Multiple sclerosis and polymorphisms of innate pattern recognition receptors TLR1-10, NOD1-2, DDX58, and IFIH1

Christian Enevold; Annette Bang Oturai; Per Soelberg Sørensen; Lars Peter Ryder; Nils Koch-Henriksen; Klaus Bendtzen

doi:10.1016/j.jneuroim.2009.04.008

Multiple sclerosis and polymorphisms of innate pattern recognition receptors TLR1-10, NOD1-2, DDX58, and IFIH1

Christian Enevold, Annette Bang Oturai, Per Soelberg Sørensen, Lars Peter Ryder, Nils Koch-Henriksen, Klaus Bendtzen

Department of Clinical Medicine

46 Citations (Scopus)

Abstract

Genetic factors are critical in multiple sclerosis (MS), and it is conceivable that the pattern recognition receptors of the innate immune system are of pathogenic importance. We therefore developed two novel assays capable of analyzing 42 single-nucleotide polymorphisms in the human genes encoding TLR1-10, NOD1-2, DDX58, and IFIH1. Using these assays, we genotyped 963 MS patients and 960 controls, and analyzed for possible associations to MS diagnosis, clinical course, severity, and age at onset. Our results support previous findings of associations between the IFIH1-locus and MS (IFIH1-rs3747517 and IFIH1-rs1990760 trend test: P=0.002 and P=0.014, respectively).

Original language	English
Journal	Journal of Neuroimmunology
Volume	212
Issue number	1-2
Pages (from-to)	125-31
Number of pages	7
ISSN	0165-5728
DOIs	https://doi.org/10.1016/j.jneuroim.2009.04.008 https://doi.org/10.1016/j.jneuroim.2009.04.008
Publication status	Published - 25 Jul 2009

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title = "Multiple sclerosis and polymorphisms of innate pattern recognition receptors TLR1-10, NOD1-2, DDX58, and IFIH1",

abstract = "Genetic factors are critical in multiple sclerosis (MS), and it is conceivable that the pattern recognition receptors of the innate immune system are of pathogenic importance. We therefore developed two novel assays capable of analyzing 42 single-nucleotide polymorphisms in the human genes encoding TLR1-10, NOD1-2, DDX58, and IFIH1. Using these assays, we genotyped 963 MS patients and 960 controls, and analyzed for possible associations to MS diagnosis, clinical course, severity, and age at onset. Our results support previous findings of associations between the IFIH1-locus and MS (IFIH1-rs3747517 and IFIH1-rs1990760 trend test: P=0.002 and P=0.014, respectively).",

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T1 - Multiple sclerosis and polymorphisms of innate pattern recognition receptors TLR1-10, NOD1-2, DDX58, and IFIH1

AU - Enevold, Christian

AU - Oturai, Annette Bang

AU - Sørensen, Per Soelberg

AU - Ryder, Lars Peter

AU - Koch-Henriksen, Nils

AU - Bendtzen, Klaus

PY - 2009/7/25

Y1 - 2009/7/25

N2 - Genetic factors are critical in multiple sclerosis (MS), and it is conceivable that the pattern recognition receptors of the innate immune system are of pathogenic importance. We therefore developed two novel assays capable of analyzing 42 single-nucleotide polymorphisms in the human genes encoding TLR1-10, NOD1-2, DDX58, and IFIH1. Using these assays, we genotyped 963 MS patients and 960 controls, and analyzed for possible associations to MS diagnosis, clinical course, severity, and age at onset. Our results support previous findings of associations between the IFIH1-locus and MS (IFIH1-rs3747517 and IFIH1-rs1990760 trend test: P=0.002 and P=0.014, respectively).

AB - Genetic factors are critical in multiple sclerosis (MS), and it is conceivable that the pattern recognition receptors of the innate immune system are of pathogenic importance. We therefore developed two novel assays capable of analyzing 42 single-nucleotide polymorphisms in the human genes encoding TLR1-10, NOD1-2, DDX58, and IFIH1. Using these assays, we genotyped 963 MS patients and 960 controls, and analyzed for possible associations to MS diagnosis, clinical course, severity, and age at onset. Our results support previous findings of associations between the IFIH1-locus and MS (IFIH1-rs3747517 and IFIH1-rs1990760 trend test: P=0.002 and P=0.014, respectively).

U2 - 10.1016/j.jneuroim.2009.04.008

DO - 10.1016/j.jneuroim.2009.04.008

M3 - Journal article

C2 - 19450885

SN - 0165-5728

VL - 212

SP - 125

EP - 131

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Multiple sclerosis and polymorphisms of innate pattern recognition receptors TLR1-10, NOD1-2, DDX58, and IFIH1

Abstract

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