Multifaceted Pharmacist‐led Interventions in the Hospital Setting: A Systematic Review

Helene Skjøt-Arkil; Carina Lundby Olesen; Lene Juel Kjeldsen; Diana Mark Skovsgaards; Anna Birna Almarsdóttir; Tue Kjølhede; Tina Hoff Duedahl; Anton Pottegaard; Trine Graabæk Hansen

doi:10.1111/bcpt.13030

Multifaceted Pharmacist‐led Interventions in the Hospital Setting: A Systematic Review

Helene Skjøt-Arkil, Carina Lundby Olesen, Lene Juel Kjeldsen, Diana Mark Skovsgaards, Anna Birna Almarsdóttir, Tue Kjølhede , Tina Hoff Duedahl, Anton Pottegaard, Trine Graabæk Hansen

16 Citations (Scopus)

Abstract

Clinical pharmacy services often comprise complex interventions. In this MiniReview, we conducted a systematic review aiming to evaluate the impact of multifaceted pharmacist-led interventions in a hospital setting. We searched MEDLINE, Embase, Cochrane Library and CINAHL for peer-reviewed articles published from 2006 to 1 March 2018. Controlled trials concerning hospitalized patients in any setting receiving patient-related multifaceted pharmacist-led interventions were considered. All types of outcome were accepted. Inclusion and data extraction were performed. Study characteristics were collected, and risk of bias assessment was conducted utilizing the Cochrane Risk of Bias tools. All stages were conducted by at least two independent reviewers. The review was registered in PROSPERO (CRD42017075808). A total of 11,896 publications were identified, and 28 publications were included. Of these, 17 were conducted in Europe. Six of the included publications were multi-centre studies, and 16 were randomized trials. Usual care was the comparator. Significant results on quality of medication use were reported as positive in eleven studies (n = 18; 61%) and negative in one (n = 18, 6%). Hospital visits were reduced significantly in seven studies (n = 16; 44%). Four studies (n = 12; 33%) reported a positive significant effect on either length of stay or time to revisit, and one study reported a negative effect (n = 12; 6%). All studies investigating mortality (n = 6), patient-reported outcome (n = 7) and cost-effectiveness (n = 1) showed no significant results. This MiniReview indicates that multifaceted pharmacist-led interventions in a hospital setting may improve the quality of medication use and reduce hospital visits and length of stay, while no effect was seen on mortality, patient-reported outcome and cost-effectiveness.

Original language	English
Journal	Basic & Clinical Pharmacology & Toxicology
Volume	123
Issue number	4
Pages (from-to)	363-379
ISSN	1742-7835
DOIs	https://doi.org/10.1111/bcpt.13030
Publication status	Published - Oct 2018

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title = "Multifaceted Pharmacist‐led Interventions in the Hospital Setting: A Systematic Review",

abstract = "Clinical pharmacy services often comprise complex interventions. In this MiniReview, we conducted a systematic review aiming to evaluate the impact of multifaceted pharmacist-led interventions in a hospital setting. We searched MEDLINE, Embase, Cochrane Library and CINAHL for peer-reviewed articles published from 2006 to 1 March 2018. Controlled trials concerning hospitalized patients in any setting receiving patient-related multifaceted pharmacist-led interventions were considered. All types of outcome were accepted. Inclusion and data extraction were performed. Study characteristics were collected, and risk of bias assessment was conducted utilizing the Cochrane Risk of Bias tools. All stages were conducted by at least two independent reviewers. The review was registered in PROSPERO (CRD42017075808). A total of 11,896 publications were identified, and 28 publications were included. Of these, 17 were conducted in Europe. Six of the included publications were multi-centre studies, and 16 were randomized trials. Usual care was the comparator. Significant results on quality of medication use were reported as positive in eleven studies (n = 18; 61%) and negative in one (n = 18, 6%). Hospital visits were reduced significantly in seven studies (n = 16; 44%). Four studies (n = 12; 33%) reported a positive significant effect on either length of stay or time to revisit, and one study reported a negative effect (n = 12; 6%). All studies investigating mortality (n = 6), patient-reported outcome (n = 7) and cost-effectiveness (n = 1) showed no significant results. This MiniReview indicates that multifaceted pharmacist-led interventions in a hospital setting may improve the quality of medication use and reduce hospital visits and length of stay, while no effect was seen on mortality, patient-reported outcome and cost-effectiveness.",

author = "Helene Skj{\o}t-Arkil and {Lundby Olesen}, Carina and Kjeldsen, {Lene Juel} and Skovsgaards, {Diana Mark} and Almarsd{\'o}ttir, {Anna Birna} and Tue Kj{\o}lhede and Duedahl, {Tina Hoff} and Anton Pottegaard and Hansen, {Trine Graab{\ae}k}",

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AU - Lundby Olesen, Carina

AU - Kjeldsen, Lene Juel

AU - Skovsgaards, Diana Mark

AU - Almarsdóttir, Anna Birna

AU - Kjølhede , Tue

AU - Duedahl, Tina Hoff

AU - Pottegaard, Anton

AU - Hansen, Trine Graabæk

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DO - 10.1111/bcpt.13030

M3 - Review

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JO - Basic & Clinical Pharmacology & Toxicology

JF - Basic & Clinical Pharmacology & Toxicology

IS - 4

ER -

Multifaceted Pharmacist‐led Interventions in the Hospital Setting: A Systematic Review

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