Mucosal symptoms elicited by fragrance products in a population-based sample in relation to atopy and bronchial hyper-reactivity

J Elberling; A Linneberg; A Dirksen; J D Johansen; L Frølund; F Madsen; N H Nielsen; H Mosbech

doi:10.1111/j.1365-2222.2005.02138.x

Mucosal symptoms elicited by fragrance products in a population-based sample in relation to atopy and bronchial hyper-reactivity

J Elberling, A Linneberg, A Dirksen, J D Johansen, L Frølund, F Madsen, N H Nielsen, H Mosbech

66 Citations (Scopus)

Abstract

BACKGROUND: Exposure to perfume and fragrance products may, in some individuals, cause symptoms from the eyes and airways. The localization, character and risk factors of such symptoms in the general population are unknown.

OBJECTIVE: To investigate both the localization and character of symptoms from the eyes and airways elicited by fragrance products, and the associations between such symptoms and skin prick test reactivity (atopy), methacholine bronchial hyper-reactivity (BHR), allergic rhinitis and asthma.

METHODS: A questionnaire on mucosal symptoms elicited by fragrance products was posted to 1189 persons who had participated in a Danish population-based study of allergic diseases in 1997/1998. The study included measurement of BHR, atopy, forced expiratory volume in 1 s (FEV1), and serum eosinophilic cationic protein (serum ECP).

RESULTS: The response rate was 79.6%. Symptoms from the eyes or airways elicited by fragrance products were reported by 42%. BHR (adjusted odds ratio 2.3, 95% confidence interval 1.5-3.5) was independently associated with symptoms from the eyes and airways elicited by fragrance products. There were no significant associations between these symptoms and atopy, FEV1 or serum ECP.

CONCLUSIONS: Mucosal symptoms from the eyes and airways were common in this population. BHR was a significant and independent predictor of these symptoms. The lack of association with atopy suggested that IgE-mediated allergic mechanisms do not play a major role in the development of these symptoms.

Original language	English
Journal	Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Volume	35
Issue number	1
Pages (from-to)	75-81
Number of pages	7
ISSN	0954-7894
DOIs	https://doi.org/10.1111/j.1365-2222.2005.02138.x
Publication status	Published - Jan 2005

Keywords

Asthma
Bronchi
Bronchial Hyperreactivity
Bronchoconstrictor Agents
Case-Control Studies
Chi-Square Distribution
Eosinophil Cationic Protein
Eye
Eye Diseases
Forced Expiratory Volume
Humans
Methacholine Chloride
Mucous Membrane
Multiple Chemical Sensitivity
Perfume
Skin Tests
Journal Article

Access to Document

10.1111/j.1365-2222.2005.02138.x

Cite this

Elberling, J., Linneberg, A., Dirksen, A., Johansen, J. D., Frølund, L., Madsen, F., Nielsen, N. H., & Mosbech, H. (2005). Mucosal symptoms elicited by fragrance products in a population-based sample in relation to atopy and bronchial hyper-reactivity. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 35(1), 75-81. https://doi.org/10.1111/j.1365-2222.2005.02138.x

Mucosal symptoms elicited by fragrance products in a population-based sample in relation to atopy and bronchial hyper-reactivity. / Elberling, J ; Linneberg, A; Dirksen, A et al.

In: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, Vol. 35, No. 1, 01.2005, p. 75-81.

Research output: Contribution to journal › Journal article › Research › peer-review

Elberling, J , Linneberg, A, Dirksen, A, Johansen, JD, Frølund, L, Madsen, F, Nielsen, NH & Mosbech, H 2005, 'Mucosal symptoms elicited by fragrance products in a population-based sample in relation to atopy and bronchial hyper-reactivity', Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, vol. 35, no. 1, pp. 75-81. https://doi.org/10.1111/j.1365-2222.2005.02138.x

Elberling J , Linneberg A, Dirksen A, Johansen JD, Frølund L, Madsen F et al. Mucosal symptoms elicited by fragrance products in a population-based sample in relation to atopy and bronchial hyper-reactivity. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2005 Jan;35(1):75-81. doi: 10.1111/j.1365-2222.2005.02138.x

@article{ae4a1d535ca34e29abf656b536797022,

title = "Mucosal symptoms elicited by fragrance products in a population-based sample in relation to atopy and bronchial hyper-reactivity",

abstract = "BACKGROUND: Exposure to perfume and fragrance products may, in some individuals, cause symptoms from the eyes and airways. The localization, character and risk factors of such symptoms in the general population are unknown.OBJECTIVE: To investigate both the localization and character of symptoms from the eyes and airways elicited by fragrance products, and the associations between such symptoms and skin prick test reactivity (atopy), methacholine bronchial hyper-reactivity (BHR), allergic rhinitis and asthma.METHODS: A questionnaire on mucosal symptoms elicited by fragrance products was posted to 1189 persons who had participated in a Danish population-based study of allergic diseases in 1997/1998. The study included measurement of BHR, atopy, forced expiratory volume in 1 s (FEV1), and serum eosinophilic cationic protein (serum ECP).RESULTS: The response rate was 79.6%. Symptoms from the eyes or airways elicited by fragrance products were reported by 42%. BHR (adjusted odds ratio 2.3, 95% confidence interval 1.5-3.5) was independently associated with symptoms from the eyes and airways elicited by fragrance products. There were no significant associations between these symptoms and atopy, FEV1 or serum ECP.CONCLUSIONS: Mucosal symptoms from the eyes and airways were common in this population. BHR was a significant and independent predictor of these symptoms. The lack of association with atopy suggested that IgE-mediated allergic mechanisms do not play a major role in the development of these symptoms.",

keywords = "Asthma, Bronchi, Bronchial Hyperreactivity, Bronchoconstrictor Agents, Case-Control Studies, Chi-Square Distribution, Eosinophil Cationic Protein, Eye, Eye Diseases, Forced Expiratory Volume, Humans, Methacholine Chloride, Mucous Membrane, Multiple Chemical Sensitivity, Perfume, Skin Tests, Journal Article",

author = "J Elberling and A Linneberg and A Dirksen and Johansen, {J D} and L Fr{\o}lund and F Madsen and Nielsen, {N H} and H Mosbech",

year = "2005",

month = jan,

doi = "10.1111/j.1365-2222.2005.02138.x",

language = "English",

volume = "35",

pages = "75--81",

journal = "Clinical Allergy",

issn = "0954-7894",

publisher = "Wiley-Blackwell",

number = "1",

}

TY - JOUR

T1 - Mucosal symptoms elicited by fragrance products in a population-based sample in relation to atopy and bronchial hyper-reactivity

AU - Elberling, J

AU - Linneberg, A

AU - Dirksen, A

AU - Johansen, J D

AU - Frølund, L

AU - Madsen, F

AU - Nielsen, N H

AU - Mosbech, H

PY - 2005/1

Y1 - 2005/1

N2 - BACKGROUND: Exposure to perfume and fragrance products may, in some individuals, cause symptoms from the eyes and airways. The localization, character and risk factors of such symptoms in the general population are unknown.OBJECTIVE: To investigate both the localization and character of symptoms from the eyes and airways elicited by fragrance products, and the associations between such symptoms and skin prick test reactivity (atopy), methacholine bronchial hyper-reactivity (BHR), allergic rhinitis and asthma.METHODS: A questionnaire on mucosal symptoms elicited by fragrance products was posted to 1189 persons who had participated in a Danish population-based study of allergic diseases in 1997/1998. The study included measurement of BHR, atopy, forced expiratory volume in 1 s (FEV1), and serum eosinophilic cationic protein (serum ECP).RESULTS: The response rate was 79.6%. Symptoms from the eyes or airways elicited by fragrance products were reported by 42%. BHR (adjusted odds ratio 2.3, 95% confidence interval 1.5-3.5) was independently associated with symptoms from the eyes and airways elicited by fragrance products. There were no significant associations between these symptoms and atopy, FEV1 or serum ECP.CONCLUSIONS: Mucosal symptoms from the eyes and airways were common in this population. BHR was a significant and independent predictor of these symptoms. The lack of association with atopy suggested that IgE-mediated allergic mechanisms do not play a major role in the development of these symptoms.

AB - BACKGROUND: Exposure to perfume and fragrance products may, in some individuals, cause symptoms from the eyes and airways. The localization, character and risk factors of such symptoms in the general population are unknown.OBJECTIVE: To investigate both the localization and character of symptoms from the eyes and airways elicited by fragrance products, and the associations between such symptoms and skin prick test reactivity (atopy), methacholine bronchial hyper-reactivity (BHR), allergic rhinitis and asthma.METHODS: A questionnaire on mucosal symptoms elicited by fragrance products was posted to 1189 persons who had participated in a Danish population-based study of allergic diseases in 1997/1998. The study included measurement of BHR, atopy, forced expiratory volume in 1 s (FEV1), and serum eosinophilic cationic protein (serum ECP).RESULTS: The response rate was 79.6%. Symptoms from the eyes or airways elicited by fragrance products were reported by 42%. BHR (adjusted odds ratio 2.3, 95% confidence interval 1.5-3.5) was independently associated with symptoms from the eyes and airways elicited by fragrance products. There were no significant associations between these symptoms and atopy, FEV1 or serum ECP.CONCLUSIONS: Mucosal symptoms from the eyes and airways were common in this population. BHR was a significant and independent predictor of these symptoms. The lack of association with atopy suggested that IgE-mediated allergic mechanisms do not play a major role in the development of these symptoms.

KW - Asthma

KW - Bronchi

KW - Bronchial Hyperreactivity

KW - Bronchoconstrictor Agents

KW - Case-Control Studies

KW - Chi-Square Distribution

KW - Eosinophil Cationic Protein

KW - Eye

KW - Eye Diseases

KW - Forced Expiratory Volume

KW - Humans

KW - Methacholine Chloride

KW - Mucous Membrane

KW - Multiple Chemical Sensitivity

KW - Perfume

KW - Skin Tests

KW - Journal Article

U2 - 10.1111/j.1365-2222.2005.02138.x

DO - 10.1111/j.1365-2222.2005.02138.x

M3 - Journal article

C2 - 15649270

SN - 0954-7894

VL - 35

SP - 75

EP - 81

JO - Clinical Allergy

JF - Clinical Allergy

IS - 1

ER -

Mucosal symptoms elicited by fragrance products in a population-based sample in relation to atopy and bronchial hyper-reactivity

Abstract

Keywords

Access to Document

Fingerprint

Cite this