% vs. 14%, p=0.49). LV myocardial perfusion at rest (MyoAD-ratio) was 18% higher in T1DM patients than controls (0.13 vs. 0.11, p<0.0001). This difference was noted throughout all the LV myocardial segments. In a multiple regression analysis including diabetes, sex, age, cardiovascular risk factors, heart rate, calcium score and coronary stenosis >50%, MyoAD-ratio remained significantly higher in T1DM patients (p=0.0001).

CONCLUSIONS: LV myocardial perfusion at rest is higher in T1DM patients compared with controls independent of coronary atherosclerosis and cardiovascular risk factors.

Original language	English
Journal	Diabetes Research and Clinical Practice
Volume	107
Issue number	1
Pages (from-to)	15-22
Number of pages	8
ISSN	0168-8227
DOIs	https://doi.org/10.1016/j.diabres.2014.10.011
Publication status	Published - Jan 2015

Keywords

Adult
Aged
Case-Control Studies
Diabetes Mellitus, Type 1
Female
Humans
Male
Middle Aged
Myocardial Ischemia
Risk Factors
Tomography, X-Ray Computed

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diabres.2014.10.011

Cite this

Byrne, C., Jensen, T., Hjortkjær, H. Ø., Mogensen, U. M., Kühl, J. T., Fuchs, A., Hilsted, J., Nordestgaard, B. G., Køber, L., & Kofoed, K. F. (2015). Myocardial perfusion at rest in patients with Diabetes Mellitus Type 1 compared with healthy controls assessed with Multi Detector Computed Tomography. Diabetes Research and Clinical Practice, 107(1), 15-22. https://doi.org/10.1016/j.diabres.2014.10.011

Myocardial perfusion at rest in patients with Diabetes Mellitus Type 1 compared with healthy controls assessed with Multi Detector Computed Tomography. / Byrne, Christina; Jensen, Tonny; Hjortkjær, Henrik Øder et al.

In: Diabetes Research and Clinical Practice, Vol. 107, No. 1, 01.2015, p. 15-22.

Research output: Contribution to journal › Journal article › Research › peer-review

Byrne, C, Jensen, T, Hjortkjær, HØ, Mogensen, UM, Kühl, JT, Fuchs, A, Hilsted, J, Nordestgaard, BG , Køber, L & Kofoed, KF 2015, 'Myocardial perfusion at rest in patients with Diabetes Mellitus Type 1 compared with healthy controls assessed with Multi Detector Computed Tomography', Diabetes Research and Clinical Practice, vol. 107, no. 1, pp. 15-22. https://doi.org/10.1016/j.diabres.2014.10.011

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title = "Myocardial perfusion at rest in patients with Diabetes Mellitus Type 1 compared with healthy controls assessed with Multi Detector Computed Tomography",

abstract = "AIM: Type 1 diabetes mellitus (T1DM) is associated with an increased risk of ischemic heart disease (IHD). The relative contribution of structural and functional abnormalities of the coronary circulation determining clinically manifested IHD remains unknown. The aim of this study was to assess potential differences in myocardial perfusion at rest and coronary atherosclerosis between asymptomatic T1DM patients and healthy controls.METHODS: Left ventricular (LV) myocardial perfusion at rest measured as LV myocardial Attenuation Density/LV blood pool Attenuation Density (MyoAD-ratio) and coronary artery atherosclerosis were evaluated with 320-multidetector computed tomography angiography in 57 asymptomatic T1DM patients and 114 sex and age matched controls.RESULTS: In both groups median age was 53 years (p5,p95: 42,67) and 59.6% were men. Median duration of diabetes in the T1DM group was 35 years (p5,p95: 17,49). Median coronary calcium score was higher in T1DM patients (51 vs. 2, p=0.037) compared with controls. However, a similar frequency of >50% stenosis in one or more coronary arteries was found in T1DM patients and controls (18% vs. 14%, p=0.49). LV myocardial perfusion at rest (MyoAD-ratio) was 18% higher in T1DM patients than controls (0.13 vs. 0.11, p<0.0001). This difference was noted throughout all the LV myocardial segments. In a multiple regression analysis including diabetes, sex, age, cardiovascular risk factors, heart rate, calcium score and coronary stenosis >50%, MyoAD-ratio remained significantly higher in T1DM patients (p=0.0001).CONCLUSIONS: LV myocardial perfusion at rest is higher in T1DM patients compared with controls independent of coronary atherosclerosis and cardiovascular risk factors.",

keywords = "Adult, Aged, Case-Control Studies, Diabetes Mellitus, Type 1, Female, Humans, Male, Middle Aged, Myocardial Ischemia, Risk Factors, Tomography, X-Ray Computed",

author = "Christina Byrne and Tonny Jensen and Hjortkj{\ae}r, {Henrik {\O}der} and Mogensen, {Ulrik Madvig} and K{\"u}hl, {J{\o}rgen Tobias} and Andreas Fuchs and Jannik Hilsted and Nordestgaard, {B{\o}rge G} and Lars K{\o}ber and Kofoed, {K F}",

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doi = "10.1016/j.diabres.2014.10.011",

language = "English",

volume = "107",

pages = "15--22",

journal = "Diabetes Research and Clinical Practice",

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T1 - Myocardial perfusion at rest in patients with Diabetes Mellitus Type 1 compared with healthy controls assessed with Multi Detector Computed Tomography

AU - Byrne, Christina

AU - Jensen, Tonny

AU - Hjortkjær, Henrik Øder

AU - Mogensen, Ulrik Madvig

AU - Kühl, Jørgen Tobias

AU - Fuchs, Andreas

AU - Hilsted, Jannik

AU - Nordestgaard, Børge G

AU - Køber, Lars

AU - Kofoed, K F

PY - 2015/1

Y1 - 2015/1

N2 - AIM: Type 1 diabetes mellitus (T1DM) is associated with an increased risk of ischemic heart disease (IHD). The relative contribution of structural and functional abnormalities of the coronary circulation determining clinically manifested IHD remains unknown. The aim of this study was to assess potential differences in myocardial perfusion at rest and coronary atherosclerosis between asymptomatic T1DM patients and healthy controls.METHODS: Left ventricular (LV) myocardial perfusion at rest measured as LV myocardial Attenuation Density/LV blood pool Attenuation Density (MyoAD-ratio) and coronary artery atherosclerosis were evaluated with 320-multidetector computed tomography angiography in 57 asymptomatic T1DM patients and 114 sex and age matched controls.RESULTS: In both groups median age was 53 years (p5,p95: 42,67) and 59.6% were men. Median duration of diabetes in the T1DM group was 35 years (p5,p95: 17,49). Median coronary calcium score was higher in T1DM patients (51 vs. 2, p=0.037) compared with controls. However, a similar frequency of >50% stenosis in one or more coronary arteries was found in T1DM patients and controls (18% vs. 14%, p=0.49). LV myocardial perfusion at rest (MyoAD-ratio) was 18% higher in T1DM patients than controls (0.13 vs. 0.11, p<0.0001). This difference was noted throughout all the LV myocardial segments. In a multiple regression analysis including diabetes, sex, age, cardiovascular risk factors, heart rate, calcium score and coronary stenosis >50%, MyoAD-ratio remained significantly higher in T1DM patients (p=0.0001).CONCLUSIONS: LV myocardial perfusion at rest is higher in T1DM patients compared with controls independent of coronary atherosclerosis and cardiovascular risk factors.

AB - AIM: Type 1 diabetes mellitus (T1DM) is associated with an increased risk of ischemic heart disease (IHD). The relative contribution of structural and functional abnormalities of the coronary circulation determining clinically manifested IHD remains unknown. The aim of this study was to assess potential differences in myocardial perfusion at rest and coronary atherosclerosis between asymptomatic T1DM patients and healthy controls.METHODS: Left ventricular (LV) myocardial perfusion at rest measured as LV myocardial Attenuation Density/LV blood pool Attenuation Density (MyoAD-ratio) and coronary artery atherosclerosis were evaluated with 320-multidetector computed tomography angiography in 57 asymptomatic T1DM patients and 114 sex and age matched controls.RESULTS: In both groups median age was 53 years (p5,p95: 42,67) and 59.6% were men. Median duration of diabetes in the T1DM group was 35 years (p5,p95: 17,49). Median coronary calcium score was higher in T1DM patients (51 vs. 2, p=0.037) compared with controls. However, a similar frequency of >50% stenosis in one or more coronary arteries was found in T1DM patients and controls (18% vs. 14%, p=0.49). LV myocardial perfusion at rest (MyoAD-ratio) was 18% higher in T1DM patients than controls (0.13 vs. 0.11, p<0.0001). This difference was noted throughout all the LV myocardial segments. In a multiple regression analysis including diabetes, sex, age, cardiovascular risk factors, heart rate, calcium score and coronary stenosis >50%, MyoAD-ratio remained significantly higher in T1DM patients (p=0.0001).CONCLUSIONS: LV myocardial perfusion at rest is higher in T1DM patients compared with controls independent of coronary atherosclerosis and cardiovascular risk factors.

KW - Adult

KW - Aged

KW - Case-Control Studies

KW - Diabetes Mellitus, Type 1

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Myocardial Ischemia

KW - Risk Factors

KW - Tomography, X-Ray Computed

U2 - 10.1016/j.diabres.2014.10.011

DO - 10.1016/j.diabres.2014.10.011

M3 - Journal article

C2 - 25467625

SN - 0168-8227

VL - 107

SP - 15

EP - 22

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

IS - 1

ER -

Myocardial perfusion at rest in patients with Diabetes Mellitus Type 1 compared with healthy controls assessed with Multi Detector Computed Tomography

Abstract

Keywords

UN SDGs

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