Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity

T Gylvin; R Nolsøe; T Hansen; E M D Nielsen; R Bergholdt; A E Karlsen; N Billestrup; K Borch-Johnsen; O Pedersen; Thomas Mandrup-Poulsen; J Nerup; F Pociot

doi:10.1007/s00125-004-1440-5

Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity

T Gylvin, R Nolsøe, T Hansen, E M D Nielsen, R Bergholdt, A E Karlsen, N Billestrup, K Borch-Johnsen, O Pedersen, Thomas Mandrup-Poulsen, J Nerup, F Pociot

24 Citations (Scopus)

Abstract

Beta cell loss in Type 1 and Type 2 diabetes mellitus may result from apoptosis and necrosis induced by inflammatory mediators. The suppressor of cytokine signalling (SOCS)-3 is a natural inhibitor of cytokine signalling and also influences insulin signalling. SOCS3 could therefore be a candidate gene in the development of Type 1 and Type 2 diabetes mellitus.

Original language	English
Journal	Diabetologia
Volume	47
Issue number	7
Pages (from-to)	1273-7
Number of pages	5
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s00125-004-1440-5
Publication status	Published - 1 Jul 2004

Keywords

Adolescent
Adult
Base Sequence
Child
Child, Preschool
DNA Mutational Analysis
DNA Primers
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Family
Humans
Infant
Insulin
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Repressor Proteins
Signal Transduction
Suppressor of Cytokine Signaling Proteins
Transcription Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00125-004-1440-5

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Gylvin, T., Nolsøe, R., Hansen, T., Nielsen, E. M. D., Bergholdt, R., Karlsen, A. E., Billestrup, N., Borch-Johnsen, K., Pedersen, O., Mandrup-Poulsen, T., Nerup, J., & Pociot, F. (2004). Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity. Diabetologia, 47(7), 1273-7. https://doi.org/10.1007/s00125-004-1440-5

Gylvin, T, Nolsøe, R, Hansen, T, Nielsen, EMD, Bergholdt, R, Karlsen, AE , Billestrup, N, Borch-Johnsen, K, Pedersen, O, Mandrup-Poulsen, T, Nerup, J & Pociot, F 2004, 'Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity', Diabetologia, vol. 47, no. 7, pp. 1273-7. https://doi.org/10.1007/s00125-004-1440-5

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abstract = "Beta cell loss in Type 1 and Type 2 diabetes mellitus may result from apoptosis and necrosis induced by inflammatory mediators. The suppressor of cytokine signalling (SOCS)-3 is a natural inhibitor of cytokine signalling and also influences insulin signalling. SOCS3 could therefore be a candidate gene in the development of Type 1 and Type 2 diabetes mellitus.",

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AU - Gylvin, T

AU - Nolsøe, R

AU - Hansen, T

AU - Nielsen, E M D

AU - Bergholdt, R

AU - Karlsen, A E

AU - Billestrup, N

AU - Borch-Johnsen, K

AU - Pedersen, O

AU - Mandrup-Poulsen, Thomas

AU - Nerup, J

AU - Pociot, F

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N2 - Beta cell loss in Type 1 and Type 2 diabetes mellitus may result from apoptosis and necrosis induced by inflammatory mediators. The suppressor of cytokine signalling (SOCS)-3 is a natural inhibitor of cytokine signalling and also influences insulin signalling. SOCS3 could therefore be a candidate gene in the development of Type 1 and Type 2 diabetes mellitus.

AB - Beta cell loss in Type 1 and Type 2 diabetes mellitus may result from apoptosis and necrosis induced by inflammatory mediators. The suppressor of cytokine signalling (SOCS)-3 is a natural inhibitor of cytokine signalling and also influences insulin signalling. SOCS3 could therefore be a candidate gene in the development of Type 1 and Type 2 diabetes mellitus.

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KW - Base Sequence

KW - Child

KW - Child, Preschool

KW - DNA Mutational Analysis

KW - DNA Primers

KW - Diabetes Mellitus, Type 1

KW - Diabetes Mellitus, Type 2

KW - Family

KW - Humans

KW - Infant

KW - Insulin

KW - Polymerase Chain Reaction

KW - Polymorphism, Single Nucleotide

KW - Repressor Proteins

KW - Signal Transduction

KW - Suppressor of Cytokine Signaling Proteins

KW - Transcription Factors

U2 - 10.1007/s00125-004-1440-5

DO - 10.1007/s00125-004-1440-5

M3 - Journal article

C2 - 15249995

SN - 0012-186X

VL - 47

SP - 1273

EP - 1277

JO - Diabetologia

JF - Diabetologia

IS - 7

ER -

Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity

Abstract

Keywords

UN SDGs

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