MRI quantification of rheumatoid arthritis: current knowledge and future perspectives

Mikael Boesen; Mikkel Østergaard; Marco A Cimmino; Olga Kubassova; Karl Erik Jensen; Henning Bliddal; Mikael Boesen; Mikkel Østergaard; Marco A Cimmino; Olga Kubassova; Karl Erik Jensen; Henning Bliddal

doi:10.1016/j.ejrad.2009.04.048

MRI quantification of rheumatoid arthritis: current knowledge and future perspectives

Mikael Boesen, Mikkel Østergaard, Marco A Cimmino, Olga Kubassova, Karl Erik Jensen, Henning Bliddal, Mikael Boesen, Mikkel Østergaard, Marco A Cimmino, Olga Kubassova, Karl Erik Jensen, Henning Bliddal

50 Citations (Scopus)

Abstract

The international consensus on treatment of rheumatoid arthritis (RA) involves early initiation of disease modifying anti-rheumatic drugs (DMARDs) for which a reliable identification of early disease is mandatory. Conventional radiography of the joints is considered the standard method for detecting and quantifying joint damage in RA. However, radiographs only show late disease manifestations as joint space narrowing and bone erosions, whereas it cannot detect synovitis and bone marrow oedema, i.e., inflammation in the synovium or the bone, which may be visualized by magnetic resonance imaging (MRI) months to years before erosions develop. Furthermore, MRI allows earlier visualization of bone erosions than radiography. In order to allow early treatment initiation and optimal guidance of the therapeutic strategy, there is a need for methods which are capable of early detection of inflammatory joint changes. In this review, we will discuss available data, advantages, limitations and potential future of MRI in RA.

Original language	English
Journal	European Journal of Radiology
Volume	71
Issue number	2
Pages (from-to)	189-96
Number of pages	7
ISSN	0720-048X
DOIs	https://doi.org/10.1016/j.ejrad.2009.04.048 https://doi.org/10.1016/j.ejrad.2009.04.048
Publication status	Published - 2009

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Boesen, M., Østergaard, M., Cimmino, M. A., Kubassova, O., Jensen, K. E., Bliddal, H., Boesen, M., Østergaard, M., Cimmino, M. A., Kubassova, O., Jensen, K. E., & Bliddal, H. (2009). MRI quantification of rheumatoid arthritis: current knowledge and future perspectives. European Journal of Radiology, 71(2), 189-96. https://doi.org/10.1016/j.ejrad.2009.04.048, https://doi.org/10.1016/j.ejrad.2009.04.048

Boesen, M , Østergaard, M, Cimmino, MA, Kubassova, O, Jensen, KE, Bliddal, H, Boesen, M, Østergaard, M, Cimmino, MA, Kubassova, O, Jensen, KE & Bliddal, H 2009, 'MRI quantification of rheumatoid arthritis: current knowledge and future perspectives', European Journal of Radiology, vol. 71, no. 2, pp. 189-96. https://doi.org/10.1016/j.ejrad.2009.04.048, https://doi.org/10.1016/j.ejrad.2009.04.048

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title = "MRI quantification of rheumatoid arthritis: current knowledge and future perspectives",

abstract = "The international consensus on treatment of rheumatoid arthritis (RA) involves early initiation of disease modifying anti-rheumatic drugs (DMARDs) for which a reliable identification of early disease is mandatory. Conventional radiography of the joints is considered the standard method for detecting and quantifying joint damage in RA. However, radiographs only show late disease manifestations as joint space narrowing and bone erosions, whereas it cannot detect synovitis and bone marrow oedema, i.e., inflammation in the synovium or the bone, which may be visualized by magnetic resonance imaging (MRI) months to years before erosions develop. Furthermore, MRI allows earlier visualization of bone erosions than radiography. In order to allow early treatment initiation and optimal guidance of the therapeutic strategy, there is a need for methods which are capable of early detection of inflammatory joint changes. In this review, we will discuss available data, advantages, limitations and potential future of MRI in RA.",

author = "Mikael Boesen and Mikkel {\O}stergaard and Cimmino, {Marco A} and Olga Kubassova and Jensen, {Karl Erik} and Henning Bliddal and Mikael Boesen and Mikkel {\O}stergaard and Cimmino, {Marco A} and Olga Kubassova and Jensen, {Karl Erik} and Henning Bliddal",

note = "Keywords: Arthritis, Rheumatoid; Forecasting; Health Knowledge, Attitudes, Practice; Image Enhancement; Magnetic Resonance Imaging",

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doi = "10.1016/j.ejrad.2009.04.048",

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T1 - MRI quantification of rheumatoid arthritis: current knowledge and future perspectives

AU - Boesen, Mikael

AU - Østergaard, Mikkel

AU - Cimmino, Marco A

AU - Kubassova, Olga

AU - Jensen, Karl Erik

AU - Bliddal, Henning

AU - Boesen, Mikael

AU - Østergaard, Mikkel

AU - Cimmino, Marco A

AU - Kubassova, Olga

AU - Jensen, Karl Erik

AU - Bliddal, Henning

N1 - Keywords: Arthritis, Rheumatoid; Forecasting; Health Knowledge, Attitudes, Practice; Image Enhancement; Magnetic Resonance Imaging

PY - 2009

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N2 - The international consensus on treatment of rheumatoid arthritis (RA) involves early initiation of disease modifying anti-rheumatic drugs (DMARDs) for which a reliable identification of early disease is mandatory. Conventional radiography of the joints is considered the standard method for detecting and quantifying joint damage in RA. However, radiographs only show late disease manifestations as joint space narrowing and bone erosions, whereas it cannot detect synovitis and bone marrow oedema, i.e., inflammation in the synovium or the bone, which may be visualized by magnetic resonance imaging (MRI) months to years before erosions develop. Furthermore, MRI allows earlier visualization of bone erosions than radiography. In order to allow early treatment initiation and optimal guidance of the therapeutic strategy, there is a need for methods which are capable of early detection of inflammatory joint changes. In this review, we will discuss available data, advantages, limitations and potential future of MRI in RA.

AB - The international consensus on treatment of rheumatoid arthritis (RA) involves early initiation of disease modifying anti-rheumatic drugs (DMARDs) for which a reliable identification of early disease is mandatory. Conventional radiography of the joints is considered the standard method for detecting and quantifying joint damage in RA. However, radiographs only show late disease manifestations as joint space narrowing and bone erosions, whereas it cannot detect synovitis and bone marrow oedema, i.e., inflammation in the synovium or the bone, which may be visualized by magnetic resonance imaging (MRI) months to years before erosions develop. Furthermore, MRI allows earlier visualization of bone erosions than radiography. In order to allow early treatment initiation and optimal guidance of the therapeutic strategy, there is a need for methods which are capable of early detection of inflammatory joint changes. In this review, we will discuss available data, advantages, limitations and potential future of MRI in RA.

U2 - 10.1016/j.ejrad.2009.04.048

DO - 10.1016/j.ejrad.2009.04.048

M3 - Journal article

C2 - 19477615

SN - 0720-048X

VL - 71

SP - 189

EP - 196

JO - European Journal of Radiology

JF - European Journal of Radiology

IS - 2

ER -

MRI quantification of rheumatoid arthritis: current knowledge and future perspectives

Abstract

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