Multidrug-resistantinfection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017

TY - JOUR

T1 - Multidrug-resistantinfection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017

AU - Terkelsen, David

AU - Tolstrup, Jacob

AU - Johnsen, Camilla Hundahl

AU - Lund, Ole

AU - Larsen, Helle Kiellberg

AU - Worning, Peder

AU - Unemo, Magnus

AU - Westh, Henrik

PY - 2017/10/19

Y1 - 2017/10/19

N2 - We describe a multidrug-resistantNeisseria gonorrhoeaeinfection with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Denmark, 2017. Whole genome sequencing of the strain GK124 identified MSLT ST1903, NG-MAST ST1614 and all relevant resistance determinants including similar penA resistance mutations previously described in ceftriaxone-resistant gonococcal strains. Although treatment with ceftriaxone 0.5 g plus azithromycin 2 g was successful, increased awareness of spread of gonococcal strains threatening the recommended dual therapy is crucial.

AB - We describe a multidrug-resistantNeisseria gonorrhoeaeinfection with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Denmark, 2017. Whole genome sequencing of the strain GK124 identified MSLT ST1903, NG-MAST ST1614 and all relevant resistance determinants including similar penA resistance mutations previously described in ceftriaxone-resistant gonococcal strains. Although treatment with ceftriaxone 0.5 g plus azithromycin 2 g was successful, increased awareness of spread of gonococcal strains threatening the recommended dual therapy is crucial.

U2 - 10.2807/1560-7917.ES.2017.22.42.17-00659

DO - 10.2807/1560-7917.ES.2017.22.42.17-00659

M3 - Journal article

C2 - 29067905

SN - 1025-496X

VL - 22

JO - Eurosurveillance

JF - Eurosurveillance

IS - 42

M1 - pii=17-00659

ER -