Muscle damage, inflammatory, immune and performance responses to three football games in 1 week in competitive male players

Magni Mohr; Dimitrios Draganidis; Athanasios Chatzinikolaou; Jose Carlos Barbero-Álvarez; Carlo Castagna; Ioannis Douroudos; Alexandra Avloniti; Alexandra Margeli; Ioannis Papassotiriou; Andreas D Flouris; Athanasios Z Jamurtas; Peter Krustrup; Ioannis G Fatouros

doi:10.1007/s00421-015-3245-2

Muscle damage, inflammatory, immune and performance responses to three football games in 1 week in competitive male players

Magni Mohr, Dimitrios Draganidis, Athanasios Chatzinikolaou, Jose Carlos Barbero-Álvarez, Carlo Castagna, Ioannis Douroudos, Alexandra Avloniti, Alexandra Margeli, Ioannis Papassotiriou, Andreas D Flouris, Athanasios Z Jamurtas, Peter Krustrup, Ioannis G Fatouros

The August Krogh Section for Human Physiology

96 Citations (Scopus)

Abstract

PURPOSE: We examined effects of a three-game, 1-week microcycle (G1, G2, G3) on recovery of performance and inflammatory responses in professional male footballers.

METHODS: Players were randomized into an experimental (EXP; N = 20) and a control group (CON; N = 20). Blood was drawn and repeated sprint ability (RSA), muscle soreness and knee range of motion (KJRM) were determined pre- and post-games and during recovery.

RESULTS: High-intensity running during G2 was 7-14 % less compared to G1 and G3. RSA declined in EXP by 2-9 % 3 days post-game with G2 causing the greatest performance impairment. In EXP, game play increased muscle soreness (~sevenfold) compared to CON with G2 inducing the greatest rise, while KJRM was attenuated post-game in EXP compared to CON (5-7 %) and recovered slower post G2 and G3 than G1. CK, CRP, sVCAM-1, sP-Selectin and cortisol peaked 48 h post-games with G2 eliciting the greatest increase. Leukocyte count, testosterone, IL-1β and IL6 responses, although altered 24 h post each game, were comparable among games. Plasma TBARS and protein carbonyls rose by ~50 % post-games with G2 eliciting the greatest increase 48 h of recovery. Reduced to oxidized glutathione ratio declined for 24 h post all games with G2 displaying the slowest recovery. Total antioxidant capacity and glutathione peroxidase activity increased (9-56 %) for 48 h in response to game play.

CONCLUSION: In summary, post-game performance recovery and inflammatory adaptations in response to a three-game weekly microcycle displayed a different response pattern, with strong indications of a largest physiological stress and fatigue after the middle game that was preceded by only a 3-day recovery.

Original language	English
Journal	European Journal of Applied Physiology
Volume	116
Issue number	1
Pages (from-to)	179-193
Number of pages	15
ISSN	1439-6319
DOIs	https://doi.org/10.1007/s00421-015-3245-2
Publication status	Published - 1 Jan 2016

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Mohr, M., Draganidis, D., Chatzinikolaou, A., Barbero-Álvarez, J. C., Castagna, C., Douroudos, I., Avloniti, A., Margeli, A., Papassotiriou, I., Flouris, A. D., Jamurtas, A. Z., Krustrup, P., & Fatouros, I. G. (2016). Muscle damage, inflammatory, immune and performance responses to three football games in 1 week in competitive male players. European Journal of Applied Physiology, 116(1), 179-193. https://doi.org/10.1007/s00421-015-3245-2

Muscle damage, inflammatory, immune and performance responses to three football games in 1 week in competitive male players. / Mohr, Magni; Draganidis, Dimitrios; Chatzinikolaou, Athanasios et al.

In: European Journal of Applied Physiology, Vol. 116, No. 1, 01.01.2016, p. 179-193.

Research output: Contribution to journal › Journal article › Research › peer-review

Mohr, M, Draganidis, D, Chatzinikolaou, A, Barbero-Álvarez, JC, Castagna, C, Douroudos, I, Avloniti, A, Margeli, A, Papassotiriou, I, Flouris, AD, Jamurtas, AZ, Krustrup, P & Fatouros, IG 2016, 'Muscle damage, inflammatory, immune and performance responses to three football games in 1 week in competitive male players', European Journal of Applied Physiology, vol. 116, no. 1, pp. 179-193. https://doi.org/10.1007/s00421-015-3245-2

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abstract = "PURPOSE: We examined effects of a three-game, 1-week microcycle (G1, G2, G3) on recovery of performance and inflammatory responses in professional male footballers.METHODS: Players were randomized into an experimental (EXP; N = 20) and a control group (CON; N = 20). Blood was drawn and repeated sprint ability (RSA), muscle soreness and knee range of motion (KJRM) were determined pre- and post-games and during recovery.RESULTS: High-intensity running during G2 was 7-14 % less compared to G1 and G3. RSA declined in EXP by 2-9 % 3 days post-game with G2 causing the greatest performance impairment. In EXP, game play increased muscle soreness (~sevenfold) compared to CON with G2 inducing the greatest rise, while KJRM was attenuated post-game in EXP compared to CON (5-7 %) and recovered slower post G2 and G3 than G1. CK, CRP, sVCAM-1, sP-Selectin and cortisol peaked 48 h post-games with G2 eliciting the greatest increase. Leukocyte count, testosterone, IL-1β and IL6 responses, although altered 24 h post each game, were comparable among games. Plasma TBARS and protein carbonyls rose by ~50 % post-games with G2 eliciting the greatest increase 48 h of recovery. Reduced to oxidized glutathione ratio declined for 24 h post all games with G2 displaying the slowest recovery. Total antioxidant capacity and glutathione peroxidase activity increased (9-56 %) for 48 h in response to game play.CONCLUSION: In summary, post-game performance recovery and inflammatory adaptations in response to a three-game weekly microcycle displayed a different response pattern, with strong indications of a largest physiological stress and fatigue after the middle game that was preceded by only a 3-day recovery.",

author = "Magni Mohr and Dimitrios Draganidis and Athanasios Chatzinikolaou and Barbero-{\'A}lvarez, {Jose Carlos} and Carlo Castagna and Ioannis Douroudos and Alexandra Avloniti and Alexandra Margeli and Ioannis Papassotiriou and Flouris, {Andreas D} and Jamurtas, {Athanasios Z} and Peter Krustrup and Fatouros, {Ioannis G}",

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AU - Mohr, Magni

AU - Draganidis, Dimitrios

AU - Chatzinikolaou, Athanasios

AU - Barbero-Álvarez, Jose Carlos

AU - Castagna, Carlo

AU - Douroudos, Ioannis

AU - Avloniti, Alexandra

AU - Margeli, Alexandra

AU - Papassotiriou, Ioannis

AU - Flouris, Andreas D

AU - Jamurtas, Athanasios Z

AU - Krustrup, Peter

AU - Fatouros, Ioannis G

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N2 - PURPOSE: We examined effects of a three-game, 1-week microcycle (G1, G2, G3) on recovery of performance and inflammatory responses in professional male footballers.METHODS: Players were randomized into an experimental (EXP; N = 20) and a control group (CON; N = 20). Blood was drawn and repeated sprint ability (RSA), muscle soreness and knee range of motion (KJRM) were determined pre- and post-games and during recovery.RESULTS: High-intensity running during G2 was 7-14 % less compared to G1 and G3. RSA declined in EXP by 2-9 % 3 days post-game with G2 causing the greatest performance impairment. In EXP, game play increased muscle soreness (~sevenfold) compared to CON with G2 inducing the greatest rise, while KJRM was attenuated post-game in EXP compared to CON (5-7 %) and recovered slower post G2 and G3 than G1. CK, CRP, sVCAM-1, sP-Selectin and cortisol peaked 48 h post-games with G2 eliciting the greatest increase. Leukocyte count, testosterone, IL-1β and IL6 responses, although altered 24 h post each game, were comparable among games. Plasma TBARS and protein carbonyls rose by ~50 % post-games with G2 eliciting the greatest increase 48 h of recovery. Reduced to oxidized glutathione ratio declined for 24 h post all games with G2 displaying the slowest recovery. Total antioxidant capacity and glutathione peroxidase activity increased (9-56 %) for 48 h in response to game play.CONCLUSION: In summary, post-game performance recovery and inflammatory adaptations in response to a three-game weekly microcycle displayed a different response pattern, with strong indications of a largest physiological stress and fatigue after the middle game that was preceded by only a 3-day recovery.

AB - PURPOSE: We examined effects of a three-game, 1-week microcycle (G1, G2, G3) on recovery of performance and inflammatory responses in professional male footballers.METHODS: Players were randomized into an experimental (EXP; N = 20) and a control group (CON; N = 20). Blood was drawn and repeated sprint ability (RSA), muscle soreness and knee range of motion (KJRM) were determined pre- and post-games and during recovery.RESULTS: High-intensity running during G2 was 7-14 % less compared to G1 and G3. RSA declined in EXP by 2-9 % 3 days post-game with G2 causing the greatest performance impairment. In EXP, game play increased muscle soreness (~sevenfold) compared to CON with G2 inducing the greatest rise, while KJRM was attenuated post-game in EXP compared to CON (5-7 %) and recovered slower post G2 and G3 than G1. CK, CRP, sVCAM-1, sP-Selectin and cortisol peaked 48 h post-games with G2 eliciting the greatest increase. Leukocyte count, testosterone, IL-1β and IL6 responses, although altered 24 h post each game, were comparable among games. Plasma TBARS and protein carbonyls rose by ~50 % post-games with G2 eliciting the greatest increase 48 h of recovery. Reduced to oxidized glutathione ratio declined for 24 h post all games with G2 displaying the slowest recovery. Total antioxidant capacity and glutathione peroxidase activity increased (9-56 %) for 48 h in response to game play.CONCLUSION: In summary, post-game performance recovery and inflammatory adaptations in response to a three-game weekly microcycle displayed a different response pattern, with strong indications of a largest physiological stress and fatigue after the middle game that was preceded by only a 3-day recovery.

U2 - 10.1007/s00421-015-3245-2

DO - 10.1007/s00421-015-3245-2

M3 - Journal article

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SN - 1439-6319

VL - 116

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EP - 193

JO - European Journal of Applied Physiology

JF - European Journal of Applied Physiology

IS - 1

ER -

Muscle damage, inflammatory, immune and performance responses to three football games in 1 week in competitive male players

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