Multiple loci with different cancer specificities within the 8q24 gene desert

M. Ghoussaini; H. Song; T. Koessler; A.A. Al Olama; Z. Kote-Jarai; K.E. Driver; K.A. Pooley; S.J. Ramus; E. Hogdall; R.A. DiCioccio; A.S. Whittemore; S.A. Gayther; G.G. Giles; M. Guy; S.M. Edwards; J. Morrison; J.L. Donovan; F.C. Hamdy; D.P. Dearnaley; A.T. Ardern-Jones; A.L. Hall; L.T. O'Brien; B.N. Gehr-Swain; R.A. Wilkinson; P.M. Brown; J.L. Hopper; D.E. Neal; P.D. Pharoah; B.A. Ponder; R.A. Eeles; D.F. Easton; A.M. Dunning; Susanne Krüger Kjær

Multiple loci with different cancer specificities within the 8q24 gene desert

M. Ghoussaini, H. Song, T. Koessler, A.A. Al Olama, Z. Kote-Jarai, K.E. Driver, K.A. Pooley, S.J. Ramus, E. Hogdall, R.A. DiCioccio, A.S. Whittemore, S.A. Gayther, G.G. Giles, M. Guy, S.M. Edwards, J. Morrison, J.L. Donovan, F.C. Hamdy, D.P. Dearnaley, A.T. Ardern-JonesA.L. Hall, L.T. O'Brien, B.N. Gehr-Swain, R.A. Wilkinson, P.M. Brown, J.L. Hopper, D.E. Neal, P.D. Pharoah, B.A. Ponder, R.A. Eeles, D.F. Easton, A.M. Dunning, Susanne Krüger Kjær

Undervisning - FSV

272 Citations (Scopus)

Abstract

Recent studies based on genome-wide association, linkage, and admixture scan analysis have reported associations of various genetic variants in 8q24 with susceptibility to breast, prostate, and colorectal cancer. This locus lies within a 1.18-Mb region that contains no known genes but is bounded at its centromeric end by FAM84B and at its telomeric end by c-MYC, two candidate cancer susceptibility genes. To investigate the associations of specific loci within 8q24 with specific cancers, we genotyped the nine previously reported cancer-associated single-nucleotide polymorphisms across the region in four case-control sets of prostate (1854 case subjects and 1894 control subjects), breast (2270 case subjects and 2280 control subjects), colorectal (2299 case subjects and 2284 control subjects), and ovarian (1975 case subjects and 3411 control subjects) cancer. Five different haplotype blocks within this gene desert were specifically associated with risks of different cancers. One block was solely associated with risk of breast cancer, three others were associated solely with the risk of prostate cancer, and a fifth was associated with the risk of prostate, colorectal, and ovarian cancer, but not breast cancer. We conclude that there are at least five separate functional variants in this region
Udgivelsesdato: 2008/7/2

Original language	English
Journal	JNCI - Journal of the National Cancer Institute
Volume	100
Issue number	13
Pages (from-to)	962-966
Number of pages	4
ISSN	0027-8874
Publication status	Published - 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

Ghoussaini, M., Song, H., Koessler, T., Olama, A. A. A., Kote-Jarai, Z., Driver, K. E., Pooley, K. A., Ramus, S. J., Hogdall, E., DiCioccio, R. A., Whittemore, A. S., Gayther, S. A., Giles, G. G., Guy, M., Edwards, S. M., Morrison, J., Donovan, J. L., Hamdy, F. C., Dearnaley, D. P., ... Kjær, S. K. (2008). Multiple loci with different cancer specificities within the 8q24 gene desert. JNCI - Journal of the National Cancer Institute, 100(13), 962-966.

Ghoussaini, M, Song, H, Koessler, T, Olama, AAA, Kote-Jarai, Z, Driver, KE, Pooley, KA, Ramus, SJ, Hogdall, E, DiCioccio, RA, Whittemore, AS, Gayther, SA, Giles, GG, Guy, M, Edwards, SM, Morrison, J, Donovan, JL, Hamdy, FC, Dearnaley, DP, Ardern-Jones, AT, Hall, AL, O'Brien, LT, Gehr-Swain, BN, Wilkinson, RA, Brown, PM, Hopper, JL, Neal, DE, Pharoah, PD, Ponder, BA, Eeles, RA, Easton, DF, Dunning, AM & Kjær, SK 2008, 'Multiple loci with different cancer specificities within the 8q24 gene desert', JNCI - Journal of the National Cancer Institute, vol. 100, no. 13, pp. 962-966.

@article{b9549ad08c9c11de8bc9000ea68e967b,

title = "Multiple loci with different cancer specificities within the 8q24 gene desert",

abstract = "Recent studies based on genome-wide association, linkage, and admixture scan analysis have reported associations of various genetic variants in 8q24 with susceptibility to breast, prostate, and colorectal cancer. This locus lies within a 1.18-Mb region that contains no known genes but is bounded at its centromeric end by FAM84B and at its telomeric end by c-MYC, two candidate cancer susceptibility genes. To investigate the associations of specific loci within 8q24 with specific cancers, we genotyped the nine previously reported cancer-associated single-nucleotide polymorphisms across the region in four case-control sets of prostate (1854 case subjects and 1894 control subjects), breast (2270 case subjects and 2280 control subjects), colorectal (2299 case subjects and 2284 control subjects), and ovarian (1975 case subjects and 3411 control subjects) cancer. Five different haplotype blocks within this gene desert were specifically associated with risks of different cancers. One block was solely associated with risk of breast cancer, three others were associated solely with the risk of prostate cancer, and a fifth was associated with the risk of prostate, colorectal, and ovarian cancer, but not breast cancer. We conclude that there are at least five separate functional variants in this region Udgivelsesdato: 2008/7/2",

author = "M. Ghoussaini and H. Song and T. Koessler and Olama, {A.A. Al} and Z. Kote-Jarai and K.E. Driver and K.A. Pooley and S.J. Ramus and E. Hogdall and R.A. DiCioccio and A.S. Whittemore and S.A. Gayther and G.G. Giles and M. Guy and S.M. Edwards and J. Morrison and J.L. Donovan and F.C. Hamdy and D.P. Dearnaley and A.T. Ardern-Jones and A.L. Hall and L.T. O'Brien and B.N. Gehr-Swain and R.A. Wilkinson and P.M. Brown and J.L. Hopper and D.E. Neal and P.D. Pharoah and B.A. Ponder and R.A. Eeles and D.F. Easton and A.M. Dunning and Kj{\ae}r, {Susanne Kr{\"u}ger}",

note = "IS - 1460-2105 (Electronic)LA - engPT - Journal ArticlePT - Research Support, N.I.H., ExtramuralPT - Research Support, Non-U.S. Gov'tSB - IM",

year = "2008",

language = "English",

volume = "100",

pages = "962--966",

journal = "National Cancer Institute. Journal (Print)",

issn = "0027-8874",

publisher = "Oxford University Press",

number = "13",

}

TY - JOUR

T1 - Multiple loci with different cancer specificities within the 8q24 gene desert

AU - Ghoussaini, M.

AU - Song, H.

AU - Koessler, T.

AU - Olama, A.A. Al

AU - Kote-Jarai, Z.

AU - Driver, K.E.

AU - Pooley, K.A.

AU - Ramus, S.J.

AU - Hogdall, E.

AU - DiCioccio, R.A.

AU - Whittemore, A.S.

AU - Gayther, S.A.

AU - Giles, G.G.

AU - Guy, M.

AU - Edwards, S.M.

AU - Morrison, J.

AU - Donovan, J.L.

AU - Hamdy, F.C.

AU - Dearnaley, D.P.

AU - Ardern-Jones, A.T.

AU - Hall, A.L.

AU - O'Brien, L.T.

AU - Gehr-Swain, B.N.

AU - Wilkinson, R.A.

AU - Brown, P.M.

AU - Hopper, J.L.

AU - Neal, D.E.

AU - Pharoah, P.D.

AU - Ponder, B.A.

AU - Eeles, R.A.

AU - Easton, D.F.

AU - Dunning, A.M.

AU - Kjær, Susanne Krüger

N1 - IS - 1460-2105 (Electronic)LA - engPT - Journal ArticlePT - Research Support, N.I.H., ExtramuralPT - Research Support, Non-U.S. Gov'tSB - IM

PY - 2008

Y1 - 2008

N2 - Recent studies based on genome-wide association, linkage, and admixture scan analysis have reported associations of various genetic variants in 8q24 with susceptibility to breast, prostate, and colorectal cancer. This locus lies within a 1.18-Mb region that contains no known genes but is bounded at its centromeric end by FAM84B and at its telomeric end by c-MYC, two candidate cancer susceptibility genes. To investigate the associations of specific loci within 8q24 with specific cancers, we genotyped the nine previously reported cancer-associated single-nucleotide polymorphisms across the region in four case-control sets of prostate (1854 case subjects and 1894 control subjects), breast (2270 case subjects and 2280 control subjects), colorectal (2299 case subjects and 2284 control subjects), and ovarian (1975 case subjects and 3411 control subjects) cancer. Five different haplotype blocks within this gene desert were specifically associated with risks of different cancers. One block was solely associated with risk of breast cancer, three others were associated solely with the risk of prostate cancer, and a fifth was associated with the risk of prostate, colorectal, and ovarian cancer, but not breast cancer. We conclude that there are at least five separate functional variants in this region Udgivelsesdato: 2008/7/2

AB - Recent studies based on genome-wide association, linkage, and admixture scan analysis have reported associations of various genetic variants in 8q24 with susceptibility to breast, prostate, and colorectal cancer. This locus lies within a 1.18-Mb region that contains no known genes but is bounded at its centromeric end by FAM84B and at its telomeric end by c-MYC, two candidate cancer susceptibility genes. To investigate the associations of specific loci within 8q24 with specific cancers, we genotyped the nine previously reported cancer-associated single-nucleotide polymorphisms across the region in four case-control sets of prostate (1854 case subjects and 1894 control subjects), breast (2270 case subjects and 2280 control subjects), colorectal (2299 case subjects and 2284 control subjects), and ovarian (1975 case subjects and 3411 control subjects) cancer. Five different haplotype blocks within this gene desert were specifically associated with risks of different cancers. One block was solely associated with risk of breast cancer, three others were associated solely with the risk of prostate cancer, and a fifth was associated with the risk of prostate, colorectal, and ovarian cancer, but not breast cancer. We conclude that there are at least five separate functional variants in this region Udgivelsesdato: 2008/7/2

M3 - Journal article

SN - 0027-8874

VL - 100

SP - 962

EP - 966

JO - National Cancer Institute. Journal (Print)

JF - National Cancer Institute. Journal (Print)

IS - 13

ER -