Mortality, Cancer, and Comorbidities Associated With Chronic Pancreatitis: A Danish Nationwide Matched-Cohort Study

Ulrich Christian Bang; Thomas Benfield; Lars Hyldstrup; Flemming Bendtsen; Jens-Erik Beck Jensen

doi:10.1053/j.gastro.2013.12.033

Mortality, Cancer, and Comorbidities Associated With Chronic Pancreatitis: A Danish Nationwide Matched-Cohort Study

Ulrich Christian Bang, Thomas Benfield, Lars Hyldstrup, Flemming Bendtsen, Jens-Erik Beck Jensen

110 Citations (Scopus)

Abstract

Background & Aims We aimed to assess the risk of death, cancer, and comorbidities among patients with alcoholic and nonalcoholic chronic pancreatitis (CP). Methods We performed a nationwide retrospective cohort study, collecting data from Danish registries from 1995 through 2010. We evaluated the prevalences and incidences of death, cancers, and comorbidities among subjects with CP (cases) compared with age- and sex-matched individuals (controls). In total, 11,972 cases (71,814 person-years) and 119,720 controls (917,436 person-years) were included in the analysis. Hazard ratios (HR) were estimated by Cox proportional hazards regression. Results Forty-six percent of the cases died during the follow-up period, compared with 13.0% of controls (mean age, 63.7 vs 72.1 y; P <.0001), corresponding to a HR of 5.0 for CP (95% confidence interval [CI], 4.8-5.2). Cancer was a frequent cause of death among cases (10.2%) and controls (3.3%). Cancer (particularly pancreatic cancer) was a frequent cause of death among cases; the HR was 6.9 (95% CI, 7.5-11.8). Alcoholic CP did not produce a higher risk for cancer or death than nonalcoholic CP. Cerebrovascular disease (HR, 1.3; 95% CI, 1.2-1.4), chronic pulmonary disease (HR, 1.9; 95% CI, 1.8-2.1), ulcer disease (HR, 3.6; 95% CI, 3.3-3.9), diabetes (HR, 5.2; 95% CI, 5.0-5.6), and chronic renal disease (HR, 1.7; 95% CI, 1.5-1.9) occurred more frequently among patients with CP, but myocardial infarction did not (HR, 0.9; 95% CI, 0.8-1.0). Conclusions Based on a Danish nationwide cohort study, individuals with CP are at higher risk for death from cancer (particularly pancreatic cancer) and have a higher incidence of comorbidities than people without CP.

Original language	English
Journal	Gastroenterology
Volume	146
Issue number	4
Pages (from-to)	989-994
Number of pages	6
ISSN	0016-5085
DOIs	https://doi.org/10.1053/j.gastro.2013.12.033
Publication status	Published - Apr 2014

Keywords

Adult
Aged
Chi-Square Distribution
Comorbidity
Denmark
Female
Humans
Incidence
Male
Middle Aged
Multivariate Analysis
Neoplasms
Pancreatic Neoplasms
Pancreatitis, Alcoholic
Pancreatitis, Chronic
Prevalence
Prognosis
Proportional Hazards Models
Registries
Retrospective Studies
Risk Factors
Time Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1053/j.gastro.2013.12.033

http://www.gastrojournal.org/article/S0016508513018477/pdf

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@article{cb17790fe1d54a60a23854c4806a4554,

title = "Mortality, Cancer, and Comorbidities Associated With Chronic Pancreatitis: A Danish Nationwide Matched-Cohort Study ",

abstract = "Background & Aims We aimed to assess the risk of death, cancer, and comorbidities among patients with alcoholic and nonalcoholic chronic pancreatitis (CP). Methods We performed a nationwide retrospective cohort study, collecting data from Danish registries from 1995 through 2010. We evaluated the prevalences and incidences of death, cancers, and comorbidities among subjects with CP (cases) compared with age- and sex-matched individuals (controls). In total, 11,972 cases (71,814 person-years) and 119,720 controls (917,436 person-years) were included in the analysis. Hazard ratios (HR) were estimated by Cox proportional hazards regression. Results Forty-six percent of the cases died during the follow-up period, compared with 13.0% of controls (mean age, 63.7 vs 72.1 y; P <.0001), corresponding to a HR of 5.0 for CP (95% confidence interval [CI], 4.8-5.2). Cancer was a frequent cause of death among cases (10.2%) and controls (3.3%). Cancer (particularly pancreatic cancer) was a frequent cause of death among cases; the HR was 6.9 (95% CI, 7.5-11.8). Alcoholic CP did not produce a higher risk for cancer or death than nonalcoholic CP. Cerebrovascular disease (HR, 1.3; 95% CI, 1.2-1.4), chronic pulmonary disease (HR, 1.9; 95% CI, 1.8-2.1), ulcer disease (HR, 3.6; 95% CI, 3.3-3.9), diabetes (HR, 5.2; 95% CI, 5.0-5.6), and chronic renal disease (HR, 1.7; 95% CI, 1.5-1.9) occurred more frequently among patients with CP, but myocardial infarction did not (HR, 0.9; 95% CI, 0.8-1.0). Conclusions Based on a Danish nationwide cohort study, individuals with CP are at higher risk for death from cancer (particularly pancreatic cancer) and have a higher incidence of comorbidities than people without CP.",

keywords = "Adult, Aged, Chi-Square Distribution, Comorbidity, Denmark, Female, Humans, Incidence, Male, Middle Aged, Multivariate Analysis, Neoplasms, Pancreatic Neoplasms, Pancreatitis, Alcoholic, Pancreatitis, Chronic, Prevalence, Prognosis, Proportional Hazards Models, Registries, Retrospective Studies, Risk Factors, Time Factors",

author = "Bang, {Ulrich Christian} and Thomas Benfield and Lars Hyldstrup and Flemming Bendtsen and {Beck Jensen}, Jens-Erik",

year = "2014",

month = apr,

doi = "10.1053/j.gastro.2013.12.033",

language = "English",

volume = "146",

pages = "989--994",

journal = "Gastroenterology",

issn = "0016-5085",

publisher = "Elsevier",

number = "4",

}

TY - JOUR

T1 - Mortality, Cancer, and Comorbidities Associated With Chronic Pancreatitis

T2 - A Danish Nationwide Matched-Cohort Study

AU - Bang, Ulrich Christian

AU - Benfield, Thomas

AU - Hyldstrup, Lars

AU - Bendtsen, Flemming

AU - Beck Jensen, Jens-Erik

PY - 2014/4

Y1 - 2014/4

N2 - Background & Aims We aimed to assess the risk of death, cancer, and comorbidities among patients with alcoholic and nonalcoholic chronic pancreatitis (CP). Methods We performed a nationwide retrospective cohort study, collecting data from Danish registries from 1995 through 2010. We evaluated the prevalences and incidences of death, cancers, and comorbidities among subjects with CP (cases) compared with age- and sex-matched individuals (controls). In total, 11,972 cases (71,814 person-years) and 119,720 controls (917,436 person-years) were included in the analysis. Hazard ratios (HR) were estimated by Cox proportional hazards regression. Results Forty-six percent of the cases died during the follow-up period, compared with 13.0% of controls (mean age, 63.7 vs 72.1 y; P <.0001), corresponding to a HR of 5.0 for CP (95% confidence interval [CI], 4.8-5.2). Cancer was a frequent cause of death among cases (10.2%) and controls (3.3%). Cancer (particularly pancreatic cancer) was a frequent cause of death among cases; the HR was 6.9 (95% CI, 7.5-11.8). Alcoholic CP did not produce a higher risk for cancer or death than nonalcoholic CP. Cerebrovascular disease (HR, 1.3; 95% CI, 1.2-1.4), chronic pulmonary disease (HR, 1.9; 95% CI, 1.8-2.1), ulcer disease (HR, 3.6; 95% CI, 3.3-3.9), diabetes (HR, 5.2; 95% CI, 5.0-5.6), and chronic renal disease (HR, 1.7; 95% CI, 1.5-1.9) occurred more frequently among patients with CP, but myocardial infarction did not (HR, 0.9; 95% CI, 0.8-1.0). Conclusions Based on a Danish nationwide cohort study, individuals with CP are at higher risk for death from cancer (particularly pancreatic cancer) and have a higher incidence of comorbidities than people without CP.

AB - Background & Aims We aimed to assess the risk of death, cancer, and comorbidities among patients with alcoholic and nonalcoholic chronic pancreatitis (CP). Methods We performed a nationwide retrospective cohort study, collecting data from Danish registries from 1995 through 2010. We evaluated the prevalences and incidences of death, cancers, and comorbidities among subjects with CP (cases) compared with age- and sex-matched individuals (controls). In total, 11,972 cases (71,814 person-years) and 119,720 controls (917,436 person-years) were included in the analysis. Hazard ratios (HR) were estimated by Cox proportional hazards regression. Results Forty-six percent of the cases died during the follow-up period, compared with 13.0% of controls (mean age, 63.7 vs 72.1 y; P <.0001), corresponding to a HR of 5.0 for CP (95% confidence interval [CI], 4.8-5.2). Cancer was a frequent cause of death among cases (10.2%) and controls (3.3%). Cancer (particularly pancreatic cancer) was a frequent cause of death among cases; the HR was 6.9 (95% CI, 7.5-11.8). Alcoholic CP did not produce a higher risk for cancer or death than nonalcoholic CP. Cerebrovascular disease (HR, 1.3; 95% CI, 1.2-1.4), chronic pulmonary disease (HR, 1.9; 95% CI, 1.8-2.1), ulcer disease (HR, 3.6; 95% CI, 3.3-3.9), diabetes (HR, 5.2; 95% CI, 5.0-5.6), and chronic renal disease (HR, 1.7; 95% CI, 1.5-1.9) occurred more frequently among patients with CP, but myocardial infarction did not (HR, 0.9; 95% CI, 0.8-1.0). Conclusions Based on a Danish nationwide cohort study, individuals with CP are at higher risk for death from cancer (particularly pancreatic cancer) and have a higher incidence of comorbidities than people without CP.

KW - Adult

KW - Aged

KW - Chi-Square Distribution

KW - Comorbidity

KW - Denmark

KW - Female

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Neoplasms

KW - Pancreatic Neoplasms

KW - Pancreatitis, Alcoholic

KW - Pancreatitis, Chronic

KW - Prevalence

KW - Prognosis

KW - Proportional Hazards Models

KW - Registries

KW - Retrospective Studies

KW - Risk Factors

KW - Time Factors

U2 - 10.1053/j.gastro.2013.12.033

DO - 10.1053/j.gastro.2013.12.033

M3 - Journal article

C2 - 24389306

SN - 0016-5085

VL - 146

SP - 989

EP - 994

JO - Gastroenterology

JF - Gastroenterology

IS - 4

ER -

Mortality, Cancer, and Comorbidities Associated With Chronic Pancreatitis: A Danish Nationwide Matched-Cohort Study

Abstract

Keywords

UN SDGs

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