Mortality Rates in Patients With Chronic Hepatitis C and Cirrhosis Compared With the General Population: A Danish Cohort Study

Sofie Hallager; Peer Brehm Christensen; Steen Ladelund; Mette Rye Clausen; Alex Lund Laursen; Axel Møller; Poul Schlicthting; Lone Galmstrup Madsen; Jan Gerstoft; Suzanne Lunding; Karin Elmegård Grønbæk; Henrik Bygum Krarup; Nina Weis

doi:10.1093/infdis/jiw527

Mortality Rates in Patients With Chronic Hepatitis C and Cirrhosis Compared With the General Population: A Danish Cohort Study

Sofie Hallager, Peer Brehm Christensen, Steen Ladelund, Mette Rye Clausen, Alex Lund Laursen, Axel Møller, Poul Schlicthting, Lone Galmstrup Madsen, Jan Gerstoft, Suzanne Lunding, Karin Elmegård Grønbæk, Henrik Bygum Krarup, Nina Weis

Department of Clinical Medicine

9 Citations (Scopus)

Abstract

Background: Knowledge about mortality rates (MRs) in patients with chronic hepatitis C (CHC) with cirrhosis is limited. This study aimed to estimate all-cause MRs among patients with CHC with or without cirrhosis in Denmark compared with the general population.

Methods: Patients registered in the Danish Database for Hepatitis B and C with CHC and a liver fibrosis assessment were eligible for inclusion. Liver fibrosis was assessed by means of liver biopsy, transient elastography, and clinical cirrhosis. Up to 20 sex- and age-matched individuals per patient were identified in the general population. Data were extracted from nationwide registries.

Results: A total of 3410 patients with CHC (1014 with cirrhosis), and 67 315 matched individuals were included. Adjusted MR ratios (MRRs) between patients with or without cirrhosis and their comparison cohorts were 5.64 (95% confidence interval [CI], 4.76-6.67) and 1.94 (1.55-2.42), respectively. Cirrhosis among patients was associated with an MRR of 4.03 (95% CI, 3.43-4.72). A cure for CHC was associated with an MRR of 0.64 (95% CI, 0.40-1.01) among cirrhotic patients and 2.33 (1.47-3.67) compared with the general population.

Conclusions: MRs were high among patients with CHC with or without cirrhosis compared with the general population. Curing CHC was associated with a reduction in MR among cirrhotic patients, but the MR remained higher than the general population.

Original language	English
Journal	The Journal of Infectious Diseases
Volume	215
Issue number	2
Pages (from-to)	192-201
Number of pages	10
ISSN	0022-1899
DOIs	https://doi.org/10.1093/infdis/jiw527
Publication status	Published - 15 Jan 2017

Keywords

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Hallager, S., Brehm Christensen, P., Ladelund, S., Clausen, M. R., Lund Laursen, A., Møller, A., Schlicthting, P., Galmstrup Madsen, L., Gerstoft, J., Lunding, S., Grønbæk, K. E., Bygum Krarup, H., & Weis, N. (2017). Mortality Rates in Patients With Chronic Hepatitis C and Cirrhosis Compared With the General Population: A Danish Cohort Study. The Journal of Infectious Diseases, 215(2), 192-201. https://doi.org/10.1093/infdis/jiw527

Hallager, S, Brehm Christensen, P, Ladelund, S, Clausen, MR, Lund Laursen, A, Møller, A, Schlicthting, P, Galmstrup Madsen, L , Gerstoft, J, Lunding, S, Grønbæk, KE, Bygum Krarup, H & Weis, N 2017, 'Mortality Rates in Patients With Chronic Hepatitis C and Cirrhosis Compared With the General Population: A Danish Cohort Study', The Journal of Infectious Diseases, vol. 215, no. 2, pp. 192-201. https://doi.org/10.1093/infdis/jiw527

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title = "Mortality Rates in Patients With Chronic Hepatitis C and Cirrhosis Compared With the General Population: A Danish Cohort Study",

abstract = "Background: Knowledge about mortality rates (MRs) in patients with chronic hepatitis C (CHC) with cirrhosis is limited. This study aimed to estimate all-cause MRs among patients with CHC with or without cirrhosis in Denmark compared with the general population.Methods: Patients registered in the Danish Database for Hepatitis B and C with CHC and a liver fibrosis assessment were eligible for inclusion. Liver fibrosis was assessed by means of liver biopsy, transient elastography, and clinical cirrhosis. Up to 20 sex- and age-matched individuals per patient were identified in the general population. Data were extracted from nationwide registries.Results: A total of 3410 patients with CHC (1014 with cirrhosis), and 67 315 matched individuals were included. Adjusted MR ratios (MRRs) between patients with or without cirrhosis and their comparison cohorts were 5.64 (95% confidence interval [CI], 4.76-6.67) and 1.94 (1.55-2.42), respectively. Cirrhosis among patients was associated with an MRR of 4.03 (95% CI, 3.43-4.72). A cure for CHC was associated with an MRR of 0.64 (95% CI, 0.40-1.01) among cirrhotic patients and 2.33 (1.47-3.67) compared with the general population.Conclusions: MRs were high among patients with CHC with or without cirrhosis compared with the general population. Curing CHC was associated with a reduction in MR among cirrhotic patients, but the MR remained higher than the general population.",

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author = "Sofie Hallager and {Brehm Christensen}, Peer and Steen Ladelund and Clausen, {Mette Rye} and {Lund Laursen}, Alex and Axel M{\o}ller and Poul Schlicthting and {Galmstrup Madsen}, Lone and Jan Gerstoft and Suzanne Lunding and Gr{\o}nb{\ae}k, {Karin Elmeg{\aa}rd} and {Bygum Krarup}, Henrik and Nina Weis",

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doi = "10.1093/infdis/jiw527",

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T1 - Mortality Rates in Patients With Chronic Hepatitis C and Cirrhosis Compared With the General Population

T2 - A Danish Cohort Study

AU - Hallager, Sofie

AU - Brehm Christensen, Peer

AU - Ladelund, Steen

AU - Clausen, Mette Rye

AU - Lund Laursen, Alex

AU - Møller, Axel

AU - Schlicthting, Poul

AU - Galmstrup Madsen, Lone

AU - Gerstoft, Jan

AU - Lunding, Suzanne

AU - Grønbæk, Karin Elmegård

AU - Bygum Krarup, Henrik

AU - Weis, Nina

PY - 2017/1/15

Y1 - 2017/1/15

N2 - Background: Knowledge about mortality rates (MRs) in patients with chronic hepatitis C (CHC) with cirrhosis is limited. This study aimed to estimate all-cause MRs among patients with CHC with or without cirrhosis in Denmark compared with the general population.Methods: Patients registered in the Danish Database for Hepatitis B and C with CHC and a liver fibrosis assessment were eligible for inclusion. Liver fibrosis was assessed by means of liver biopsy, transient elastography, and clinical cirrhosis. Up to 20 sex- and age-matched individuals per patient were identified in the general population. Data were extracted from nationwide registries.Results: A total of 3410 patients with CHC (1014 with cirrhosis), and 67 315 matched individuals were included. Adjusted MR ratios (MRRs) between patients with or without cirrhosis and their comparison cohorts were 5.64 (95% confidence interval [CI], 4.76-6.67) and 1.94 (1.55-2.42), respectively. Cirrhosis among patients was associated with an MRR of 4.03 (95% CI, 3.43-4.72). A cure for CHC was associated with an MRR of 0.64 (95% CI, 0.40-1.01) among cirrhotic patients and 2.33 (1.47-3.67) compared with the general population.Conclusions: MRs were high among patients with CHC with or without cirrhosis compared with the general population. Curing CHC was associated with a reduction in MR among cirrhotic patients, but the MR remained higher than the general population.

AB - Background: Knowledge about mortality rates (MRs) in patients with chronic hepatitis C (CHC) with cirrhosis is limited. This study aimed to estimate all-cause MRs among patients with CHC with or without cirrhosis in Denmark compared with the general population.Methods: Patients registered in the Danish Database for Hepatitis B and C with CHC and a liver fibrosis assessment were eligible for inclusion. Liver fibrosis was assessed by means of liver biopsy, transient elastography, and clinical cirrhosis. Up to 20 sex- and age-matched individuals per patient were identified in the general population. Data were extracted from nationwide registries.Results: A total of 3410 patients with CHC (1014 with cirrhosis), and 67 315 matched individuals were included. Adjusted MR ratios (MRRs) between patients with or without cirrhosis and their comparison cohorts were 5.64 (95% confidence interval [CI], 4.76-6.67) and 1.94 (1.55-2.42), respectively. Cirrhosis among patients was associated with an MRR of 4.03 (95% CI, 3.43-4.72). A cure for CHC was associated with an MRR of 0.64 (95% CI, 0.40-1.01) among cirrhotic patients and 2.33 (1.47-3.67) compared with the general population.Conclusions: MRs were high among patients with CHC with or without cirrhosis compared with the general population. Curing CHC was associated with a reduction in MR among cirrhotic patients, but the MR remained higher than the general population.

KW - Journal Article

U2 - 10.1093/infdis/jiw527

DO - 10.1093/infdis/jiw527

M3 - Journal article

C2 - 27803168

SN - 0022-1899

VL - 215

SP - 192

EP - 201

JO - The Journal of Infectious Diseases

JF - The Journal of Infectious Diseases

IS - 2

ER -

Mortality Rates in Patients With Chronic Hepatitis C and Cirrhosis Compared With the General Population: A Danish Cohort Study

Abstract

Keywords

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