Mulig terapeutisk intervention med haemmere og fremmere af fosfolipase A 2 -subtyper

Miriam Kolko; Chen Zhan; Jens Rovelt Andreasen; Jan Ulrik Prause; Steffen Heegaard; Miriam Kolko

Mulig terapeutisk intervention med haemmere og fremmere af fosfolipase A 2 -subtyper

Translated title of the contribution: Possible therapeutic intervention with inhibitors and promoters of phospholipase A2 subtypes

Miriam Kolko, Chen Zhan, Jens Rovelt Andreasen, Jan Ulrik Prause, Steffen Heegaard, Miriam Kolko

Abstract

Phospholipase A2 (PLA2) is a group of enzymes discovered more than a century ago in insect and snake poison. Not more than 20 years ago they were identified in vertebrates, and during the last five years, research has accelerated in relation to isolating and cloning several members of this super-family in humans. PLA2 inhibitors are in the process of being developed for pharmaceutical use. The purpose of this review is to outline the relevance and prospectives of PLA2 in a clinical perspective.

Translated title of the contribution	Possible therapeutic intervention with inhibitors and promoters of phospholipase A2 subtypes
Original language	Danish
Journal	Ugeskrift for Laeger
Volume	169
Issue number	2
Pages (from-to)	115-9
Number of pages	5
Publication status	Published - 8 Jan 2007

Cite this

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title = "Mulig terapeutisk intervention med haemmere og fremmere af fosfolipase A 2 -subtyper",

abstract = "Phospholipase A2 (PLA2) is a group of enzymes discovered more than a century ago in insect and snake poison. Not more than 20 years ago they were identified in vertebrates, and during the last five years, research has accelerated in relation to isolating and cloning several members of this super-family in humans. PLA2 inhibitors are in the process of being developed for pharmaceutical use. The purpose of this review is to outline the relevance and prospectives of PLA2 in a clinical perspective.",

keywords = "Brain Diseases, Cardiovascular Diseases, Enzyme Inhibitors, Humans, Inflammation, Neoplasms, Phospholipases A, Phospholipases A2",

author = "Miriam Kolko and Chen Zhan and Andreasen, {Jens Rovelt} and Prause, {Jan Ulrik} and Steffen Heegaard and Miriam Kolko",

year = "2007",

month = jan,

day = "8",

language = "Dansk",

volume = "169",

pages = "115--9",

journal = "Ugeskrift for Laeger",

issn = "0041-5782",

publisher = "Almindelige Danske Laegeforening",

number = "2",

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TY - JOUR

T1 - Mulig terapeutisk intervention med haemmere og fremmere af fosfolipase A 2 -subtyper

AU - Kolko, Miriam

AU - Zhan, Chen

AU - Andreasen, Jens Rovelt

AU - Prause, Jan Ulrik

AU - Heegaard, Steffen

AU - Kolko, Miriam

PY - 2007/1/8

Y1 - 2007/1/8

N2 - Phospholipase A2 (PLA2) is a group of enzymes discovered more than a century ago in insect and snake poison. Not more than 20 years ago they were identified in vertebrates, and during the last five years, research has accelerated in relation to isolating and cloning several members of this super-family in humans. PLA2 inhibitors are in the process of being developed for pharmaceutical use. The purpose of this review is to outline the relevance and prospectives of PLA2 in a clinical perspective.

AB - Phospholipase A2 (PLA2) is a group of enzymes discovered more than a century ago in insect and snake poison. Not more than 20 years ago they were identified in vertebrates, and during the last five years, research has accelerated in relation to isolating and cloning several members of this super-family in humans. PLA2 inhibitors are in the process of being developed for pharmaceutical use. The purpose of this review is to outline the relevance and prospectives of PLA2 in a clinical perspective.

KW - Brain Diseases

KW - Cardiovascular Diseases

KW - Enzyme Inhibitors

KW - Humans

KW - Inflammation

KW - Neoplasms

KW - Phospholipases A

KW - Phospholipases A2

M3 - Tidsskriftartikel

C2 - 17227656

SN - 0041-5782

VL - 169

SP - 115

EP - 119

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 2

ER -

Mulig terapeutisk intervention med haemmere og fremmere af fosfolipase A 2 -subtyper

Abstract

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