Mucosal surface morphology and histological changes in the duodenum of the rat following administration of cysteamine

TY - JOUR

T1 - Mucosal surface morphology and histological changes in the duodenum of the rat following administration of cysteamine

AU - Poulsen, Steen Seier

AU - Szabo, S

PY - 1977/2

Y1 - 1977/2

N2 - Acute duodenal ulcer can be produced in the rat by subcutaneous or oral administration of cysteamine. Development of this ulcer on the intestinal mucosal surface was followed from precursory stages to perforation using low power semimacroscopical and conventional histological techniques. The process started in the epithelium of the apical parts of the villi where segments of surface epithelial cells exfoliated and the lamina propria seemed to retract. As the process continued the villi gradually became lower eventually forming an avillous surface. Subsequently defects in the epithelium, necrosis, inflammation of the lamina propria, and a localized ulcer developed.

AB - Acute duodenal ulcer can be produced in the rat by subcutaneous or oral administration of cysteamine. Development of this ulcer on the intestinal mucosal surface was followed from precursory stages to perforation using low power semimacroscopical and conventional histological techniques. The process started in the epithelium of the apical parts of the villi where segments of surface epithelial cells exfoliated and the lamina propria seemed to retract. As the process continued the villi gradually became lower eventually forming an avillous surface. Subsequently defects in the epithelium, necrosis, inflammation of the lamina propria, and a localized ulcer developed.

KW - Animals

KW - Cysteamine

KW - Duodenal Ulcer

KW - Duodenum

KW - Female

KW - Intestinal Mucosa

KW - Rats

M3 - Journal article

C2 - 836762

SN - 0007-1021

VL - 58

SP - 1

EP - 8

JO - British Journal of Experimental Pathology

JF - British Journal of Experimental Pathology

IS - 1

ER -