Multi-frequency bioelectrical impedance analysis (BIA) compared to magnetic resonance imaging (MRI) for estimation of fat-free mass in colorectal cancer patients treated with chemotherapy

Stine Skov Palle; Line Tang Møllehave; Zahra Taheri Kadkhoda; Susanne Johansen; Lisbeth Larsen; Janne Willer Hansen; Nikolaj K G Jensen; Anette O Elingaard; Alice H Møller; Karen Larsen; Jens Rikardt Andersen

doi:10.1016/j.clnesp.2016.09.003

Multi-frequency bioelectrical impedance analysis (BIA) compared to magnetic resonance imaging (MRI) for estimation of fat-free mass in colorectal cancer patients treated with chemotherapy

Stine Skov Palle, Line Tang Møllehave, Zahra Taheri Kadkhoda, Susanne Johansen, Lisbeth Larsen, Janne Willer Hansen, Nikolaj K G Jensen, Anette O Elingaard, Alice H Møller, Karen Larsen, Jens Rikardt Andersen

Nutrition and Health

8 Citations (Scopus)

Abstract

Background: Changes in body composition in cancer patients during chemotherapy are associated with treatment related toxicities or mortalities. Thus, it is relevant to identify accessible, relatively inexpensive, portable and reliable tools for evaluation of body composition in cancer patients during the course of their treatments.

Objective: To examine relationships between single cross-sectional thighs magnetic resonance imaging (MRI), skeletal muscle mass (SM) as reference and multi-frequency bioelectrical impedance analysis (BIA) fat free mass (FFM) in patients with colorectal cancer undergoing chemotherapy.

Design: In an observational, prospective study we examine the relationships between single cross-sectional thighs MRI (T1-weighted (1.5 T) SM compared to FFM BIA (8-electrodes multi-frequency Tanita MC780MA)) and FFM skin-fold thickness (ST) (4-points (Harpenden, Skinfold Caliper)) and SM equation for non-obese persons from Lee et al. 2000 (L2000) (based on age, height, weight, sex and race). FFM and SM (kg) were calculated based on either area (MRI) or weight.

Results: 18 CRC patients (10 males and 8 females) with mean (SD) age 67 yr (6) were measured at baseline, and 13 were available for follow-up. BIA overestimated FFM kg for all 31 measurements with mean (SD) 18.0 kg (6.0) compared to the MRI. ST overestimated FFM kg with mean 12.4 kg (6.2) and L2000 underestimated SM kg in 18 measurements and overestimated in 13 with a total mean of −4.3 kg (6.8). Conclusions BIA and ST were the best alternatives to MRI as they showed constant and thereby correctable errors. The equation, L2000, carried the smallest average measurement error but it was non-constant.

Original language	English
Journal	Clinical Nutrition ESPEN
Volume	16
Pages (from-to)	8-15
Number of pages	8
ISSN	2405-4577
DOIs	https://doi.org/10.1016/j.clnesp.2016.09.003
Publication status	Published - 2016

Keywords

Bioelectrical impedance analysis
Body composition
Colorectal cancer
Fat-free mass
Magnetic resonance imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.clnesp.2016.09.003

Cite this

Palle, S. S., Tang Møllehave, L., Kadkhoda, Z. T., Johansen, S., Larsen, L., Hansen, J. W., Jensen, N. K. G., Elingaard, A. O., Møller, A. H., Larsen, K., & Andersen, J. R. (2016). Multi-frequency bioelectrical impedance analysis (BIA) compared to magnetic resonance imaging (MRI) for estimation of fat-free mass in colorectal cancer patients treated with chemotherapy. Clinical Nutrition ESPEN, 16, 8-15. https://doi.org/10.1016/j.clnesp.2016.09.003

Multi-frequency bioelectrical impedance analysis (BIA) compared to magnetic resonance imaging (MRI) for estimation of fat-free mass in colorectal cancer patients treated with chemotherapy. / Palle, Stine Skov; Tang Møllehave, Line; Kadkhoda, Zahra Taheri et al.

In: Clinical Nutrition ESPEN, Vol. 16, 2016, p. 8-15.

Research output: Contribution to journal › Journal article › Research › peer-review

Palle, SS, Tang Møllehave, L, Kadkhoda, ZT, Johansen, S, Larsen, L, Hansen, JW, Jensen, NKG, Elingaard, AO, Møller, AH, Larsen, K & Andersen, JR 2016, 'Multi-frequency bioelectrical impedance analysis (BIA) compared to magnetic resonance imaging (MRI) for estimation of fat-free mass in colorectal cancer patients treated with chemotherapy', Clinical Nutrition ESPEN, vol. 16, pp. 8-15. https://doi.org/10.1016/j.clnesp.2016.09.003

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title = "Multi-frequency bioelectrical impedance analysis (BIA) compared to magnetic resonance imaging (MRI) for estimation of fat-free mass in colorectal cancer patients treated with chemotherapy",

abstract = "Background: Changes in body composition in cancer patients during chemotherapy are associated with treatment related toxicities or mortalities. Thus, it is relevant to identify accessible, relatively inexpensive, portable and reliable tools for evaluation of body composition in cancer patients during the course of their treatments. Objective: To examine relationships between single cross-sectional thighs magnetic resonance imaging (MRI), skeletal muscle mass (SM) as reference and multi-frequency bioelectrical impedance analysis (BIA) fat free mass (FFM) in patients with colorectal cancer undergoing chemotherapy. Design: In an observational, prospective study we examine the relationships between single cross-sectional thighs MRI (T1-weighted (1.5 T) SM compared to FFM BIA (8-electrodes multi-frequency Tanita MC780MA)) and FFM skin-fold thickness (ST) (4-points (Harpenden, Skinfold Caliper)) and SM equation for non-obese persons from Lee et al. 2000 (L2000) (based on age, height, weight, sex and race). FFM and SM (kg) were calculated based on either area (MRI) or weight.Results: 18 CRC patients (10 males and 8 females) with mean (SD) age 67 yr (6) were measured at baseline, and 13 were available for follow-up. BIA overestimated FFM kg for all 31 measurements with mean (SD) 18.0 kg (6.0) compared to the MRI. ST overestimated FFM kg with mean 12.4 kg (6.2) and L2000 underestimated SM kg in 18 measurements and overestimated in 13 with a total mean of −4.3 kg (6.8). Conclusions BIA and ST were the best alternatives to MRI as they showed constant and thereby correctable errors. The equation, L2000, carried the smallest average measurement error but it was non-constant.",

keywords = "Bioelectrical impedance analysis, Body composition, Colorectal cancer, Fat-free mass, Magnetic resonance imaging",

author = "Palle, {Stine Skov} and {Tang M{\o}llehave}, Line and Kadkhoda, {Zahra Taheri} and Susanne Johansen and Lisbeth Larsen and Hansen, {Janne Willer} and Jensen, {Nikolaj K G} and Elingaard, {Anette O} and M{\o}ller, {Alice H} and Karen Larsen and Andersen, {Jens Rikardt}",

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year = "2016",

doi = "10.1016/j.clnesp.2016.09.003",

language = "English",

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pages = "8--15",

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TY - JOUR

T1 - Multi-frequency bioelectrical impedance analysis (BIA) compared to magnetic resonance imaging (MRI) for estimation of fat-free mass in colorectal cancer patients treated with chemotherapy

AU - Palle, Stine Skov

AU - Tang Møllehave, Line

AU - Kadkhoda, Zahra Taheri

AU - Johansen, Susanne

AU - Larsen, Lisbeth

AU - Hansen, Janne Willer

AU - Jensen, Nikolaj K G

AU - Elingaard, Anette O

AU - Møller, Alice H

AU - Larsen, Karen

AU - Andersen, Jens Rikardt

N1 - CURIS 2016 NEXS 378

PY - 2016

Y1 - 2016

N2 - Background: Changes in body composition in cancer patients during chemotherapy are associated with treatment related toxicities or mortalities. Thus, it is relevant to identify accessible, relatively inexpensive, portable and reliable tools for evaluation of body composition in cancer patients during the course of their treatments. Objective: To examine relationships between single cross-sectional thighs magnetic resonance imaging (MRI), skeletal muscle mass (SM) as reference and multi-frequency bioelectrical impedance analysis (BIA) fat free mass (FFM) in patients with colorectal cancer undergoing chemotherapy. Design: In an observational, prospective study we examine the relationships between single cross-sectional thighs MRI (T1-weighted (1.5 T) SM compared to FFM BIA (8-electrodes multi-frequency Tanita MC780MA)) and FFM skin-fold thickness (ST) (4-points (Harpenden, Skinfold Caliper)) and SM equation for non-obese persons from Lee et al. 2000 (L2000) (based on age, height, weight, sex and race). FFM and SM (kg) were calculated based on either area (MRI) or weight.Results: 18 CRC patients (10 males and 8 females) with mean (SD) age 67 yr (6) were measured at baseline, and 13 were available for follow-up. BIA overestimated FFM kg for all 31 measurements with mean (SD) 18.0 kg (6.0) compared to the MRI. ST overestimated FFM kg with mean 12.4 kg (6.2) and L2000 underestimated SM kg in 18 measurements and overestimated in 13 with a total mean of −4.3 kg (6.8). Conclusions BIA and ST were the best alternatives to MRI as they showed constant and thereby correctable errors. The equation, L2000, carried the smallest average measurement error but it was non-constant.

AB - Background: Changes in body composition in cancer patients during chemotherapy are associated with treatment related toxicities or mortalities. Thus, it is relevant to identify accessible, relatively inexpensive, portable and reliable tools for evaluation of body composition in cancer patients during the course of their treatments. Objective: To examine relationships between single cross-sectional thighs magnetic resonance imaging (MRI), skeletal muscle mass (SM) as reference and multi-frequency bioelectrical impedance analysis (BIA) fat free mass (FFM) in patients with colorectal cancer undergoing chemotherapy. Design: In an observational, prospective study we examine the relationships between single cross-sectional thighs MRI (T1-weighted (1.5 T) SM compared to FFM BIA (8-electrodes multi-frequency Tanita MC780MA)) and FFM skin-fold thickness (ST) (4-points (Harpenden, Skinfold Caliper)) and SM equation for non-obese persons from Lee et al. 2000 (L2000) (based on age, height, weight, sex and race). FFM and SM (kg) were calculated based on either area (MRI) or weight.Results: 18 CRC patients (10 males and 8 females) with mean (SD) age 67 yr (6) were measured at baseline, and 13 were available for follow-up. BIA overestimated FFM kg for all 31 measurements with mean (SD) 18.0 kg (6.0) compared to the MRI. ST overestimated FFM kg with mean 12.4 kg (6.2) and L2000 underestimated SM kg in 18 measurements and overestimated in 13 with a total mean of −4.3 kg (6.8). Conclusions BIA and ST were the best alternatives to MRI as they showed constant and thereby correctable errors. The equation, L2000, carried the smallest average measurement error but it was non-constant.

KW - Bioelectrical impedance analysis

KW - Body composition

KW - Colorectal cancer

KW - Fat-free mass

KW - Magnetic resonance imaging

U2 - 10.1016/j.clnesp.2016.09.003

DO - 10.1016/j.clnesp.2016.09.003

M3 - Journal article

C2 - 28531456

AN - SCOPUS:84993990000

SN - 2405-4577

VL - 16

SP - 8

EP - 15

JO - Clinical Nutrition ESPEN

JF - Clinical Nutrition ESPEN

ER -

Multi-frequency bioelectrical impedance analysis (BIA) compared to magnetic resonance imaging (MRI) for estimation of fat-free mass in colorectal cancer patients treated with chemotherapy

Abstract

Keywords

UN SDGs

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