Mutations in the AXIN1 gene in advanced prostate cancer

TY - JOUR

T1 - Mutations in the AXIN1 gene in advanced prostate cancer

AU - Yardy, George W

AU - Bicknell, David C

AU - Wilding, Jennifer L

AU - Bartlett, Sylvia

AU - Liu, Ying

AU - Winney, Bruce

AU - Turner, Gareth D H

AU - Brewster, Simon F

AU - Bodmer, Walter F

PY - 2009/9/1

Y1 - 2009/9/1

N2 - The Wnt signalling pathway directs aspects of embryogenesis and is thought to contribute to maintenance of certain stem cell populations. Disruption of the pathway has been observed in many different tumour types. In bowel, stomach, and endometrial cancer, this is usually due to mutation of genes encoding Wnt pathway components APC or beta-catenin. Such mutations are rare in hepatocellular carcinomas and medulloblastomas with Wnt pathway dysfunction, and there, mutation in genes for other Wnt molecules, such as Axin, is more frequently found.

AB - The Wnt signalling pathway directs aspects of embryogenesis and is thought to contribute to maintenance of certain stem cell populations. Disruption of the pathway has been observed in many different tumour types. In bowel, stomach, and endometrial cancer, this is usually due to mutation of genes encoding Wnt pathway components APC or beta-catenin. Such mutations are rare in hepatocellular carcinomas and medulloblastomas with Wnt pathway dysfunction, and there, mutation in genes for other Wnt molecules, such as Axin, is more frequently found.

KW - Aged

KW - Aged, 80 and over

KW - Genes, APC

KW - Humans

KW - Male

KW - Middle Aged

KW - Mutation

KW - Prostatic Neoplasms

KW - Repressor Proteins

KW - Signal Transduction

KW - Wnt Proteins

KW - beta Catenin

U2 - 10.1016/j.eururo.2008.05.029

DO - 10.1016/j.eururo.2008.05.029

M3 - Journal article

C2 - 18514389

SN - 1569-9056

VL - 56

SP - 486

EP - 494

JO - European Urology, Supplements

JF - European Urology, Supplements

IS - 3

ER -