Multinational evidence-based recommendations for pain management by pharmacotherapy in inflammatory arthritis: integrating systematic literature research and expert opinion of a broad panel of rheumatologists in the 3e Initiative

Samuel L Whittle; Alexandra N Colebatch; Rachelle Buchbinder; Christopher J Edwards; Karen Adams; Matthias Englbrecht; Glen Hazlewood; Jonathan L Marks; Helga Radner; Sofia Ramiro; Bethan L Richards; Ingo H Tarner; Daniel Aletaha; Claire Bombardier; Robert B Landewé; Ulf Müller-Ladner; Johannes W J Bijlsma; Jaime C Branco; Vivian P Bykerk; Geraldo da Rocha Castelar Pinheiro; Anca I Catrina; Pekka Hannonen; Patrick Kiely; Burkhard Leeb; Elisabeth Lie; Píndaro Martinez-Osuna; Carlomaurizio Montecucco; Mikkel Østergaard; Rene Westhovens; Jane Zochling; Désirée van der Heijde

doi:10.1093/rheumatology/kes032

Multinational evidence-based recommendations for pain management by pharmacotherapy in inflammatory arthritis: integrating systematic literature research and expert opinion of a broad panel of rheumatologists in the 3e Initiative

Samuel L Whittle, Alexandra N Colebatch, Rachelle Buchbinder, Christopher J Edwards, Karen Adams, Matthias Englbrecht, Glen Hazlewood, Jonathan L Marks, Helga Radner, Sofia Ramiro, Bethan L Richards, Ingo H Tarner, Daniel Aletaha, Claire Bombardier, Robert B Landewé, Ulf Müller-Ladner, Johannes W J Bijlsma, Jaime C Branco, Vivian P Bykerk, Geraldo da Rocha Castelar PinheiroAnca I Catrina, Pekka Hannonen, Patrick Kiely, Burkhard Leeb, Elisabeth Lie, Píndaro Martinez-Osuna, Carlomaurizio Montecucco, Mikkel Østergaard, Rene Westhovens, Jane Zochling, Désirée van der Heijde

61 Citations (Scopus)

Abstract

Objective. To develop evidence-based recommendations for pain management by pharmacotherapy in patients with inflammatory arthritis (IA).Methods. A total of 453 rheumatologists from 17 countries participated in the 2010 3e (Evidence, Expertise, Exchange) Initiative. Using a formal voting process, 89 rheumatologists representing all 17 countries selected 10 clinical questions regarding the use of pain medications in IA. Bibliographic fellows undertook a systematic literature review for each question, using MEDLINE, EMBASE, Cochrane CENTRAL and 2008-09 European League Against Rheumatism (EULAR)/ACR abstracts. Relevant studies were retrieved for data extraction and quality assessment. Rheumatologists from each country used this evidence to develop a set of national recommendations. Multinational recommendations were then formulated and assessed for agreement and the potential impact on clinical practice.Results. A total of 49¿242 references were identified, from which 167 studies were included in the systematic reviews. One clinical question regarding different comorbidities was divided into two separate reviews, resulting in 11 recommendations in total. Oxford levels of evidence were applied to each recommendation. The recommendations related to the efficacy and safety of various analgesic medications, pain measurement scales and pain management in the pre-conception period, pregnancy and lactation. Finally, an algorithm for the pharmacological management of pain in IA was developed. Twenty per cent of rheumatologists reported that the algorithm would change their practice, and 75% felt the algorithm was in accordance with their current practice.Conclusions. Eleven evidence-based recommendations on the management of pain by pharmacotherapy in IA were developed. They are supported by a large panel of rheumatologists from 17 countries, thus enhancing their utility in clinical practice.

Original language	English
Publication date	Aug 2012
DOIs	https://doi.org/10.1093/rheumatology/kes032
Publication status	Published - Aug 2012

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Whittle, S. L., Colebatch, A. N., Buchbinder, R., Edwards, C. J., Adams, K., Englbrecht, M., Hazlewood, G., Marks, J. L., Radner, H., Ramiro, S., Richards, B. L., Tarner, I. H., Aletaha, D., Bombardier, C., Landewé, R. B., Müller-Ladner, U., Bijlsma, J. W. J., Branco, J. C., Bykerk, V. P., ... van der Heijde, D. (2012, Aug). Multinational evidence-based recommendations for pain management by pharmacotherapy in inflammatory arthritis: integrating systematic literature research and expert opinion of a broad panel of rheumatologists in the 3e Initiative. https://doi.org/10.1093/rheumatology/kes032

Multinational evidence-based recommendations for pain management by pharmacotherapy in inflammatory arthritis : integrating systematic literature research and expert opinion of a broad panel of rheumatologists in the 3e Initiative. / Whittle, Samuel L; Colebatch, Alexandra N; Buchbinder, Rachelle et al.

2012.

Research output: Other contribution › Net publication - Internet publication › Research › peer-review

Whittle, SL, Colebatch, AN, Buchbinder, R, Edwards, CJ, Adams, K, Englbrecht, M, Hazlewood, G, Marks, JL, Radner, H, Ramiro, S, Richards, BL, Tarner, IH, Aletaha, D, Bombardier, C, Landewé, RB, Müller-Ladner, U, Bijlsma, JWJ, Branco, JC, Bykerk, VP, da Rocha Castelar Pinheiro, G, Catrina, AI, Hannonen, P, Kiely, P, Leeb, B, Lie, E, Martinez-Osuna, P, Montecucco, C, Østergaard, M, Westhovens, R, Zochling, J & van der Heijde, D 2012, Multinational evidence-based recommendations for pain management by pharmacotherapy in inflammatory arthritis: integrating systematic literature research and expert opinion of a broad panel of rheumatologists in the 3e Initiative.. https://doi.org/10.1093/rheumatology/kes032

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title = "Multinational evidence-based recommendations for pain management by pharmacotherapy in inflammatory arthritis: integrating systematic literature research and expert opinion of a broad panel of rheumatologists in the 3e Initiative",

abstract = "Objective. To develop evidence-based recommendations for pain management by pharmacotherapy in patients with inflammatory arthritis (IA).Methods. A total of 453 rheumatologists from 17 countries participated in the 2010 3e (Evidence, Expertise, Exchange) Initiative. Using a formal voting process, 89 rheumatologists representing all 17 countries selected 10 clinical questions regarding the use of pain medications in IA. Bibliographic fellows undertook a systematic literature review for each question, using MEDLINE, EMBASE, Cochrane CENTRAL and 2008-09 European League Against Rheumatism (EULAR)/ACR abstracts. Relevant studies were retrieved for data extraction and quality assessment. Rheumatologists from each country used this evidence to develop a set of national recommendations. Multinational recommendations were then formulated and assessed for agreement and the potential impact on clinical practice.Results. A total of 49¿242 references were identified, from which 167 studies were included in the systematic reviews. One clinical question regarding different comorbidities was divided into two separate reviews, resulting in 11 recommendations in total. Oxford levels of evidence were applied to each recommendation. The recommendations related to the efficacy and safety of various analgesic medications, pain measurement scales and pain management in the pre-conception period, pregnancy and lactation. Finally, an algorithm for the pharmacological management of pain in IA was developed. Twenty per cent of rheumatologists reported that the algorithm would change their practice, and 75% felt the algorithm was in accordance with their current practice.Conclusions. Eleven evidence-based recommendations on the management of pain by pharmacotherapy in IA were developed. They are supported by a large panel of rheumatologists from 17 countries, thus enhancing their utility in clinical practice.",

author = "Whittle, {Samuel L} and Colebatch, {Alexandra N} and Rachelle Buchbinder and Edwards, {Christopher J} and Karen Adams and Matthias Englbrecht and Glen Hazlewood and Marks, {Jonathan L} and Helga Radner and Sofia Ramiro and Richards, {Bethan L} and Tarner, {Ingo H} and Daniel Aletaha and Claire Bombardier and Landew{\'e}, {Robert B} and Ulf M{\"u}ller-Ladner and Bijlsma, {Johannes W J} and Branco, {Jaime C} and Bykerk, {Vivian P} and {da Rocha Castelar Pinheiro}, Geraldo and Catrina, {Anca I} and Pekka Hannonen and Patrick Kiely and Burkhard Leeb and Elisabeth Lie and P{\'i}ndaro Martinez-Osuna and Carlomaurizio Montecucco and Mikkel {\O}stergaard and Rene Westhovens and Jane Zochling and {van der Heijde}, D{\'e}sir{\'e}e",

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doi = "10.1093/rheumatology/kes032",

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TY - ICOMM

T1 - Multinational evidence-based recommendations for pain management by pharmacotherapy in inflammatory arthritis

T2 - integrating systematic literature research and expert opinion of a broad panel of rheumatologists in the 3e Initiative

AU - Whittle, Samuel L

AU - Colebatch, Alexandra N

AU - Buchbinder, Rachelle

AU - Edwards, Christopher J

AU - Adams, Karen

AU - Englbrecht, Matthias

AU - Hazlewood, Glen

AU - Marks, Jonathan L

AU - Radner, Helga

AU - Ramiro, Sofia

AU - Richards, Bethan L

AU - Tarner, Ingo H

AU - Aletaha, Daniel

AU - Bombardier, Claire

AU - Landewé, Robert B

AU - Müller-Ladner, Ulf

AU - Bijlsma, Johannes W J

AU - Branco, Jaime C

AU - Bykerk, Vivian P

AU - da Rocha Castelar Pinheiro, Geraldo

AU - Catrina, Anca I

AU - Hannonen, Pekka

AU - Kiely, Patrick

AU - Leeb, Burkhard

AU - Lie, Elisabeth

AU - Martinez-Osuna, Píndaro

AU - Montecucco, Carlomaurizio

AU - Østergaard, Mikkel

AU - Westhovens, Rene

AU - Zochling, Jane

AU - van der Heijde, Désirée

N1 - www.rheumatology.oxfordjournals.org

PY - 2012/8

Y1 - 2012/8

N2 - Objective. To develop evidence-based recommendations for pain management by pharmacotherapy in patients with inflammatory arthritis (IA).Methods. A total of 453 rheumatologists from 17 countries participated in the 2010 3e (Evidence, Expertise, Exchange) Initiative. Using a formal voting process, 89 rheumatologists representing all 17 countries selected 10 clinical questions regarding the use of pain medications in IA. Bibliographic fellows undertook a systematic literature review for each question, using MEDLINE, EMBASE, Cochrane CENTRAL and 2008-09 European League Against Rheumatism (EULAR)/ACR abstracts. Relevant studies were retrieved for data extraction and quality assessment. Rheumatologists from each country used this evidence to develop a set of national recommendations. Multinational recommendations were then formulated and assessed for agreement and the potential impact on clinical practice.Results. A total of 49¿242 references were identified, from which 167 studies were included in the systematic reviews. One clinical question regarding different comorbidities was divided into two separate reviews, resulting in 11 recommendations in total. Oxford levels of evidence were applied to each recommendation. The recommendations related to the efficacy and safety of various analgesic medications, pain measurement scales and pain management in the pre-conception period, pregnancy and lactation. Finally, an algorithm for the pharmacological management of pain in IA was developed. Twenty per cent of rheumatologists reported that the algorithm would change their practice, and 75% felt the algorithm was in accordance with their current practice.Conclusions. Eleven evidence-based recommendations on the management of pain by pharmacotherapy in IA were developed. They are supported by a large panel of rheumatologists from 17 countries, thus enhancing their utility in clinical practice.

AB - Objective. To develop evidence-based recommendations for pain management by pharmacotherapy in patients with inflammatory arthritis (IA).Methods. A total of 453 rheumatologists from 17 countries participated in the 2010 3e (Evidence, Expertise, Exchange) Initiative. Using a formal voting process, 89 rheumatologists representing all 17 countries selected 10 clinical questions regarding the use of pain medications in IA. Bibliographic fellows undertook a systematic literature review for each question, using MEDLINE, EMBASE, Cochrane CENTRAL and 2008-09 European League Against Rheumatism (EULAR)/ACR abstracts. Relevant studies were retrieved for data extraction and quality assessment. Rheumatologists from each country used this evidence to develop a set of national recommendations. Multinational recommendations were then formulated and assessed for agreement and the potential impact on clinical practice.Results. A total of 49¿242 references were identified, from which 167 studies were included in the systematic reviews. One clinical question regarding different comorbidities was divided into two separate reviews, resulting in 11 recommendations in total. Oxford levels of evidence were applied to each recommendation. The recommendations related to the efficacy and safety of various analgesic medications, pain measurement scales and pain management in the pre-conception period, pregnancy and lactation. Finally, an algorithm for the pharmacological management of pain in IA was developed. Twenty per cent of rheumatologists reported that the algorithm would change their practice, and 75% felt the algorithm was in accordance with their current practice.Conclusions. Eleven evidence-based recommendations on the management of pain by pharmacotherapy in IA were developed. They are supported by a large panel of rheumatologists from 17 countries, thus enhancing their utility in clinical practice.

U2 - 10.1093/rheumatology/kes032

DO - 10.1093/rheumatology/kes032

M3 - Net publication - Internet publication

C2 - 22447886

ER -